棕榈精 | 11140-06-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 棕榈精
• 中文别名: palmitintripalmitin三棕榈精甘油三棕榈酸酯软脂甘油三软脂酸酯
• 英文名称: Hexadecanoic acid, ester with 1,2,3-propanetriol
• 英文别名: hexadecanoic acid;propane-1,2,3-triol
• CAS: 11140-06-0
• 化学式: C19H40O5
• 分子量: 348.5
• InChiKey: CGBXSWXZXBQCMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.88
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] PHARMAACEUTICAL COMPOSITIONS COMPRISING FATTY ACID ESTERS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES ESTERS D'ACIDES GRAS
  申请人：ALKERMES PHARMA IRELAND LTD

  公开号：WO2013142198A1

  公开（公告）日：2013-09-26

  The present invention relates to an injectable, pharmaceutical composition comprising a C1-6 alkyl ester of a C10-20 fatty acid. In an embodiment, the fatty acid is ethyl oleate, isopropyl oleate, ethyl myristate, or isopropyl myristate. These compositions are useful for the delivery of anti-psychotic drugs.

  本发明涉及一种可注射的药物组合物，包括C10-20脂肪酸的C1-6烷基酯。在一种实施例中，脂肪酸为油酸乙酯、油酸异丙酯、肉豆蔻酸乙酯或肉豆蔻酸异丙酯。这些组合物适用于抗精神病药物的输送。
• [EN] PHARMACEUTICAL COMPOSITIONS COMPRISING BENZYL ALCOHOL<br/>[FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT DE L'ALCOOL BENZYLIQUE
  申请人：ALKERMES PHARMA IRELAND LTD

  公开号：WO2013142205A1

  公开（公告）日：2013-09-26

  The present invention relates to a pharmaceutical composition comprising benzyl alcohol and polyoxyethylene derivatives of sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.

  本发明涉及一种药物组合物，包括苯甲醇和羧酸山梨醇酯的聚氧乙烯衍生物，用于输送抗精神病药物。
• Nicotinic Acetylcholine Receptor Modulators
  申请人：Jiang Faming

  公开号：US20090118326A1

  公开（公告）日：2009-05-07

  The disclosure provides compounds capable of selectively or non-selectively modulating nicotinic acetylcholine receptors. The compounds, compositions, and methods described herein are useful, for example, in treating patients suffering from various medical conditions including pain, chemical addictions, Parkinson's disease, Alzheimer's disease, and neurodegenerative disorders. In one embodiment, the compounds comprise a 7- to 11-membered azabicyclo ring.

  该披露提供了能够选择性或非选择性调节尼古丁乙酰胆碱受体的化合物。这里描述的化合物、组合物和方法在治疗患有各种疾病的患者方面是有用的，包括疼痛、化学成瘾、帕金森病、阿尔茨海默病和神经退行性疾病。在一个实施例中，这些化合物包括一个由7到11个成员的氮杂双环环。
• [EN] NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS<br/>[FR] MODULATEURS DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：STANFORD RES INST INT

  公开号：WO2009058120A1

  公开（公告）日：2009-05-07

  The disclosure provides compounds capable of selectively or non-selectively modulating nicotinic acetylcholine receptors. The compounds, compositions, and methods described herein are useful, for example, in treating patients suffering from various medical conditions including pain, chemical addictions, Parkinson's disease, Alzheimer's disease, and neurodegenerative disorders. In one embodiment, the compounds comprise a 7- to 1 1 - membered azabicyclo ring.

  该披露提供了能够选择性或非选择性调节尼古丁乙酰胆碱受体的化合物。这里描述的化合物、组合物和方法在治疗患有各种疾病的患者中很有用，包括疼痛、化学成瘾、帕金森病、阿尔茨海默病和神经退行性疾病。在一个实施例中，这些化合物包括一个由7到11个成员的氮杂双环环。
• Fatty acid compounds, preparation and uses thereof
  申请人：——

  公开号：US20040192908A1

  公开（公告）日：2004-09-30

  The invention concerns novel molecules, their preparation and their uses, in particular in the field of human and veterinary medicine and cosmetics. The inventive compounds are partly fatty acid derivatives and exhibit advantageous pharmacological and cosmetic properties. The invention also concerns various uses of said compounds, the pharmaceutical compositions containing them and methods for preparing them. The inventive compounds are useful in particular for preventing and/or treating dyslipidemiae, cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, certain cancers, dermatological diseases and in cosmetics, for fighting against skin aging and its effects notably against wrinkles and the like

  这项发明涉及新颖分子，它们的制备和用途，特别是在人类和兽医医学以及化妆品领域。这些创新化合物部分是脂肪酸衍生物，并具有有利的药理和化妆品特性。该发明还涉及所述化合物的各种用途，含有它们的药物组合物以及制备它们的方法。这些创新化合物特别适用于预防和/或治疗血脂异常、心血管疾病、X综合征、再狭窄、糖尿病、肥胖、高血压、某些癌症、皮肤病以及在化妆品中，用于对抗皮肤衰老及其影响，尤其是对抗皱纹等。