氟沙仑 | 4776-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟沙仑
• 中文别名: 氟洛克生；氟沙仑氟溴柳胺氟洛克生；氟洒兰；氟溴柳胺
• 英文名称: 3,5-dibromo-3'-trifluoromethylsalicylanilide
• 英文别名: Caswell No. 290；fluorosalan；3,5-dibromo-2-hydroxy-N-(3-trifluoromethyl-phenyl)-benzamide；3,5-dibromo-2-hydroxy-N-(3-trifluoromethyl-phenyl)benzamide；3,5-dibromo-3'-trifluoromethyl salicylanilide；3,5-dibromo-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide
• CAS: 4776-06-1
• 化学式: C₁₄H₈Br₂F₃NO₂
• 分子量: 439.026
• InChiKey: VYKKDKFTDMVOBU-UHFFFAOYSA-N

物化性质

• 沸点：
  371.4±42.0 °C(Predicted)
• 密度：
  1.887±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• LogP：
  6.970 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氟沙仑 、 丁炔二酸二甲酯 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 6,8-dibromo-2-methoxycarbonylmethyl-4-oxo-3-(3-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  一类新的1,3-苯并恶嗪酮类化合物作为潜在的中枢神经系统制剂。

  摘要：

  DOI：

  10.1021/jm00299a047
• 作为产物：
  描述：

  3,5-二溴-2-羟基苯甲酸 在 三氯化磷 作用下， 以 氯苯 为溶剂， 反应 3.25h， 生成 氟沙仑
  参考文献：
  名称：

  Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus

  摘要：

  A series of 55 salicylamides, including 3,5-dibromo-, 5-n-alkyl-, and 5-n-acylsalicyloyl derivatives of various anilines, heterocyclic amines, benzylamines, and alkylamines, was synthesized and evaluated for in vitro antibacterial activity against Actinomyces viscosus, an adherent oral microorganism implicated in periodontal disease. The in vitro minimum inhibitory concentrations of 15 4'-bromosalicylanilides were found to correlate (r = 0.92) with estimated log D values. Several nonhalogenated salicylanilides, such as 5-n-hexyl- (40) and 5-n-decanoyl-4'-nitrosalicylanilide (47), were found to exhibit higher levels of in vitro antibacterial activity against a number of Actinomycetes than did tribromsalan (1) or fluorophene (2).

  DOI：

  10.1021/jm00142a023

文献信息

• [EN] CARBONATE PRODRUGS AND METHODS OF USING THE SAME<br/>[FR] PROMÉDICAMENTS CARBONATÉS ET LEURS MÉTHODES D'UTILISATION
  申请人：NEUROGESX INC

  公开号：WO2009143297A1

  公开（公告）日：2009-11-26

  The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.

  本发明提供了碳酸盐前药，其包括连接到母药基团的羟基或羧基上的碳酸磷酸酐前药基团。这些前药可能比母药具有改进的物理化学性质。还提供了使用碳酸盐前药治疗对母药具有响应的疾病或症状的方法，以及配套工具和单剂量。
• Organometallic Complex, Luminescent Solid, Organic el Element and Organic el Display
  申请人：Sotoyama Wataru

  公开号：US20070224447A1

  公开（公告）日：2007-09-27

  The present invention aims to provide organic EL elements etc., containing phosphorescent organometallic complexes, that can exhibit longer durability, higher emitting efficiency, superior thermal/electrical stability, significantly longer operating life. The organic EL elements comprise an organic thin layer interposed between a positive hole transport layer and a electron transport layer, the organic thin layer comprises an organometallic complex comprising at least a metal element, a tridentate ligand, and a monodentate ligand, wherein the tridentate ligand bonds with the metal atom through two nitrogen atoms and one carbon atom, and the carbon atom exists between the two nitrogen atoms, and a monodentate ligand bonds with the metal atom through a atom selected from the group consisting of C, N, O, P and S atoms.

  本发明旨在提供含有磷光有机金属配合物的有机EL元件等，其能够展现更长的耐久性、更高的发光效率、优越的热/电稳定性以及显著更长的使用寿命。有机EL元件包括位于正空穴传输层和电子传输层之间的有机薄层，该有机薄层包括至少一种金属元素、一个三齿配体和一个单齿配体的有机金属配合物，其中三齿配体通过两个氮原子和一个碳原子与金属原子结合，碳原子存在于两个氮原子之间，而单齿配体通过来自由C、N、O、P和S原子组成的原子与金属原子结合。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• METHOD AND APPARATUS FOR PREPARING A SOLUTION OF A SHEAR SENSITIVE MATERIAL
  申请人：Hathaway, JR. Royal D.

  公开号：US20090287021A1

  公开（公告）日：2009-11-19

  The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.

  本发明提供了一种新型的装置和方法，用于制备剪切敏感材料的溶液。
• ACTIVE DELIVERY SYSTEMS FORMULATIONS
  申请人：HOMOLA Andrew M.

  公开号：US20100040565A1

  公开（公告）日：2010-02-18

  The present invention relates to active delivery system formulations, and methods of making and using the same. Said formulations, when applied to a substrate surface, form a protective coating on the surface and permit constituent active agents to act on the surface and in the surrounding medium.

  本发明涉及活性传递系统配方，以及制备和使用这些配方的方法。当这些配方应用到基底表面时，在表面形成一层保护性涂层，并允许组分活性剂在表面和周围介质中起作用。