1-[(2R)-2-(1H-indol-3-yl)-2-thiophen-2-ylethyl]-3-methylthiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[(2R)-2-(1H-indol-3-yl)-2-thiophen-2-ylethyl]-3-methylthiourea
• 化学式: C₁₆H₁₇N₃S₂
• 分子量: 315.5
• InChiKey: GUZPVCVUYQZXCX-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  100
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：HOX THERAPEUTICS LTD

  公开号：WO2018051114A1

  公开（公告）日：2018-03-22

  The present invention relates to compounds of Formula I or a pharmaceutically salt or solvate thereof, which impair PBX-dependent transcription regulation, particularly which affect the binding of HOX to PBX and their use in a number of applications, including the reduction of aberrant cell division, e.g. to treat certain cancers, and to maintain pluripotency of stem cells, e.g. to maintain the pluripotency of stem cells during culture expansion. wherein R1, R2 and R3 are as defined herein.

  本发明涉及公式I的化合物或其药用盐或溶剂，其影响PBX依赖的转录调控，特别是影响HOX与PBX的结合，并在许多应用中使用，包括减少异常细胞分裂，例如治疗某些癌症，并保持干细胞的多能性，例如在培养扩增期间保持干细胞的多能性。其中R1、R2和R3如本文所定义。
• ORGANIC COMPOUNDS
  申请人：HOX THERAPEUTICS LIMITED

  公开号：US20190256502A1

  公开（公告）日：2019-08-22

  The present invention relates to compounds of Formula I or a pharmaceutically salt or solvate thereof, which impair PBX-dependent transcription regulation, particularly which affect the binding of HOX to PBX and their use in a number of applications, including the reduction of aberrant cell division, e.g. to treat certain cancers, and to maintain pluripotency of stem cells, e.g. to maintain the pluripotency of stem cells during culture expansion. wherein R 1 , R 2 and R 3 are as defined herein.