1-乙酰基-2,5-二氢-1H-吡咯-2-羧酸 | 76945-40-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-乙酰基-2,5-二氢-1H-吡咯-2-羧酸
• 英文名称: 1-Acetyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid
• 英文别名: 1-acetyl-2,5-dihydropyrrole-2-carboxylic acid
• CAS: 76945-40-9
• 化学式: C₇H₉NO₃
• mdl: MFCD18810215
• 分子量: 155.15
• InChiKey: VBHKUSGNBBQVID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER
  申请人：MERCK & CO., INC.

  公开号：EP0942754B1

  公开（公告）日：2003-05-07
• METHOD FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS
  申请人：Georg-August-Universität Göttingen Stiftung des Öffentlichen Rechts (Bereich Humanmedizin)

  公开号：EP1909814A1

  公开（公告）日：2008-04-16
• Peptides for induction and enhancement of apoptosis in tumor cells
  申请人：Georg-August-Universität Göttingen Stiftung öffentlichen Rechts (ohne Bereich Humanmedizin)

  公开号：EP1909814B1

  公开（公告）日：2015-06-24
• Method For Induction and Enhancement of Apoptosis In Tumor Cells
  申请人：Grundker Carsten

  公开号：US20080167250A1

  公开（公告）日：2008-07-10

  The present invention relates to methods for inducing and enhancing apoptosis in pathogenic cells. In particular, the present invention relates to the use of GnRH II antagonists for inducing and enhancing apoptosis of specific types of tumor cells, i.e. breast cancer and malignant melanoma as well as gynaecological cancers like endometrial or ovarian cancer, expressing the GnRH II receptor as well as to methods relating thereto. In addition, new GnRH II antagonists are provided.
• PHARMACEUTICAL COMPOSITIONS AND METHODS FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS
  申请人：GRUENDKER CARSTEN

  公开号：US20120004182A1

  公开（公告）日：2012-01-05

  The present invention relates to methods for inducing and/or enhancing apoptosis in pathogenic cells. In particular, the present invention relates to the use of GnRH II antagonists in combination with at least one further compound selected from the group of selective estrogen receptor modulators (SERM), Aromatase inhibitors, and glycolysis inhibitors or salts or solvates thereof for inducing and/or enhancing apoptosis of specific types of tumor cells, expressing the GnRH II receptor as well as to methods relating thereto.