19-羟基-十九烷酸 | 22438-61-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 19-羟基-十九烷酸
• 中文别名: 19-羟基十九酸
• 英文名称: 19-hydroxynonadecanoic acid
• 英文别名: ω-Oxy-nonadecylsaeure；18-Oxy-octadecan-carbonsaeure-(1)；19-Hydroxy-nonadecansaeure；ς-Oxy-nonadecylsaeure
• CAS: 22438-61-5
• 化学式: C₁₉H₃₈O₃
• 分子量: 314.509
• InChiKey: LSEAKSNIGVHVQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  19-羟基-十九烷酸 在 dealuminated HY zeolite 作用下， 以 甲苯 为溶剂， 反应 72.0h， 以45%的产率得到oxacycloicosan-2-one
  参考文献：
  名称：

  Zeolite-catalyzed macrolactonization of ω-hydroxyalkanoic acids in a highly concentrated solution

  摘要：

  Lactonization of 15-hydroxypentadecanoic acid to 15-pentadecanolide on deluminated HY zeolite was successfully performed in a concentrated toluene solution (0.2 M). Addition of a bulky organic base to the reaction system suppressed the lactonization. It was concluded that the lactonization was promoted at specific acid sites on the external surface of the zeolite. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10545-7
• 作为产物：
  描述：

  Carbomethoxyoctadecyl acetate 生成 19-羟基-十九烷酸
  参考文献：
  名称：

  Ucciani,E. et al., Bulletin de la Societe Chimique de France, 1969, p. 2826 - 2830

  摘要：

  DOI：

文献信息

• Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
  申请人：BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

  公开号：US20160221925A1

  公开（公告）日：2016-08-04

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycystic ovarian syndrome, cancer, and inflammatory disorders—using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  该发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于诊断和治疗各种疾病的方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病等；以及筛选可用于治疗这些疾病和/或调节FAHFA水平、FAHFA介导信号传导和FAHFA介导生物效应的其他化合物的方法。
• [EN] LIPIDS THAT INCREASE INSULIN SENSITIVITY AND METHODS OF USING THE SAME<br/>[FR] LIPIDES AUGMENTANT LA SENSIBILITÉ À L'INSULINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BETH ISREAL DEACONESS MEDICAL CT INC

  公开号：WO2013166431A1

  公开（公告）日：2013-11-07

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders- including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders— using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  这项发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于治疗各种疾病的诊断和治疗方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病，以及使用它们的方法；以及筛选对这些疾病有用或调节FAHFA水平、FAHFA介导的信号传导和FAHFA介导的生物效应的其他化合物的方法。
• 20-HETE antagonists and agonists
  申请人：——

  公开号：US20020049244A1

  公开（公告）日：2002-04-25

  20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.

  20-HETE激动剂和拮抗剂以及其治疗应用已被披露。在本发明的一种优选形式中，20-HETE激动剂被选自包括21-羟基油酸-5(Z), 8(Z),11(Z),14(Z)-四烯酸，20-羟基二十碳-5(Z),14(Z)-二烯酸和20-,21-二甲基20-HETE的组中。优选的20-HETE拮抗剂包括5(S)-HETE，15(S)-HETE，19(S)-HETE，19-羟基十九酸-5(Z),8(Z),11(Z),14(Z)-四烯酸和20-羟基二十碳-6(Z),15(Z)-二烯酸。
• Highly Regioselective Isomerizing Hydroformylation of Long-Chain Internal Olefins Catalyzed by a Rhodium Bis(Phosphite) Complex
  作者：Swechchha Pandey、Samir H. Chikkali

  DOI：10.1002/cctc.201500743

  日期：2015.11

  single‐step synthesis, coordination behavior, and application of a bis(phosphite) ligand in the isomerizing hydroformylation of internal olefins was investigated. Interestingly, high‐pressure NMR spectroscopy investigations revealed unexpected inequivalency of the two phosphorus nuclei, which display bisequatorial coordination of the bis(phosphite) ligand in a trigonal bipyramidal rhodium complex. Upon

  研究了单（亚磷酸酯）配体的单步合成，配位行为及其在内烯烃异构化加氢甲酰化中的应用。有趣的是，高压NMR光谱研究揭示了两个磷核的意料之外的不等价性，它们显示了三角双锥体铑络合物中双（亚磷酸酯）配体的双谱位配位。在使用极富挑战性的植物油衍生的底物油酸甲酯进行异构化加氢甲酰化后，双（亚磷酸酯）铑络合物显示出前所未有的75％的线性选择性。
• [EN] DRUG CONJUGATES<br/>[FR] CONJUGUÉS DE MÉDICAMENT
  申请人：UNIV MISSOURI

  公开号：WO2009158633A1

  公开（公告）日：2009-12-30

  Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided.

  提供了包含治疗或诊断药物与细胞膜转运体或受体的底物通过亲脂性连接剂连接的共轭化合物。