1-甲氧基-2-辛基苯 | 20056-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-甲氧基-2-辛基苯
• 英文名称: 1-methoxy-2-(n-octyl)benzene
• 英文别名: 2-Methoxy-1-octylbenzene；2-n-octylanisole；o-(n-Octyl)-anisol；o-n-Octyl-anisole；Anisole, o-octyl-；1-methoxy-2-octylbenzene
• CAS: 20056-59-1
• 化学式: C₁₅H₂₄O
• 分子量: 220.355
• InChiKey: JMDVVUPNWNPATJ-UHFFFAOYSA-N

物化性质

• 沸点：
  295.4±9.0 °C(Predicted)
• 密度：
  0.898±0.06 g/cm3(Predicted)
• LogP：
  6.310 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为产物：
  描述：

  1-methoxy-2-[(E)-oct-2-enyl]benzene 生成 1-甲氧基-2-辛基苯
  参考文献：
  名称：

  Smith Keith, Pollaud Guy M., J. Chem. Soc. Perkin Trans. 1, (1994) N 24, S 3519-3520

  摘要：

  DOI：

文献信息

• Highly Active Catalyst for the Heterogeneous Suzuki−Miyaura Reaction:  Assembled Complex of Palladium and Non-Cross-Linked Amphiphilic Polymer
  作者：Yoichi M. A. Yamada、Koji Takeda、Hideyo Takahashi、Shiro Ikegami

  DOI：10.1021/jo034354v

  日期：2003.10.1

  An assembled insoluble catalyst, PdAS, prepared from palladium ((NH4)2PdCl4 (1)) and non-cross-linked amphiphilic copolymer poly(N-isopropylacrylamide-co-4-diphenylstyrylphosphine) (2) was developed. It was found that PdAS is an excellent catalyst for the Suzuki-Miyaura reaction on three points: (1) The use of 8 x 10(-7) to 5 x 10(-4) mol equiv of PdAS afforded the coupling products efficiently after

  开发了由钯（（NH4）2PdCl4（1））和非交联两亲共聚物聚（N-异丙基丙烯酰胺-co-4-二苯基苯乙烯基膦）（2）制备的组装的不溶催化剂PdAS。已发现，PdAS在以下三个方面是铃木-宫浦反应的优良催化剂：（1）使用8 x 10（-7）到5 x 10（-4）摩尔当量的PdAS在偶联后有效地提供了偶联产物简单的后处理，营业额高达1,250,000。（2）催化剂可重复使用多次而不会损失催化活性。（3）PdAS在任何反应介质（即水或水性或无水有机溶剂）中均显示出良好的稳定性。对PdAS的分析研究表明2中的膦与钯配位形成PdCl2（PPh2Ar）2物种。
• Palladium-catalyzed cross-coupling reactions of B-alkyl-9-BBN or trialkylboranes with aryl and 1-alkenyl halides
  作者：Norio Miyaura、Tatsuo Ishiyama、Masako Ishikawa、Akira Suzuki

  DOI：10.1016/s0040-4039(00)87811-9

  日期：1986.1

  The reactions of trialkylboranes or B-alkyl-9-BBN with aryl and 1-alkenyl halides take place readily in the presence of PdCl2(dppf) and sodium hydroxide or methoxide to afford alkylated arenes and alkenes in excellent yields.

  在PdCl 2（dppf）和氢氧化钠或甲醇钠的存在下，三烷基硼烷或B-烷基-9-BBN与芳基和1-链烯基卤化物的反应很容易发生，以优异的收率得到烷基化的芳烃和烯烃。
• Tetraphosphine/palladium catalysed Suzuki cross-coupling reactions of aryl halides with alkylboronic acids
  作者：Isabelle Kondolff、Henri Doucet、Maurice Santelli

  DOI：10.1016/j.tet.2004.03.009

  日期：2004.4

  sphinomethyl)cyclopentane as a catalyst, a range of aryl bromides and chlorides undergoes Suzuki cross-coupling with alkylboronic acids in good yields. Several alkyl substituents such as ethyl, n-butyl, n-octyl, isobutyl or 2,2-dimethylpropyl on the alkylboronic acids have been successfully used. The functional group tolerance on the aryl halide is remarkable; substituents such as fluoro, methyl, methoxy

  通过使用[PdCl（C 3 H 5）] 2 /顺式，顺式，顺式-1,2,3,4-四（二苯基膦甲基）环戊烷作为催化剂，一系列芳基溴化物和氯化物进行铃木交叉偶联与烷基硼酸的收率很好。几个烷基取代基，例如乙基，正丁基，n已经成功地使用了烷基硼酸上的-辛基，异丁基或2，2-二甲基丙基。芳基卤对官能团的耐受性显着；可以容忍诸如氟，甲基，甲氧基，乙酰基，甲酰基，苯甲酰基，硝基或腈之类的取代基。此外，该催化剂即使在位阻芳基溴的反应中也可以低负荷使用。
• Metal cation-exchanged montmorillonite (Mn+-mont)-catalysed aromatic alkylation with aldehydes and ketones
  作者：Jun-ichi Tateiwa、Ei Hayama、Takahiro Nishimura、Sakae Uemura

  DOI：10.1039/a701744h

  日期：——

  The alkylation of aromatic compounds with aldehydes and ketones in the presence of a variety of metal cation-exchanged montmorillonites (Mn+-mont; Mn+ = Zr4+, Al3+, Fe3+, Zn2+, H+, Na+) has been investigated. Al3+- and Zr4+-Monts are revealed to be effective as catalysts, while no reaction takes place with Na+-mont. Al3+-Mont-catalysed alkylation of phenol with several aldehydes produces mainly or almost solely the corresponding gem-bis(hydroxyphenyl)alkanes (bisphenols) in good yields, while that with several ketones affords selectively the corresponding alkylphenols in moderate to good yields. The alkylation always occurs at the carbonyl carbon without any skeletal rearrangement and the kind of products depends much on the steric hindrance of an electrophilic intermediary carbocation. The alkylation of anisole, veratrole and p-cresol proceeds well, while that of toluene, benzene, chlorobenzene and nitrobenzene scarcely occurs.

  在各种金属阳离子交换的蒙脱石（Mn+-mont；Mn+ = Zr4+、Al3+、Fe3+、Zn2+、H+、Na+）存在下，研究了芳香化合物与醛和酮的烷基化反应。发现Al3+和Zr4+蒙脱石是有效的催化剂，而Na+蒙脱石则不发生反应。由Al3+蒙脱石催化的苯酚与几种醛的烷基化反应主要或几乎只生成了相应的双（羟苯基）烷烃（双酚），产率良好；而与几种酮的烷基化反应则选择性地生成了相应的烷基苯酚，产率适中至良好。烷基化总是发生在羰基碳上，没有骨架重排，产物的类型很大程度上取决于亲电中间体的碳正离子的空间位阻。茴香醚、邻苯二甲醚和对甲酚的烷基化反应良好进行，而甲苯、苯、氯苯和硝基苯的烷基化反应几乎不发生。
• Cobalt-catalyzed Cross-coupling Reactions of Aryl Bromides with Alkyl Grignard Reagents
  作者：Hiroyuki Hamaguchi、Minoru Uemura、Hiroto Yasui、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1246/cl.2008.1178

  日期：2008.11.5

  Aryl bromides react with primary alkyl Grignard reagents in the presence of N,N,N′,N′-tetramethyl-1,3-propanediamine and catalytic amounts of cobalt(II) chloride and an N-heterocyclic carbene to yi...

  在 N,N,N',N'-四甲基-1,3-丙二胺和催化量的氯化钴 (II) 和 N-杂环卡宾存在下，芳基溴化物与伯烷基格氏试剂反应生成...