1-联苯基-4-基-3-吗啉-4-基丙烷-1-醇盐酸 | 98484-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 中文名称: 1-联苯基-4-基-3-吗啉-4-基丙烷-1-醇盐酸
• 中文别名: 2,4-二甲基-1H-吡咯-1-胺
• 英文名称: N-Amino-2,4-dimethyl-pyrrol
• 英文别名: 1H-Pyrrol-1-amine, 2,4-dimethyl-；2,4-dimethylpyrrol-1-amine
• CAS: 98484-35-6
• 化学式: C₆H₁₀N₂
• 分子量: 110.159
• InChiKey: LZNXGQNDOGTWRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  31
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (Z)-5-Chloro-4-methyl-pent-3-en-2-one 在 一水合肼 作用下， 以 乙醇 为溶剂， 以50%的产率得到1-联苯基-4-基-3-吗啉-4-基丙烷-1-醇盐酸
  参考文献：
  名称：

  Heterocyclization of 1-alkyl-4-chlorobut-2-en-1-ones with hydrazine hydrate

  摘要：

  DOI：

  10.1007/bf00472762

文献信息

• GADZHILY, R. A.;FEDOSEEV, V. M.;NETKACHEVA, N. A.;AXMEDOVA, I. N.;SULTANO+, XIMIYA GETEROTSIKL. SOED.,(1989) N, S. 998
  作者：GADZHILY, R. A.、FEDOSEEV, V. M.、NETKACHEVA, N. A.、AXMEDOVA, I. N.、SULTANO+

  DOI：——

  日期：——
• [EN] MODULATORS OF G-PROTEIN COUPLED RECEPTORS<br/>[FR] MODULATEURS DE RÉCEPTEURS COUPLÉS À LA PROTÉINE
  申请人：CARMOT THERAPEUTICS INC

  公开号：WO2019183577A1

  公开（公告）日：2019-09-26

  This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize or partially agonize or antagonize) glucagon?like peptide?1 receptor ("GLP?1R") and/or the gastric inhibitory polypeptide receptor ("GIPR"). The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which modulation (e.g., agonism, partial agonism or antagonism) of GLP?1R and/or GIPR activities is benficial for the treatment or prevention of the underlying pathology and/or symptoms and/or progression of the disease, disorder, or condition. In some embodiments, the modulation results in an enhancment of (e.g., an increase in) existing levels (e.g., normal or below normal levels) of GLP?1R and/or GIPR activity (e.g., signaling). In some embodiments, the chemical entities described herein further modulate (e.g., attenuate, uncouple) -arrestin signaling relative to what is observed with the native ligand. This disclosure also features compositions as well as other methods of using and making the said chemical entities.
• Heterocyclization of 1-alkyl-4-chlorobut-2-en-1-ones with hydrazine hydrate
  作者：R. A. Gadzhily、V. M. Fedoseev、N. A. Netkacheva、Ch. N. Akhmedov、M. Sh. Sultanova

  DOI：10.1007/bf00472762

  日期：1989.7