棕榈酰高半胱氨酸 | 76822-97-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 棕榈酰高半胱氨酸
• 英文名称: Palmitoylhomocysteine
• 英文别名: (2S)-2-(hexadecanoylamino)-4-sulfanylbutanoic acid
• CAS: 76822-97-4
• 化学式: C₂₀H₃₉NO₃S
• 分子量: 373.6
• InChiKey: WPWJFABXGZAMQI-SFHVURJKSA-N

物化性质

• 沸点：
  550.6±45.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  67.4
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2930909090

文献信息

• Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
  申请人：——

  公开号：US20020106325A1

  公开（公告）日：2002-08-08

  The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrently detecting the vitronectin target imaging agent bound at the vitronectin receptor and the perfusion imaging agent; and c) forming an image from the detection of said vitronectin receptor targeted imaging agent and said perfusion imaging agent.

  本发明描述了一种在哺乳动物中进行并行成像的方法，包括： a) 向所述哺乳动物施用一个靶向维龙蛋白受体的成像剂和一个灌注成像剂；以及 b) 同时检测维龙蛋白靶向成像剂与维龙蛋白受体结合以及灌注成像剂；以及 c) 从检测到的维龙蛋白受体靶向成像剂和灌注成像剂形成图像。
• Liposome composition for delivery of nucleic acid
  申请人：Alza Corporation

  公开号：US20030031704A1

  公开（公告）日：2003-02-13

  A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delievery to a cell.

  描述了一种用于体内或体外递送核酸的脂质体组合物。组合物中的脂质体由（i）在生理pH下呈中性电荷，在低于生理pH值时呈正电荷的脂质和（ii）通过二硫苯基键连接到亲水聚合物的脂质组成。这些脂质体与核酸结合以递送到细胞。
• HETEROMULTIVALENT NANOPARTICLE COMPOSITIONS
  申请人：Case Western Reserve University

  公开号：US20140023591A1

  公开（公告）日：2014-01-23

  A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle having an outer surface and a plurality of targeting moieties conjugated to the surface of the nanoparticle, the targeting moieties includes a first activated platelet targeting moiety and a second activated platelet targeting moiety.

  用于诊断和治疗应用的组合物包括具有外表面的异多价纳米粒子，其表面上结合有多个靶向基团，这些靶向基团包括第一活化的血小板靶向基团和第二活化的血小板靶向基团。
• [EN] TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS<br/>[FR] AGONISTES DE TLR7/8 ET COMPOSITIONS LIPOSOMALES
  申请人：TORQUE THERAPEUTICS INC

  公开号：WO2020023680A1

  公开（公告）日：2020-01-30

  The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.

  本公开涉及一种利用远程加载的方法将调节剂（TLR）7/8激动剂装载到脂质体中，以及适用于通过该方法将TLR7/8激动剂装载到脂质体的部件套件。本公开进一步涉及包含TLR7/8激动剂盐的脂质体，并且利用该脂质体用于刺激免疫反应和/或治疗临床疾病。最后，本公开涉及一种适合远程装载到脂质体中的TLR7/8激动剂。
• Diagnostic Agents Selective Against Metalloproteases
  申请人：Bracco Imaging S.p.A

  公开号：EP2147684A1

  公开（公告）日：2010-01-27

  The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents.

  本发明涉及具有亲和力对金属蛋白酶MMP的芳基磺酰胺化合物，其化学式如下（I），其中R，R1，R2，R3，G和n在规范中有所说明，适当地标记有诊断成像或放射治疗成分。本发明还涉及它们的制备过程、包含它们的药物组成物以及它们作为诊断成像剂或放射治疗剂的用途。