1-烯丙氧基-2-(丙-1-烯基)苯 | 111801-75-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-烯丙氧基-2-(丙-1-烯基)苯
• 英文名称: 1-allyloxy-2-(prop-1-enyl)benzene
• 英文别名: 1-(allyloxy)-2-(prop-1-en-1-yl)benzene；allyl-(2-propenyl-phenyl)-ether；Allyl-(2-propenyl-phenyl)-aether；2-Allyloxy-1-propenylbenzene；1-prop-2-enoxy-2-prop-1-enylbenzene
• CAS: 111801-75-3
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: IRXHERIODKLDRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  266.4±9.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-烯丙氧基-2-(丙-1-烯基)苯 在 Grubbs catalyst first generation 作用下， 以 氘代氯仿 为溶剂， 生成 2H-色烯
  参考文献：
  名称：

  顺序异构化和闭环易位：用于苯并稠合杂环的合成的被掩盖的苯乙烯基和乙烯基氧基芳基

  摘要：

  通过使用钌介导的异构化和钌的合成，证明了将芳基烯丙基醚和芳基烯丙基用作掩蔽的乙烯基醚和1-丙烯基苯基用于闭环复分解（RCM），导致合成苯并稠合的杂环。介导的RCM反应。这导致了多种产物的合成，包括两种取代的苯并[1,4]二恶英，萘并[2,3- b ] [1,4]二恶英，2 H-色烯和苯并[ b ]呋喃。

  DOI：

  10.1016/s0040-4039(03)01545-4
• 作为产物：
  描述：

  2-烯丙基酚 在 [RuHCl(CO)(PPh₃)₃] potassium carbonate 作用下， 以 丙酮 、 甲苯 为溶剂， 反应 24.0h， 生成 1-烯丙氧基-2-(丙-1-烯基)苯
  参考文献：
  名称：

  Ring-closing metathesis for the synthesis of 2H- and 4H-chromenes

  摘要：

  Six 4H-chromenes were synthesized from substituted phenols using vinylstannylation and ring-closing metathesis (RCM) as key steps. In addition, a different approach involving amongst other steps, an aryl allyl isomerization and RCM afforded a set of seven 2H-chromenes from phenolic precursors. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.020

文献信息

• Anti-Markovnikov Hydroazidation of Activated Olefins via Organic Photoredox Catalysis
  作者：Nicholas P. R. Onuska、Megan E. Schutzbach-Horton、José L. Rosario Collazo、David. A. Nicewicz

  DOI：10.1055/s-0039-1690691

  日期：2020.1

  bioactive and medicinally relevant molecules. Historically, the formal hydroazidation of simple activated olefins and styrenes has proven difficult due to the inherent propensity of these compounds to oligomerize. Herein is disclosed a method for the anti-Markovnikov hydroazidation of activated olefins, catalyzed by an organic acridinium salt under irradiation from blue LEDs. This method is applicable

  有机叠氮化物可作为伯胺的合成有用替代物，伯胺是生物活性和医学相关分子中普遍存在的官能团。从历史上看，由于这些化合物固有的低聚倾向，简单的活化烯烃和苯乙烯的正式氢化叠氮化已被证明是困难的。本文公开了一种在蓝色LED的照射下由有机吖啶鎓盐催化的活化烯烃的反马尔可夫尼科夫氢化叠氮化的方法。该方法适用于各种取代苯乙烯和末端苯乙烯以及几种乙烯基醚，以中等至优异的产率产生合成通用的氢化叠氮化产物。
• Highly efficient nitrogen chelated ruthenium carbene metathesis catalysts
  作者：Yulian Duan、Tao Wang、Qingxiao Xie、Xiaobo Yu、Weijie Guo、Jianhui Wang、Guiyan Liu

  DOI：10.1039/c6dt03899a

  日期：——

  metathesis catalysts containing an N-heterocyclic carbene (NHC) and a carbonyl group have been developed and their catalytic activities for olefin metathesis reactions were investigated. The X-ray structure of the [(H2IMes)(Cl)2Ru]C(H)CH2[p-F(C6H3)NC(CF3)(C(O)OCH2CH3)] complex shows that the carbonyl oxygen of the ester and the imine nitrogen are both coordinated to the Ru metal to give an octahedral

  已开发出一系列含有N-杂环卡宾（NHC）和羰基的氮螯合钌卡宾复分解催化剂，并研究了它们对烯烃复分解反应的催化活性。[（H 2 IMes）（Cl）2 Ru] C（H）CH 2 [ p -F（C 6 H 3）NC（CF 3）（C（O）OCH 2 CH 3）]配合物表明，酯的羰基氧和亚胺氮都与Ru金属配位，得到八面体结构。测试了这些钌卡宾配合物对烯烃复分解反应的催化活性。一些带有吸电子基团的配合物具有较高的引发速率。这些复合物对于闭环复分解和交叉复分解均显示出优异的性能。
• Alkene cleavage by white-rot Trametes hirsuta: Inducing enzyme activity by a fungicide
  作者：Aashrita Rajagopalan、Birgit Seisser、Francesco G. Mutti、Markus Schober、Wolfgang Kroutil

  DOI：10.1016/j.molcatb.2013.02.002

  日期：2013.6

  Alkene cleavage is a widely employed oxidation reaction in organic chemistry. An enzyme preparation of the wood degrading fungus Trametes hirsuta is known to cleave the CC double bond adjacent to an aromatic ring to give the corresponding carbonyl compound at the expense of molecular oxygen as the sole oxidant. Lab-grown fungus cultures displayed varied activity and lost their alkene cleavage activity

  烯烃裂解是有机化学中广泛使用的氧化反应。已知木材降解真菌Trametes hirsuta的酶制剂会切割与芳环相邻的CC双键，以相应的羰基化合物为代价，而以分子氧作为唯一的氧化剂。实验室生长的真菌培养物表现出不同的活性，并且随着世代的生长而失去了其对烯烃的裂解活性。t-茴香脑是酶最广泛接受的底物，被描述为某些具有强大杀真菌特性的植物生产的香精油的主要成分。现在我们可以证明，加入杀菌剂t可以提高烯烃的裂解活性。-在培养生长过程中的茴香脑是代表生产具有一致水平的高烯烃裂解活性的细胞的有效方法。
• Thiol/ene compositions
  申请人：Loctite (Ireland) Ltd.

  公开号：US05021512A1

  公开（公告）日：1991-06-04

  Curable thiol/ene compositions comprise: (1) a multifunctional styryloxy monomer having one or more of the following structures ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are selected from vinyl (--CH.dbd.CH.sub.2), 1-propenyl (--CH.dbd.CH--CH.sub.3), isopropenyl ##STR2## hydrogen, lower alkyl or alkoxy, provided that at least one of R.sup.1, R.sup.2 and R.sup.3 must be vinyl, 1-propenyl or isopropenyl; n is an integer .gtoreq.1; if n=1, then R.sup.4 is a monovalent hydrocarbon radical containing one free-radically copolymerizable alkenyl or cycloalkenyl group, if n.gtoreq.2, R.sup.4 is a multivalent hydrocarbon radical which may contain a maximum of one free-radically copolymerizable alkenyl or cycloalkenyl group; R.sup.5 is a divalent hydrocarbon radical; or a carbon atom which is part of a cyclic group in the radical G; or a radical of formula ##STR3## where R.sup.7 is a divalent hydrocarbon radical; if n=1, G is a monovalent organic or inorganic radical, free of phenolic hydroxyl groups or other groups which substantially interfere with radical polymerization, containing one free-radically copolymerizable alkenyl or cycloalkenyl group; if n.gtoreq.2, G is a multivalent organic or inorganic radical, free of phenolic hydroxyl groups or other groups which substantially interfere with radical polymerization, which may contain a maximum of one free-radically copolymerizable alkenyl or cycloalkenyl group; R.sup.6 is a lower alkyl or cycloalkyl group; or if n=1, R.sup.6 may also be an alkenyl or cycloalkenyl group, provided that G does not contain an alkenyl or cycloalkenyl group. (2) a multifunction thiol. (3) a free-radical curing rate accelerator. Novel styryloxy compounds are described which are reaction products of isoeugenol and (a) multifunctional epoxy compounds or (b) allyl glycidyl ether with or without a multifunctional polydimethylsiloxane.

  可治愈的硫醇/烯组合物包括：(1)一种多功能的苯乙烯氧单体，具有以下一种或多种结构之一：其中R1、R2和R3从乙烯（--CH.dbd.CH.sub.2）、1-丙烯基（--CH.dbd.CH--CH.sub.3）、异丙烯基##STR2##氢、低级烷基或烷氧基中选择，但必须至少有R1、R2和R3中的一个是乙烯、1-丙烯基或异丙烯基；n是大于等于1的整数；如果n=1，则R4是含有一个自由基共聚烯基或环烯基基团的单价碳氢基团，如果n≥2，则R4是一个多价碳氢基团，最多可以含有一个自由基共聚烯基或环烯基基团；R5是一个二价碳氢基团；或者是G基团中的一个环状基团中的碳原子；或式子##STR3##其中R7是一个二价碳氢基团；如果n=1，则G是一个单价的有机或无机基团，不含酚羟基或其他实质上干扰自由基聚合的基团，含有一个自由基共聚烯基或环烯基基团；如果n≥2，则G是一个多价的有机或无机基团，不含酚羟基或其他实质上干扰自由基聚合的基团，最多可以含有一个自由基共聚烯基或环烯基基团；R6是一个低级烷基或环烷基基团；或者如果n=1，则R6也可以是烯基或环烯基基团，但G不含有烯基或环烯基基团。(2)一种多功能硫醇。(3)一种自由基固化速率促进剂。还描述了新的苯乙烯氧化合物，它们是异丁香酚和(a)多功能环氧化合物或(b)丙烯酸甘油醚与或不带多功能聚二甲基硅氧烷的反应产物。
• Particulate air pollution and hospital admissions in Christchurch, New Zealand
  作者：J.A. McGowan、P.N. Hider、E. Chacko、G.I. Town

  DOI：10.1111/j.1467-842x.2002.tb00266.x

  日期：2002.2

  Aims: Winter air pollution in Christchurch is dominated by particulate matter from solid fuel domestic heating. The aim of the study was to explore the relationship between particulate air pollution and admissions to hospital with cardio-respiratory illnesses.Methods: Particulate air pollution statistics (PM10) were obtained from the Canterbury Regional Council monitoring station in the city. The New Zealand Health Information Service provided data on admissions to the Princess Margaret and Christchurch Hospitals for the period June 1988 through December 1998 for both adults and children with cardiac and respiratory disorders. The relationship between PM10 and admissions was explored using a time series analysis approach controlling for weather variables. Missing values were interpolated from carbon monoxide data for the same time period, as carbon monoxide and PM10 were highly correlated.Results: There was a significant association between PM10 levels and cardio-respiratory admissions. For all age groups combined there was a 3.37% increase in respiratory admissions for each interquartile rise in PM10 (interquartile value 14.8 mcg/m(3)). There was also a 1.26% rise in cardiac admissions for each interquartile rise in PM10. There was no relationship between PM10 and admissions for appendicitis, the control condition selected.Conclusions: In keeping with overseas studies, there is evidence in Christchurch of a relationship between ambient particulate levels and admissions with cardiac and respiratory illnesses. The size of the effect is consistent with overseas data, with the greatest impact for respiratory disorders.Implications: These results indicate that measures to control ambient particulate levels have the potential to reduce hospital admissions for cardio-respiratory illnesses.