Inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones. Controlled introduction of oxygenated aromatics: benzene, phenol, catechol, resorcinol, and pyrogallol annulation. Regiospecific total synthesis of sendaverine and a preparation of 6,7-benzomorphans
Inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones. Controlled introduction of oxygenated aromatics: benzene, phenol, catechol, resorcinol, and pyrogallol annulation. Regiospecific total synthesis of sendaverine and a preparation of 6,7-benzomorphans
A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula I, wherein R
1
and R
2
are substituents, and n, W, X and Y are defined within.
ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
申请人:Forma Therapeutics, Inc.
公开号:US20160229872A1
公开(公告)日:2016-08-11
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:
where R
1
, R
2
, R
3
, R
4
, R
5
, R
5′
, X
1
, X
2
, X
3
, n, and m are described herein.
A compound or its pharmaceutically acceptable salt, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula II, wherein the R group substituents, D, F, X, W and A are defined within.
本发明公开了一种化合物或其药学上可接受的盐、组合物和方法,可提供镇痛和减轻炎症。一种考虑使用的化合物具有与式 II 相对应的结构,其中 R 基取代基、D、F、X、W 和 A 在式 II 中定义。
Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
申请人:FORMA Therapeutics, Inc.
公开号:US10377773B2
公开(公告)日:2019-08-13
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:
where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.
本公开涉及可用于治疗癌症、神经退行性疾病、免疫性疾病、炎症性疾病、心血管疾病、缺血性疾病、病毒感染和疾病以及细菌感染和疾病的USP7抑制剂,其具有如下式子:
其中 R1、R2、R3、R4、R5、R5′、X1、X2、X3、n 和 m 在本文中描述。