氟乙酰溴苯胺 | 351-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟乙酰溴苯胺
• 英文名称: fluoro-acetic acid-(4-bromo-anilide)
• 英文别名: Fluor-essigsaeure-(4-brom-anilid)；N-(4-Bromophenyl)-2-fluoroacetamide
• CAS: 351-05-3
• 化学式: C₈H₇BrFNO
• 分子量: 232.052
• InChiKey: ACCDBHBOYZJSDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氟乙酰胺 、 4-溴苯胺 生成 氟乙酰溴苯胺
  参考文献：
  名称：

  Kitano et al., Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1955, vol. 58, p. 54,55

  摘要：

  DOI：

文献信息

• Studies on organic fluorine compounds. VIII.—N-Substituted fluoroacetamides as insecticides and rodenticides
  作者：Ernst D. Bergmann、P. Moses、M. Neeman

  DOI：10.1002/jsfa.2740080706

  日期：1957.7

  N-Mono- and NN-disubstituted fluoracetamides have been tested as potential larvicides, contact insecticides and rodenticides. All monosubstituted amides were toxic to larvae of Musca vicina Macq. at a concentration of 100 p.p.m. Disubstituted amides were inactive or only slightly active. Only the amides monosubstituted by relatively small aryl radicals (phenyl, p-tolyl, p-fluorophenyl and p-chlorophenyl)

  N-单取代和 NN-二取代氟乙酰胺已被测试为潜在的杀幼虫剂、接触杀虫剂和杀鼠剂。所有单取代酰胺对 Musca vicina Macq 的幼虫都有毒性。在 100 ppm 的浓度下，双取代酰胺没有活性或只有轻微活性。只有被相对较小的芳基（苯基、对甲苯基、对氟苯基和对氯苯基）单取代的酰胺对成年麝香鼠表现出接触毒性。一种对 DDT 具有高度抗性的菌株。所有化合物对实验室大鼠都是有毒的。具有小芳基的 N-单芳基酰胺的近似 LD50 值最低（4 至 8 毫克/千克）。具有较大芳基取代基（α-和β-萘基、对二苯基和对溴苯基）的那些具有稍高的 LD50 值。N-芳基酰胺的摩尔 LD50 值落在一个狭窄的范围内。
• SYNTHETIC METHODS AND COMPOSITIONS
  申请人：Jimenez Leslie S.

  公开号：US20100331566A1

  公开（公告）日：2010-12-30

  The invention provides synthetic methods that utilize bromo or chloro substituents as blocking groups during the functionalization of aromatic rings, as well as compounds that are prepared from such methods.

  这项发明提供了一种利用溴或氯取代基作为阻塞基团的合成方法，用于在芳香环官能化过程中，以及从这些方法中制备的化合物。
• Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
  申请人：Buchwald L. Stephen

  公开号：US20050250959A1

  公开（公告）日：2005-11-10

  One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond between the sulfur atom of a thiol moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper(II)-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-carbon bond between the carbon atom of cyanide ion and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In another embodiment, the present invention relates to a copper-catalyzed method of transforming an aryl, heteroaryl, or vinyl chloride or bromide into the corresponding aryl, heteroaryl, or vinyl iodide. Yet another embodiment of the present invention relates to a tandem method, which may be practiced in a single reaction vessel, wherein the first step of the method involves the copper-catalyzed formation of an aryl, heteroaryl, or vinyl iodide from the corresponding aryl, heteroaryl, or vinyl chloride or bromide; and the second step of the method involves the copper-catalyzed formation of an aryl, heteroaryl, or vinyl nitrile, amide or sulfide from the aryl, heteroaryl, or vinyl iodide formed in the first step.

  本发明的一个方面涉及铜催化的碳-杂原子和碳-碳键形成方法。在某些实施例中，本发明涉及铜催化的方法，用于在芳基、杂芳基或乙烯卤代物或磺酸盐的活性碳和巯基官能团的硫原子之间形成碳-硫键。在其他实施例中，本发明涉及铜（II）催化的方法，用于在芳基、杂芳基或乙烯卤代物或磺酸盐的活性碳和酰胺的氮原子之间形成碳-氮键。在某些实施例中，本发明涉及铜催化的方法，用于在氰离子的碳原子和芳基、杂芳基或乙烯卤代物或磺酸盐的活性碳之间形成碳-碳键。在另一实施例中，本发明涉及一种铜催化的方法，将芳基、杂芳基或乙烯氯化物或溴化物转化为相应的芳基、杂芳基或乙烯碘化物。本发明的另一实施例涉及串联方法，可以在单个反应容器中实施，其中该方法的第一步涉及从相应的芳基、杂芳基或乙烯氯化物或溴化物中铜催化形成芳基、杂芳基或乙烯碘化物；该方法的第二步涉及从第一步形成的芳基、杂芳基或乙烯碘化物中铜催化形成芳基、杂芳基或乙烯腈、酰胺或硫化物。
• Hydroboronation process
  申请人：Commonwealth Scientific

  公开号：US20040133028A1

  公开（公告）日：2004-07-08

  The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

  本发明涉及合成芳基或烯基硼酸酯的方法，包括在第8-11族金属催化剂的存在下，通过反应以下化合物之一：(i) 具有烯丙基取代位上卤素或类卤素取代基的烯烃化合物；或(ii) 具有环取代位上卤素或类卤素取代基的芳香环，与双取代单氢硼烷。本发明还涉及在偶联反应中使用这些硼酸酯。本发明还涉及某些双取代单氢硼烷和芳基或烯基硼酸酯。
• Pesticidal compositions
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0347227A1

  公开（公告）日：1989-12-20

  A palatable pesticidal composition in solid form comprising, based on the total composition, (a) 0.5 to 33 weight % of ethylene/vinyl acetate copolymer with from 18 to 50 weight % vinyl acetate, (b) an effective amount of a bioactive agent, and (c) a protein/carbohydrate/lipid source providing the remaining weight.

  一种固体形式的适口杀虫组合物，以组合物总量为基准，包括 (a) 0.5 至 33 重量百分比的乙烯/醋酸乙烯共聚物，其中醋酸乙烯占 18 至 50 重量百分比、 (b) 有效量的生物活性剂，以及 (c) 提供剩余重量的蛋白质/碳水化合物/脂质来源。