12-羟基硬脂酸辛酯 | 74819-90-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 12-羟基硬脂酸辛酯
• 中文别名: 2-甲酯基&lt甲氧羰基&gt-3-(4-氟苯基)-N-丙基去甲莨菪烷
• 英文名称: 12-hydroxy-octadecanoic acid octyl ester
• 英文别名: 12-Hydroxy-stearinsaeure-octylester；12-Hydroxy-octadecansaeure-octylester；Octyl 12-hydroxyoctadecanoate
• CAS: 74819-90-2
• 化学式: C₂₆H₅₂O₃
• 分子量: 412.697
• InChiKey: ASUSBOZIBYQNDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  29
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cosmetic or pharmaceutical composition, to be applied topically
  申请人：Kuhs GmbH

  公开号：US10660831B2

  公开（公告）日：2020-05-26

  A cosmetic or pharmaceutical composition, to be applied topically is described, which has a hydrophilic outer phase, at least one cosmetic and/or pharmaceutical active ingredient and at least one carrier substance for the active ingredient. The carrier substance here forms such structures, which comprises at least two lamellar double membrane layers arranged one over another in the manner of a sandwich, wherein between adjacent double membrane layers, aligned parallel to each other, a layer of an inner phase is respectively arranged. The active ingredient is distributed in the double membrane layer and in the layer of the inner phase such that the layer of the inner phase contains the active ingredient in a concentration range between 2% by weight and 98% by weight and the double membrane layer contains the active ingredient in a concentration between 98% by weight and 2% by weight, respectively in relation to the total concentration of active ingredient, and the outer phase has no or almost no active ingredient.

  本文描述了一种局部使用的化妆品或药物组合物，该组合物具有亲水性外相、至少一种化妆品和/或药物活性成分以及至少一种活性成分的载体物质。载体物质在这里形成这样的结构，它包括至少两个层状双膜层，以三明治的方式一层一层地排列，其中在相邻的双膜层之间，平行排列着一层内相。活性成分分布在双膜层和内相层中，使内相层中活性成分的浓度范围介于 2%（重量）和 98%（重量）之间，双膜层中活性成分的浓度范围介于 98%（重量）和 2%（重量）之间，分别与活性成分的总浓度有关，而外相中没有或几乎没有活性成分。
• DIELECTRIC FLUID COMPOSITIONS FOR ENHANCED THERMAL MANAGEMENT
  申请人：Dow Global Technologies LLC

  公开号：EP2751810A1

  公开（公告）日：2014-07-09
• NANOPARTICLES CONTAINING NICOTINE AND/OR COTININE, DISPERSIONS, AND USE THEREOF
  申请人：Lautenschlager Hans

  公开号：US20100247653A1

  公开（公告）日：2010-09-30

  The present invention relates to nanoparticles containing nicotine and/or cotinine. The present invention further relates to dispersions containing these nanoparticles. The invention relates in particular to corresponding novel transdermal pharmaceuticals containing nicotine and cotinine in nanoparticulate form, and use thereof for smoking cessation.
• COSMETIC OR PHARMACEUTICAL COMPOSITION FOR TOPICAL APPLICATION
  申请人：Albrecht Martin

  公开号：US20110027327A1

  公开（公告）日：2011-02-03

  A cosmetic or pharmaceutical composition, to be applied topically is described, which has a hydrophilic outer phase, at least one cosmetic and/or pharmaceutical active ingredient and at least one carrier substance for the active ingredient. The carrier substance here forms such structures, which comprises at least two lamellar double membrane layers arranged one over another in the manner of a sandwich, wherein between adjacent double membrane layers, aligned parallel to each other, a layer of an inner phase is respectively arranged. The active ingredient is distributed in the double membrane layer and in the layer of the inner phase such that the layer of the inner phase contains the active ingredient in a concentration range between 2% by weight and 98% by weight and the double membrane layer contains the active ingredient in a concentration between 98% by weight and 2% by weight, respectively in relation to the total concentration of active ingredient, and the outer phase has no or almost no active ingredient.
• PHARMACEUTICAL COMPOSITION FOR TOPICAL APPLICATION
  申请人：ALBRECHT Martin

  公开号：US20130028947A1

  公开（公告）日：2013-01-31

  A topical pharmaceutical composition which has a hydrophilic outer phase, at least one pharmaceutical active ingredient and at least one carrier substance. The carrier substance has at least two lamellar double membrane layers arranged one over another in the manner of a sandwich, wherein between adjacent double membrane layers, aligned parallel to each other, a layer of an inner phase is arranged. The active ingredient is distributed in the double membrane layer and in the layer of the inner phase such that the layer of the inner phase contains the active ingredient in a concentration range between 2% by weight and 98% by weight and the double membrane layer contains the active ingredient in a concentration between 98% by weight and 2% by weight, and the outer phase has no or almost no active ingredient.