1-[1,3-二甲基-4-(2-甲基乙基)-1H-吡唑并[3,4-b]吡啶-6-基]-4-(3,5-二氯-4-吡啶基)-氨基甲酰肼 | 547756-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 中文名称: 1-[1,3-二甲基-4-(2-甲基乙基)-1H-吡唑并[3,4-b]吡啶-6-基]-4-(3,5-二氯-4-吡啶基)-氨基甲酰肼
• 英文名称: 1-(3,5-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
• CAS: 547756-93-4
• 化学式: C₁₇H₁₉Cl₂N₇O
• 分子量: 408.3
• InChiKey: GDFXUTXWCNQTEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  96.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods and Compositions for Inhibiting Pathological Angiogenesis in the Eye
  申请人：Hla Timothy Tun

  公开号：US20090004207A1

  公开（公告）日：2009-01-01

  Disclosed herein are compositions and methods for inhibiting abnormal angiogenesis in the eye, particularly in the retina. The methods include administering to subject in need of treatment for pathological angiogenesis of the eye a pharmaceutically effective amount of an inhibitor of the receptor activity of the S1P2 receptor. Also included are compositions including an S1P2 receptor antagonist and an opthalmically acceptable excipient.
• Methods and Compositions for Inhibiting Atherosclerosis and Vascular Inflammation
  申请人：Hla Timothy Tun

  公开号：US20100068200A1

  公开（公告）日：2010-03-18

  Disclosed herein are compositions and methods for reducing inflammation associated with atherosclerosis and/or vascular inflammatory disease. The methods include administering to a subject in need of treatment for atherosclerosis and/or vascular inflammation a pharmaceutically effective amount of an inhibitor of the receptor activity of the S1P2 receptor. Also included are compositions including an S1P2 receptor antagonist and a pharmaceutically acceptable excipient.
• [EN] NHIBITOR OF THE RECEPTOR ACTIVITY OF THE S1P2 RECEPTOR FOR INHIBITING PATHOLOGICAL ANGIOGENESIS IN THE EYE<br/>[FR] INHIBITEUR DE L'ACTIVITÉ RÉCEPTEUR DU RÉCEPTEUR S1P1 PERMETTANT L'INHIBITION D'UNE ANGIOGENÈSE PATHOLOGIQUE DANS L'OEL
  申请人：UNIV CONNECTICUT

  公开号：WO2008154470A1

  公开（公告）日：2008-12-18

  [EN] Disclosed herein are compositions and methods for inhibiting abnormal angiogenesis in the eye, particularly in the retina. The methods include administering to subject in need of treatment for pathological angiogenesis of the eye a pharmaceutically effective amount of an inhibitor of the receptor activity of the S1P2 receptor. Also included are compositions including an S1P2 receptor antagonist and an opthalmically acceptable excipient.
  [FR] La présente invention concerne des compositions et des procédés d'inhibition d'une angiogenèse anormale dans l'oel, particulièrement dans la rétine. Les procédés comprennent l'administration au sujet en besoin de traitement pour une angiogenèse pathologique de l'oel d'une quantité efficace sur le plan pharmaceutique d'un inhibiteur de l'activité récepteur du récepteur S1P2. L'invention concerne également des compositions renfermant un antagoniste du récepteur S1P2 et un excipient acceptable sur le plan ophtalmique.
• [EN] METHODS AND COMPOSITIONS FOR INHIBITING ATHEROSCLEROSIS AND VASCULAR INFLAMMATION<br/>[FR] PROCÉDÉS ET COMPOSITIONS DESTINÉS À INHIBER L'ATHÉROSCLÉROSE ET UNE INFLAMMATION VASCULAIRE
  申请人：UNIV CONNECTICUT

  公开号：WO2010030976A2

  公开（公告）日：2010-03-18

  Disclosed herein are compositions and methods for reducing inflammation associated with atherosclerosis and/or vascular inflammatory disease. The methods include administering to a subject in need of treatment for atherosclerosis and/or vascular inflammation a pharmaceutically effective amount of an inhibitor of the receptor activity of the S1P2 receptor. Also included are compositions including an S1P2 receptor antagonist and a pharmaceutically acceptable excipient.