1-[二(4-氯苯基)甲氧基-(4-氯苯基)甲基]-4-氯苯 | 74562-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[二(4-氯苯基)甲氧基-(4-氯苯基)甲基]-4-氯苯
• 英文名称: bis-4,4'-dichlorobenzhydryl ether
• 英文别名: bis(4-chlorophenyl)methyl ether；bis-(4,4'-dichloro-benzhydryl)-ether；Bis-[bis-(4-chlor-phenyl)-methyl]-aether；Bis-(4,4'-dichlor-benzhydryl)-aether；1-[Bis(4-chlorophenyl)methoxy-(4-chlorophenyl)methyl]-4-chlorobenzene
• CAS: 74562-99-5
• 化学式: C₂₆H₁₈Cl₄O
• 分子量: 488.24
• InChiKey: GEGGALOUNJBBAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[二(4-氯苯基)甲氧基-(4-氯苯基)甲基]-4-氯苯 在 三氟甲磺酸 作用下， 以 氯仿 为溶剂， 反应 5.0h， 以38%的产率得到1,1’-亚甲基双(4-氯苯)
  参考文献：
  名称：

  ON the silylation of diarylcarbinols

  摘要：

  Because of their dismutation into benzophenones and diphenylmethanes, it is necessary to use chlorotrimethylsilane and not triflic acid as a catalyst for the silylation of diarylcarbinol with hexamethyldisilazane.

  DOI：

  10.1080/00397919608086745
• 作为产物：
  描述：

  4,4'-二氯二苯甲醇 在 2,2'-bipyridinium triflate 作用下， 以 二氯甲烷 为溶剂， 以93 %的产率得到1-[二(4-氯苯基)甲氧基-(4-氯苯基)甲基]-4-氯苯
  参考文献：
  名称：

  利用质子化的 2,2'-联吡啶盐作为有机反应中强大的布朗斯台德酸催化剂

  摘要：

  这是首次将现成的质子化2,2'-联吡啶盐用作布朗斯台德酸催化剂，加速一系列有机转化，包括芳香炔烃的水合、醇的醚化、脂肪醛的环三聚、里特反应、 Mannich 反应、Biginelli 反应、从醇制备取代烯烃、螺氧吲哚、双吲哚基甲烷和未环化四酮的合成，收率从好到高。这些结果有力地表明，质子化 2,2'-联吡啶催化体系的发展具有巨大的潜力。

  DOI：

  10.1021/acs.joc.2c02239

文献信息

• Deoxygenation of tertiary and secondary benzylic alcohols into alkanes with triethylsilane catalyzed by solid acid tin(IV) ion-exchanged montmorillonite
  作者：Michael Andreas Tandiary、Yoichi Masui、Makoto Onaka

  DOI：10.1016/j.tetlet.2014.05.042

  日期：2014.7

  We discovered an efficient protocol for the conversion of tertiary and secondary benzylic alcohols into the corresponding alkanes in good to quantitative yields by employing tin(IV) ion-exchanged montmorillonite (Sn-Mont) as a solid acid catalyst and Et3SiH as the hydride source. The reaction is likely to proceed via the SN1-type reaction mechanism, that is, the formation of carbenium ions, followed

  我们发现了一种有效的方案，可将锡（IV）离子交换的蒙脱石（Sn-Mont）作为固体酸催化剂，并将Et3SiH作为氢化物源，从而将叔和仲苄醇以良好的定量产率转化为相应的烷烃。该反应可能是经由S进行Ñ 1型反应机制，即，碳正离子的形成，随后加入来自硅烷氢化物。反应的后处理仅需要简单地过滤固体酸而不中和酸催化剂。
• CARBOXYLATION OF ALCOHOLS WITH CARBON MONOXIDE SUPERSATURATED IN STRONG ACID. FACILE SYNTHESIS OF 2,2-BIS(4-HALOPHENYL)ACETIC,-PROPIONIC, AND RELATED ACIDS
  作者：Yukio Takahashi、Norihiko Yoneda、Hiroshi Nagai

  DOI：10.1246/cl.1985.1733

  日期：1985.11.5

  Using 97% H2SO4 supersaturated with carbon monoxide, bis(4-halophenyl)methanols, 1,1-bis (4-halophenyl) ethanols and related alcohols were transformed to the carboxylic acids in 60–95% yields.

  使用 97% 一氧化碳过饱和的 H2SO4，双（4-卤代苯基）甲醇、1,1-双（4-卤代苯基）乙醇和相关醇以 60-95% 的产率转化为羧酸。
• An expedient, efficient and solvent-free synthesis of T3P®-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation
  作者：Srinivas Cheruku、Sandhya C. Nagarakere、Makanahalli P. Sunilkumar、Yatheesh Narayana、Kumara N. Manikyanally、Kanchugarakoppal S. Rangappa、Kempegowda Mantelingu

  DOI：10.1039/d1nj04502d

  日期：——

  An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P®) under microwave irradiation has been developed. The methodology has been deployed for a wide range of heterocycles and electron-withdrawing & electron-donating groups. The protocol resulted in good to excellent

  已经开发了一种方便、高效、经济、环境友好且无溶剂的苯甲醇与低活性氮亲核试剂的酰胺化方案，该方案在微波辐射下由丙基膦酸酐 (T3P®) 辅助。该方法已应用于广泛的杂环和吸电子和给电子基团。该协议在给定条件下产生了良好的产量（26 个示例，68-93% 的产量）。
• Pharmaceutical agents for the treatment of cerebral amyloidosis
  申请人：NYMOX CORPORATION

  公开号：EP1930308A1

  公开（公告）日：2008-06-11

  The invention relates to a compound of the following general formula (III): wherein: R1 and R2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and carboxyl; R3 is selected from the group consisting of amino, C1-C5 substituted amino and CH2; n and m are independently an integer of from 0-5; or a pharmaceutically acceptable salt of such compound; a compound of the following general formula (IV): wherein: R1 and R2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and ca rboxyl; R3 and R4 each are independent and selected from the group consisting of hydrogen and C1-C5 alkyl; n is an integer of from 1 to 5; or a pharmaceutically acceptable salt of such compound; a compound of the following general formula (V): wherein: R1 and R2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and carboxyl; R3 is selected from hydrogen and C1-C5 alkyl; R4 is selected from hydrogen and C1-C5 alkyl; n is an integer of from 1 to 5 inclusive; or a pharmaceutically acceptable salt of such compound; and a compound of the following general formula (VI): wherein: R1 and R2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and carboxyl; R3 and R4 each are independent and selected from hydrogen and C1-C5 alkyl; n is an integer of from 1 to 5 inclusive; or a pharmaceutically acceptable salt of such compound. Also compositions comprising the compounds III-VI as well as uses of said compounds.

  本发明涉及以下通式 (III) 的化合物： 其中 R1和R2各自为一个或多个独立取代基，选自由氢、C1-C5烷基、C2-C5烯基、C3-C5环烷基、C1-C5烷氧基、C2-C5炔基、卤素、C1-C5卤代烷基、烷基氨基、苯基、硝基和羧基组成的组； R3 选自氨基、C1-C5 取代的氨基和 CH2 组成的组； n 和 m 独立地为 0-5 之间的整数； 或此类化合物的药学上可接受的盐； 以下通式（IV）的化合物： 其中 R1和R2各自是一个或多个独立的取代基，选自由氢、C1-C5烷基、C2-C5烯基、C3-C5环烷基、C1-C5烷氧基、C2-C5炔基、卤素、C1-C5卤代烷基、烷基氨基、苯基、硝基和羧基组成的组； R3 和 R4 各自独立，选自由氢和 C1-C5 烷基组成的组； n 是 1 至 5 的整数； 或此类化合物的药学上可接受的盐； 以下通式(V)的化合物： 其中 R1和R2各自为一个或多个独立取代基，选自由氢、C1-C5烷基、C2-C5烯基、C3-C5环烷基、C1-C5烷氧基、C2-C5炔基、卤素、C1-C5卤代烷基、烷基氨基、苯基、硝基和羧基组成的组； R3 选自氢和 C1-C5 烷基； R4 选自氢和 C1-C5 烷基； n 是 1 至 5（包括 5）的整数； 或此类化合物的药学上可接受的盐；以及 以下通式(VI)的化合物： 其中 R1和R2各自是一个或多个独立的取代基，选自由氢、C1-C5烷基、C2-C5烯基、C3-C5环烷基、C1-C5烷氧基、C2-C5炔基、卤素、C1-C5卤代烷基、烷基氨基、苯基、硝基和羧基组成的组； R3 和 R4 各自独立，选自氢和 C1-C5 烷基； n 是 1 至 5（包括 5）的整数； 或此类化合物的药学上可接受的盐。 还包括由化合物 III-VI 组成的组合物以及所述化合物的用途。
• Transformation of carbinols by dichlorotris(triphenylphosphine)ruthenium and by some other transition-metal catalysts
  作者：Ilan Pri-Bar、Ouri Buchman、Hebert Schumann、Heinz J. Kroth、Jochanan Blum

  DOI：10.1021/jo01310a031

  日期：1980.10