10-氨基-10-氧代癸酸 | 6249-07-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 10-氨基-10-氧代癸酸
• 英文名称: 1,10-decandioic acid monoamide
• 英文别名: 9-carbamoyl-nonanoic acid；9-Carbamoyl-nonansaeure；Sebacamic acid；10-amino-10-oxodecanoic acid
• CAS: 6249-07-6
• 化学式: C₁₀H₁₉NO₃
• 分子量: 201.266
• InChiKey: FYGFTTWEWBXNMP-UHFFFAOYSA-N

物化性质

• 熔点：
  126-128 °C
• 沸点：
  425.7±28.0 °C(Predicted)
• 密度：
  1.064±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-酮丁酸 、 10-氨基-10-氧代癸酸 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以2%的产率得到9-(1-Carboxy-propenylcarbamoyl)-nonanoic acid
  参考文献：
  名称：

  Inhibition of the mammalian .beta.-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids

  摘要：

  The title enzyme deactivates the potent carbapenem antibiotic imipenem in the kidney, producing low antibiotic levels in the urinary tract. A series of (Z)-2-(acylamino)-3-substituted-propenoic acids (3) are specific, competitive inhibitors of the enzyme capable of increasing the urinary concentration of imipenem in vivo. Many of the compounds were prepared in one step from an alpha-keto acid and a primary amide. The optimum R2 groups are 2,2-dimethyl, -dichloro, and -dibromocyclopropyl. With R2 = 2,2-dimethylcyclopropyl (DMCP), a wide variety of R3 groups including alkyl, oxa- and thiaalkyl, and alkyl groups containing acidic, basic, and neutral substituents give effective inhibitors with Ki values of 0.02-1 microM and a range of pharmacokinetic properties. By resolution of enantiomers and X-ray crystallography, the enzyme-inhibitory activity of the DMCP group was found to reside with the 1S isomer. The cysteinyl compound 176 (cilastatin, MK-0791) has the desired pharmacological properties and has been chosen for combination with imipenem.

  DOI：

  10.1021/jm00389a018
• 作为产物：
  描述：

  癸二酸二乙酯 在 氨 作用下， 生成 10-氨基-10-氧代癸酸
  参考文献：
  名称：

  Rowney, Justus Liebigs Annalen der Chemie, 1852, vol. 82, p. 123

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS AND METHODS OF TREATING CANCERS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE CANCERS
  申请人：CULLGEN SHANGHAI INC

  公开号：WO2020200291A1

  公开（公告）日：2020-10-08

  This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.

  这份披露涉及异双功能化合物（例如，双功能小分子化合物），包括一种或多种异双功能化合物的组合物，以及使用这些异双功能化合物治疗患有特定疾病的需要该类治疗的受试者的方法。该披露还涉及识别此类异双功能化合物的方法。
• Heterolytic (2 e) vs Homolytic (1 e) Oxidation Reactivity: N−H versus C−H Switch in the Oxidation of Lactams by Dioxirans
  作者：Cosimo Annese、Lucia D'Accolti、Caterina Fusco、Giulia Licini、Cristiano Zonta

  DOI：10.1002/chem.201604507

  日期：2017.1.5

  in the oxidation of lactams moving from dimethyl dioxirane (DDO) to methyl(trifluoromethyl)dioxirane (TFDO). A physical organic chemistry study, which combines the oxidation with two other dioxiranes methyl(fluoromethyl)dioxirane, MFDO, and methyl(difluoromethyl)dioxirane, DFDO, with computational studies, points to a diverse ability of the dioxiranes to either stabilize the homo or the heterolytic

  二恶英是强大的氧化剂，可通过两种不同的机制起作用：1）均溶（H提取和氧回弹）和2）杂溶（亲电子氧化）。迄今为止，已经报道了底物的性质决定了反应模式，而与所使用的二环氧乙烷无关。在此，我们报道了前所未有的情况，其中二环氧乙烷的性质决定了氧化化学选择性。特别是，在内酰胺从二甲基二环氧乙烷（DDO）转移到甲基（三氟甲基）二环氧乙烷（TFDO）的内酰胺氧化中观察到了从CH到NH的转换。一项物理有机化学研究，将氧化与其他两种二氧杂环戊烷甲基（氟甲基）二环氧乙烷，MFDO和甲基（二氟甲基）二环氧乙烷相结合，通过计算研究，DFDO指出二恶英类化合物具有稳定同源或杂合途径的多种能力。
• Polymeric amides from omega-amino acids
  作者：D. D. Coffman、N. L. Cox、E. L. Martin、W. E. Mochel、F. J. Van Natta

  DOI：10.1002/pol.1948.120030110

  日期：1948.2

  Methods for the preparation of fiber-forming polymeric amides from ω-amino acids and The variation in melting points of the polymeric their amide-forming derivatives are described. The variation in melting points of the polymeric amides with increasing chain length of the recurring unit is discussed.

  描述了由ω-氨基酸制备成纤维的聚合酰胺的方法和聚合的它们的酰胺形成衍生物的熔点变化。讨论了聚合酰胺的熔点随重复单元链长的增加而变化。
• Toner and toner production method
  申请人：Canon Kabushiki Kaisha

  公开号：EP2701008A1

  公开（公告）日：2014-02-26

  The present invention provides a toner having superior color development property and a method of producing a toner having favorable particle size distribution and color development property, in which the toner containing a binder resin and a colorant that contains a phthalocyanine pigment represented by general formula (1), and the method for producing the toner.

  本发明提供了一种具有优越的色彩发展性能的调色剂以及一种制备具有良好颗粒大小分布和色彩发展性能的调色剂的方法，其中该调色剂包含一种含有通式（1）所表示的菲洛蓝素颜料的粘合剂树脂和着色剂，以及制备该调色剂的方法。
• Method for producing expandable thermoplastic polymer particles
  申请人：KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0396046A2

  公开（公告）日：1990-11-07

  The present invention provides a method for producing expandable thermoplastic polymer particles which comprises conducting polymerization by adding a polymerizable monomer either continuously or intermittently to thermoplastic polymer particles having a uniform particle size suspended in water,characterized in that an amide compound is added when the added amount of the polymerizable monomer is not more than one half of the total amount to be added in the course of polymerization and resulting polymer particles are impregnated with an easily volatile blowing agent after completion of addition of the amide compound and the polymerizable monomer. According to the present invention, expandable thermoplastic particles which are capable of giving cells, fine and uniform in size, are obtainable even by expanding immediately after production without any aging period.

  本发明提供了一种生产可膨胀热塑性聚合物颗粒的方法，该方法包括通过连续或间歇地向悬浮在水中的粒度均匀的热塑性聚合物颗粒中加入可聚合单体进行聚合，其特征在于，当加入的可聚合单体量不超过聚合过程中加入总量的一半时，加入酰胺化合物，在完成酰胺化合物和可聚合单体的加入后，用易挥发性发泡剂浸渍得到的聚合物颗粒。根据本发明，即使在生产后立即膨胀，也无需任何老化期，即可获得可膨胀热塑性粒子，这种粒子能够形成细小均匀的细胞。