1-丁氧基苯并三唑 | 60454-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 中文名称: 1-丁氧基苯并三唑
• 英文名称: 1-butoxy-1H-benzo[d]-1,2,3-triazole
• 英文别名: 1-butoxy-1H-benzotriazole；1-Butoxybenzotriazole
• CAS: 60454-99-1
• 化学式: C₁₀H₁₃N₃O
• 分子量: 191.233
• InChiKey: KRZGXODBKDWXNU-UHFFFAOYSA-N

物化性质

• 沸点：
  292.9±23.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正溴丁烷 、 1-羟基苯并三唑 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以67%的产率得到1-丁氧基苯并三唑
  参考文献：
  名称：

  Synthesis and Evaluation of 1-hydroxybenzotriazole Derivatives: Dual Inhibitors of Carbonic Anhydrase II and Sodium Hydrogen Exchanger I

  摘要：

  缺血再灌注损伤是器官移植中移植物功能受损的原因，也与脑功能障碍、缺血性心脏病、全身炎症反应综合征、胃肠功能障碍和多器官功能障碍综合征有关。细胞内pH对于缺血再灌注损伤中的细胞存活至关重要。钠氢交换蛋白I和碳酸酐酶II在调节细胞内pH方面起着关键作用。在再灌注期间抑制钠氢交换蛋白I和碳酸酐酶II分别被发现可以缓解缺血再灌注损伤。为了在缺血再灌注损伤治疗中获得更好的潜在药物分子，尝试合成钠氢交换蛋白和碳酸酐酶的双重抑制剂。羟基苯并三唑被认为是这种双重活性的中心药效团，合成了12种衍生物。所有衍生物均经过测试，用于检测钠氢交换蛋白I和碳酸酐酶II的抑制活性。对甲磺酸酯衍生物（12）发现是最有效的衍生物，对碳酸酐酶II的IC50为158.7±8.4 μM，对钠氢交换蛋白I的IC50为31.07±1.06 μM。尽管其效力低于标准药物，但这是对碳酸酐酶II和钠氢交换蛋白的双重抑制剂的首次报道。

  DOI：

  10.2174/1570178617999201014164710

文献信息

• Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives
  作者：Yu Sun、Qing-Hao Jin、Yan Han、Di Yu、Qiu-Ping Dai、Zhou-Jun Zheng

  DOI：10.2174/1570180813666160826113018

  日期：2017.1.26

  Background: 21 novel 1-alkoxy-1H-benzo[d]-1,2,3-triazole compounds were designed, prepared and evaluated for their antidepressant and anticonvulsant effects in mice. Method: Compound 19 significantly decreased immobility time in the FST without altering the locomotor activity in the open field test, and exhibited higher levels of efficacy than the reference standard fluoxetine. Compound 19 significantly increased 5-HT, NE and 5-HIAA levels in mice brain, implying that the antidepressant activity might be mediated by these neurotransmitters. In the seizure test, compound 19 also showed better anticonvulsant activity against MES, whereas had not shown neurotoxicity (300 mg/kg). Conclusion: Our data indicated that compound 19 could potentially be used as the antidepressant drug in patients with epilepsy.

  背景：设计、制备并评估了21种新型1-烷氧基-1H-苯并[d]-1,2,3-噻唑化合物在小鼠中的抗抑郁和抗惊厥效果。 方法：化合物19在强迫游泳试验（FST）中显著减少了动物的失动时间，而不改变开放场实验中的运动活动，其疗效高于参照标准药物氟西汀。化合物19显著提高了小鼠大脑中5-HT、NE和5-HIAA的水平，这表明其抗抑郁活性可能与这些神经递质有关。在癫痫测试中，化合物19在对抗MES方面也表现出更好的抗惊厥活性，同时没有显示出神经毒性（300 mg/kg）。 结论：我们的数据表明，化合物19可能作为抗抑郁药用于癫痫患者。
• Novel copper and copper alloy corrosion inhibitors
  申请人：CALGON CORPORATION

  公开号：EP0397450A1

  公开（公告）日：1990-11-14

  The use of alkoxybenzotriazoles to inhibit the corrosion of metallic surfaces in contact with an aqueous system. Systems and compositions containing alkoxybenzotriazole are also claimed.

  使用烷氧基苯并三唑抑制与水体系接触的金属表面的腐蚀。还要求含有烷氧基苯并三唑的体系和组合物。
• ROTATION TRANSMISSION APPARATUS WITH BUILT-IN ONE-WAY CLUTCH
  申请人：NSK LTD.

  公开号：EP1770309A1

  公开（公告）日：2007-04-04

  In order to provide a one-way clutch-containing rotation transmission apparatus of a high performance and an excellent durability, which shows a satisfactory lubricating property in a one-way clutch and a rolling bearing over a wide temperature range from a low temperature to a high temperature, in which an antirust agent for preventing a corrosion by rainwater or the like has little environmental burden and which does not cause an exfoliation of metal materials under a vibrating condition, a grease composition, employing a synthetic oil as a base oil, also employing at least either of an urea compound and a metal soap as a thickener and containing a non-barium type antirust agent in an amount of from 1.0 to 10 mass % with respect to the entire amount of the grease, is sealed in the rolling bearing and the one-way clutch.

  为了提供一种单向离合器式旋转传动装置，它具有高性能和出色的耐久性，在从低温到高温的宽温度范围内，在单向离合器和滚动轴承中显示出令人满意的润滑性能、一种润滑脂组合物，采用合成油作为基础油，还至少采用尿素化合物和金属皂中的一种作为增稠剂，并含有非钡型防锈剂，其用量为 1.0 至 10 质量％的非钡型防锈剂，密封在滚动轴承和单向离合器中。
• GREASE COMPOSITION FOR HUB UNIT BEARING, AND HUB UNIT BEARING FOR VEHICLES
  申请人：NSK LTD.

  公开号：EP1847586A1

  公开（公告）日：2007-10-24

  An object of the invention is to provide a grease composition capable of keeping a good lubrication condition for a long period of time even when water has mixed therein, thereby inhibiting white structure flaking and corrosion. Another object is to provide a vehicular hub unit bearing which hardly suffers from white structure flaking and corrosion even when used in an environment where water may penetrate into it and which therefore has a long life. The invention provides a rolling bearing with, sealed up therein, a grease composition containing a waterproof film-forming additive added thereto; a grease composition for hub unit bearings, containing a base oil that comprises at least one of mineral oil and synthetic oil as the main ingredient thereof, and a thickener and a flaking inhibitor; and a vehicular hub unit bearing with the grease composition sealed up therein.

  本发明的一个目的是提供一种润滑脂组合物，即使其中混有水，也能长时间保持良好的润滑状态，从而抑制白色结构剥落和腐蚀。另一个目的是提供一种车辆轮毂单元轴承，即使在可能渗水的环境中使用，该轴承也几乎不会出现白色结构剥落和腐蚀，因此具有较长的使用寿命。 本发明提供了一种滚动轴承，其中密封有一种含防水成膜添加剂的润滑脂组合物；一种用于轮毂单元轴承的润滑脂组合物，其中含有一种基础油，其主要成分至少包括矿物油和合成油中的一种，以及一种稠化剂和一种剥落抑制剂；以及一种密封有该润滑脂组合物的车辆轮毂单元轴承。
• RESIN LUBRICATION GREASE COMPOSITION
  申请人：Kyodo Yushi Co., Ltd.

  公开号：EP4098725A1

  公开（公告）日：2022-12-07

  The present invention provides a grease composition to be used for lubrication between resin-made members or lubrication between a resin-made member and a member made from another material. With respect to the total mass of the composition, more than 0.5 mass % but less than 7.5 mass% of a solid organic molybdenum compound is contained.

  本发明提供了一种润滑脂组合物，可用于树脂制构件之间的润滑或树脂制构件与其他材料制构件之间的润滑。就组合物的总质量而言，固体有机钼化合物的含量大于 0.5%，但小于 7.5%。