1-(4-氟苯基)-3-(苯磺酰基)-1H-吡咯并[2,3-b]喹喔啉-2-胺 | 374922-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 中文名称: 1-(4-氟苯基)-3-(苯磺酰基)-1H-吡咯并[2,3-b]喹喔啉-2-胺
• 英文名称: 1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
• 英文别名: 3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine
• CAS: 374922-43-7
• 化学式: C₂₂H₁₅FN₄O₂S
• 分子量: 418.4
• InChiKey: CSFVFDHRYKBBPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Sirtuin modulators as inhibitors of cytomegalovirus
  申请人：The Trustees of Princeton University

  公开号：US10813934B2

  公开（公告）日：2020-10-27

  Agents and methods of inhibiting or improving the growth of viruses are provided.

  提供了抑制或改善病毒生长的制剂和方法。
• Use of SIRT1 Activators or Inhibitors to Modulate an Immune Response
  申请人：VERDIN ERIC M.

  公开号：US20100330114A1

  公开（公告）日：2010-12-30

  The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4 + T cells.
• Methods and Compositions for Modulating Tau Levels
  申请人：Gan Li

  公开号：US20120225864A1

  公开（公告）日：2012-09-06

  Methods and agents for reducing a level of an acetylated Tau polypeptide in a cell are provided. Methods for treating a tauopathy in an individual are also provided. Also provided is a method for diagnosing a cognitive impairment disorder in an individual. Methods for identifying an agent suitable for treating a tauopathy are also provided.
• Use of Sirt1 Activators or Inhibitors to Modulate an Immune Response
  申请人：THE J. DAVID GLADSTONE INSTITUTES

  公开号：US20140030295A1

  公开（公告）日：2014-01-30

  The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4 + T cells.
• METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS
  申请人：THE J. DAVID GLADSTONE INSTITUTES

  公开号：US20160015733A1

  公开（公告）日：2016-01-21

  Methods and agents for reducing a level of an acetylated Tau polypeptide in a cell are provided. Methods for treating a tauopathy in an individual are also provided. Also provided is a method for diagnosing a cognitive impairment disorder in an individual. Methods for identifying an agent suitable for treating a tauopathy are also provided.