1-[3-(2-氨基乙基)-2-苯甲基-1H-吲哚-1-基]-1-戊酮 | 343263-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1-[3-(2-氨基乙基)-2-苯甲基-1H-吲哚-1-基]-1-戊酮
• 英文名称: N-[2-(2-benzyl-1H-indol-3-yl)ethyl]pentanamide
• CAS: 343263-95-6
• 化学式: C₂₂H₂₆N₂O
• 分子量: 334.5
• InChiKey: HDOIPCLEKCEANF-UHFFFAOYSA-N

物化性质

• 沸点：
  488.6±35.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• NOVEL LIGAND OF G PROTEIN COUPLED RECEPTOR PROTEIN AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1736775A1

  公开（公告）日：2006-12-27

  The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.

  本发明提供了一种筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，该G蛋白偶联受体蛋白包含与SEQ ID NO: 1所代表的氨基酸序列相同或基本相同的氨基酸序列，或其盐，其中包括使用受体蛋白或其盐和配体或其盐等；等等。本发明可用于筛选预防/治疗下列疾病的药物，例如白细胞减少症、白血病、淋巴瘤、恶性肿瘤、溃疡性结肠炎、类风湿性关节炎、肠道炎症性疾病、扁桃体疾病、胶原病、炎症性疾病、白细胞增多症、心力衰竭、遗传性肌肉疾病、肌肉萎缩症、神经肌肉变性疾病、心肌梗塞、肥胖症、糖尿病、高血脂症、动脉硬化、代谢综合征、血小板减少症、血小板减少症、癌症、肺水肿、多器官功能衰竭等。
• Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof
  申请人：Fujii Ryo

  公开号：US20080305110A1

  公开（公告）日：2008-12-11

  The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.
• US7927821B2
  申请人：——

  公开号：US7927821B2

  公开（公告）日：2011-04-19
• US8569481B2
  申请人：——

  公开号：US8569481B2

  公开（公告）日：2013-10-29