1-甲基-2-哌啶甲酰肼 | 89856-16-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-甲基-2-哌啶甲酰肼
• 中文别名: N-[3-[3-[(4-氯-2,5-二甲氧苯基)氨基]-1,3-二羰基丙基]苯基]-N2-(2-甲基丙酰)-N2-十八烷基-DL-天冬酰胺
• 英文名称: N-Methyl-pipecolinsaeure-hydrazid
• 英文别名: 1-methyl-piperidine-2-carboxylic acid hydrazide；1-Methylpiperidine-2-carbohydrazide
• CAS: 89856-16-6
• 化学式: C₇H₁₅N₃O
• mdl: MFCD09752001
• 分子量: 157.216
• InChiKey: SCDYQYASUAZAMO-UHFFFAOYSA-N

物化性质

• 沸点：
  316.3±31.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

文献信息

• Diazapane derivatives useful as antagonists of neurokinin 1 receptor and methods for their formation
  申请人：——

  公开号：US20020010174A1

  公开（公告）日：2002-01-24

  The invention relates to compounds of the formula 1 wherein R 1 , R 2 are independently from each other aryl or heteroaryl, wherein the heteroaryl group contains one or two heteroatoms, selected from N, O, or S, and wherein the aryl or heteroaryl groups are optionally substituted by 1 to 3 substituents, which are independently from each other halogen, CF 3 , lower alkoxy or lower alkyl; R 3 is hydrogen, lower alkyl, —(CH 2 ) n N(R) 2 , —(CH 2 ) n -heteroaryl or is a —(CH 2 ) n -non aromatic heterocycle, which heterocycles are optionally substituted by halogen, CF 3 , lower alkoxy or lower alkyl; R 4 is ═O, ═N(CH 2 ) n CH 3 or ═N(CH 2 ) n N(R) 2 ; R 3 and R 4 may be together with the N and C atoms to which they are attached the group —CR 5 ═N—N═; R 5 is hydrogen, —(CH 2 ) n N(R) 2 , —(CH 2 ) n -heteroaryl or is a —(CH 2 ) n -non aromatic heterocycle, which heterocycles are optionally substituted by halogen, CF 3 , lower alkoxy or lower alkyl; R is hydrogen or lower alkyl; n is 0, 1, 2 or 3; and pharmaceutically acceptable acid addition salts and enantiomeric forms thereof. The compounds are useful in the treatment of diseases, related to the NK-1 receptor.

  该发明涉及以下化合物的结构式1，其中R1、R2分别独立地为芳基或杂环芳基，其中杂环芳基含有一个或两个从N、O或S中选择的杂原子，而芳基或杂环芳基可选择地被1至3个取代基取代，这些取代基独立地为卤素、三氟甲基、低烷氧基或低烷基；R3为氢、低烷基、—(CH2)nN(R)2、—(CH2)n-杂环芳基或为—(CH2)n-非芳香杂环，这些杂环可选择地被卤素、三氟甲基、低烷氧基或低烷基取代；R4为HO、N(CH2)nCH3或N(CH2)nN(R)2；R3和R4可以与它们连接的N和C原子一起形成基团—CR5HN—NNH；R5为氢、—(CH2)nN(R)2、—(CH2)n-杂环芳基或为—(CH2)n-非芳香杂环，这些杂环可选择地被卤素、三氟甲基、低烷氧基或低烷基取代；R为氢或低烷基；n为0、1、2或3；以及其药学上可接受的酸盐和对映体形式。这些化合物在治疗与NK-1受体相关的疾病中是有用的。
• 1,6- Diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
  申请人：Patel Mahesh Vithalbhai

  公开号：US20140148431A1

  公开（公告）日：2014-05-29

  Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.

  公式（I）的化合物，其制备和在预防或治疗细菌感染中的应用被披露。
• 1H-INDOL-1-YL-UREA COMPOUNDS
  申请人：Brion Jean-Daniel

  公开号：US20090176794A1

  公开（公告）日：2009-07-09

  Compounds of formula (I): wherein: R 1 and R 2 , which may be the same or different, represent a hydrogen atom or a linear or branched (C 1 -C 6 )alkyl group, R 3 represents a hydrogen or halogen atom, a linear or branched (C 1 -C 6 )alkyl group, or a linear or branched (C 1 -C 6 )alkoxy group, Het represents a pyridyl, pyrimidinyl or piperidyl group, which are optionally substituted by one or more groups selected from halogen, linear or branched (C 1 -C 6 )alkyl and linear or branched (C 1 -C 6 )alkoxy, —represents a single bond or a double bond, their enantiomers and diastereoisomers, and also addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of depression, anxiety, disorders of memory in the course of aging and/or neurodegenerative diseases, and in the palliative treatment of Parkinson's disease, and for adaptation to stress.

  式（I）的化合物：其中：R1和R2，可以相同也可以不同，代表氢原子或线性或支链（C1-C6）烷基基团，R3代表氢或卤素原子，线性或支链（C1-C6）烷基基团，或线性或支链（C1-C6）烷氧基团，Het代表吡啶基、嘧啶基或哌啶基，可以选择地被一个或多个卤素、线性或支链（C1-C6）烷基和线性或支链（C1-C6）烷氧基团取代，—代表单键或双键，它们的对映异构体和顺反异构体，以及它们与药学上可接受的酸或碱形成的加合盐。含有该化合物的药物，可用于治疗抑郁症、焦虑症、老年记忆障碍和/或神经退行性疾病，以及对帕金森病的姑息治疗和适应应激。
• Nitrogen containing compounds
  申请人：PATEL Mahesh Vithalbhai

  公开号：US20150005285A1

  公开（公告）日：2015-01-01

  Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.

  本发明揭示了公式（I）的化合物，它们的制备以及在预防或治疗细菌感染方面的用途。
• NITROGEN CONTAINING COMPOUNDS
  申请人：PATEL Mahesh Vithalbhai

  公开号：US20150174133A1

  公开（公告）日：2015-06-25

  Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.

  公开了化学式(I)的化合物的制备和在预防或治疗细菌感染中的应用。