1-(6-氟-3-吡啶基)-N-甲基甲胺 | 120740-03-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(6-氟-3-吡啶基)-N-甲基甲胺
• 英文名称: 1-(6-Fluoropyridin-3-yl)-N-methylmethanamine
• CAS: 120740-03-6
• 化学式: C₇H₉FN₂
• 分子量: 140.16
• InChiKey: FGIMOABAGJTCSV-UHFFFAOYSA-N

物化性质

• 沸点：
  213.4±25.0 °C(Predicted)
• 密度：
  1.090±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲胺 、 5-溴甲基-2-氟吡啶 在 乙酸乙酯 、 magnesium sulfate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以The procedure gave 1.35 g of the title compound as a crude orange-colored oil的产率得到1-(6-氟-3-吡啶基)-N-甲基甲胺
  参考文献：
  名称：

  .alpha.-unsaturated amines, their production and use

  摘要：

  本文描述了公式为：##STR1##的.alpha.-不饱和胺，其中X.sup.1和X.sup.2是这样的，其中一个是电子吸引基团，另一个是氢原子或电子吸引基团；R.sup.1是通过氮原子连接的基团；R.sup.2是氢原子或通过碳、氮或氧原子连接的基团；n是等于0、1或2的整数；A是杂环基团或环烃基团，以及它们的盐和它们作为杀虫和/或杀螨剂的农药用途。

  公开号：

  US06124297A1

文献信息

• Alpha-unsaturated amine pyridine compounds
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05175301A1

  公开（公告）日：1992-12-29

  .alpha.-Unsaturated amines of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R.sup.1 is a group attached through a nitrogen atom; R.sup.2 is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

  本文描述了化学式为：##STR1##的.alpha.-不饱和胺，其中X.sup.1和X.sup.2是电子吸引基团，其中一个是氢原子或电子吸引基团，R.sup.1是通过氮原子连接的基团，R.sup.2是氢原子或通过碳、氮或氧原子连接的基团，n是等于0、1或2的整数，A是杂环基团或环烃基团，以及它们的盐和它们作为杀虫和/或杀螨剂的农药用途。
• Halogen substituted 5-thiazole methane amine compounds
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05214152A1

  公开（公告）日：1993-05-25

  .alpha.-Unsaturated amines of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R.sup.1 is a group attached through a nitrogen atom; R.sup.2 is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

  本发明涉及一种以下式子的.alpha.-不饱和胺：##STR1## 其中X.sup.1和X.sup.2是这样的，其中一个是吸电子基团，另一个是氢原子或吸电子基团；R.sup.1是通过氮原子连接的基团；R.sup.2是氢原子或通过碳、氮或氧原子连接的基团；n是等于0、1或2的整数；A是杂环基团或环烃基团，以及它们的盐和作为杀虫和/或杀螨剂的农药用途。
• .alpha.-unsaturated amines, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05849768A1

  公开（公告）日：1998-12-15

  .alpha.-Unsaturated amines of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R.sup.1 is a group attached through a nitrogen atom; R.sup.2 is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

  本文描述了公式为：##STR1## 的.alpha.-不饱和胺，其中X.sup.1和X.sup.2是电子吸引基团和氢原子或电子吸引基团，R.sup.1是通过氮原子连接的基团，R.sup.2是氢原子或通过碳、氮或氧原子连接的基团，n是等于0、1或2的整数，A是杂环基团或环烃基团，以及它们的盐和作为杀虫剂和/或螨虫剂的农药应用。
• QUINAZOLINE DERIVATIVES
  申请人：Ple Patrick

  公开号：US20120165351A1

  公开（公告）日：2012-06-28

  The invention concerns quinazoline derivatives of Formula I or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X 1 , p, R 1 , q, R 2 , R 3 , R 4 , R 5 , Ring A, r and R 6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.

  该发明涉及公式I的喹唑啉衍生物，或其药学上可接受的盐、溶剂或前药，其中X1、p、R1、q、R2、R3、R4、R5、环A、r和R6中的每一个具有上述描述中定义的任何含义；其制备过程，含有它们的药物组合物以及它们在制造用于治疗细胞增殖性疾病或与血管生成和/或血管通透性相关的疾病状态的药物中的使用。
• Alpha-unsaturated amines, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0302389A2

  公开（公告）日：1989-02-08

  α-Unsaturated amines of the formula: wherein X¹ and X² are such that one is an electron-­attracting group with the other being a hydrogen atom or an electron-attracting group; R¹ is a group attached through a nitrogen atom; R² is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

  式中α-不饱和胺： 式中：X¹和X²一个是引电子基团，另一个是氢原子或引电子基团；R¹是通过氮原子连接的基团；R²是氢原子或通过碳原子、氮原子或氧原子连接的基团；n是等于0、1或2的整数；A是杂环基团或环烃基团；描述了其盐类及其作为杀虫剂和/或杀螨剂的农用化学品用途。