氯二乙氧基苯基硅烷 | 17903-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯二乙氧基苯基硅烷
• 英文名称: phenyldiethoxychlorosilane
• 英文别名: chloro-diethoxy-phenylsilane
• CAS: 17903-53-6
• 化学式: C₁₀H₁₅ClO₂Si
• 分子量: 230.766
• InChiKey: LEYKSONZGURWNL-UHFFFAOYSA-N

物化性质

• 沸点：
  92-93 °C(Press: 4 Torr)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.14
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  氯二乙氧基苯基硅烷 在 正丁基锂 、 三氟化硼乙醚 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 10.08h， 生成 difluorophenyl[2-((E)-phenylazo)phenyl]silane
  参考文献：
  名称：

  带有 2-(苯基偶氮)苯基的有机硅化合物中硅配位数的可逆光开关

  摘要：

  由相应的氯硅烷和通过 2-碘代偶氮苯的卤素-锂金属转移制备的 2-硫代偶氮苯合成了几种带有 2-(苯基偶氮)苯基的有机硅化合物。它们的结构由 (1) H、(13) C、(19) F 和 (29) Si NMR 光谱、UV-vis 光谱和 X 射线晶体学分析确定。在紫外-可见光谱中，与未取代的偶氮苯的跃迁相比，甲硅烷基导致偶氮基团的 n-pi 和 pi-pi 跃迁发生红移。氟硅烷的 E 异构体表现出偶氮基团的氮原子和硅原子之间的分子内相互作用，导致它们的中间结构介于扭曲的三角双锥结构和围绕硅原子的四面体结构之间，X 射线晶体学分析和核磁共振谱揭示了这一点。另一方面，没有氟原子的硅烷在没有这种相互作用的情况下显示出四面体结构。氟硅烷的 E-异构体的光辐照以良好的产率可逆地提供相应的 Z-异构体。通过(29)Si NMR光谱发现Z-异构体的硅原子在不存在Si-N相互作用的情况下是四配位的。通过光照射，氟硅烷的硅原子的配位数在

  DOI：

  10.1021/ja060926s
• 作为产物：
  描述：

  diethoxy(phenyl)silane 在 三氯异氰尿酸 作用下， 以 二氯甲烷 为溶剂， 以98%的产率得到氯二乙氧基苯基硅烷
  参考文献：
  名称：

  Utility of trichloroisocyanuric acid in the efficient chlorination of silicon hydrides

  摘要：

  The potential of trichloroisocyanuric acid (TCCA) as a chlorination agent for efficient conversion of Si-H functional silanes and siloxanes to the corresponding Si-Cl functional moieties was explored. In comparison to methods using other chlorinating agents, TCCA is inexpensive, results in a much faster reaction and produces a high purity product with a conversion that is essentially quantitative. A variety of chloro derivatives of linear and cyclic structures have been synthesized from silicon hydrides using this reagent with impressive yields that typically exceed 90%: PhSiCl3 (97.5%); PhMeSiCl2 (95.5%); Ph3SiCl (97.5%); Vi(3)SiCl (98.7%); (EtO)(3)SiCl (99.7%); t-Bu3SiCl (similar to 100%); (MeClSiO)(4) (86.5%); (MeClSiO)(5) (95%); (MeClSiO)(7) (96.5%); Ph(OEt)(2)SiCl (98%); ClMe2SiOSiMe2Cl (98.6%); ClMe2SiOSiMeClOSiMe2Cl (94.6%); ClMe2Si(OSiMeCl)(2)OSiMe2C l (92.3%); (Me3SiO)(3)SiCl (97%); Me3SiOSiClPhOSiMe3 (99%); Me3SiO(SiMeClO)(3)SiMe3 (95.7%); ClSi(OSiMe3)(2)OSi(OSiMe3) Cl-2 (93.6%).For monohydridosilanes, dichloromethane (CH2Cl2) was a suitable solvent in which nearly quantitative conversion was observed within several minutes following the addition of the silanes to TCCA. For certain cyclic and linear siloxanes, and especially silanes containing multiple hydrogen atoms on the same silicon for which the reaction is sluggish in CH2Cl2, tetrahydrofuran (THF) was the preferred solvent. For a sterically demanding silane that did not undergo chlorination even in THF viz., HSi(OSiMe3)(2)O-Si(OSiMe3)(2)H, 1,2-dichloroethane was the best solvent. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2006.12.032

文献信息

• Psychological reactions and quality of life in patients with posterior uveal melanoma treated with ruthenium plaque therapy or enucleation: A one year follow-up study
  作者：Yvonne Brandberg、Erik Kock、Kristi Oskar、Eva Af Trampe、Stefan Seregard

  DOI：10.1038/eye.2000.233

  日期：2000.11

  Purpose To investigate psychological reactions and quality of life among patients with posterior uveal melanoma. Methods Consecutive patients with uveal malignant melanoma (99/106), referred to st Erik's Eye Hospital 1995–1996, treated with rutheniuim plaque radiotherapy (n = 50) or enucleation (n = 49), were included in this non-randomised prospective comparative study. Questionnaires were completed before treatment (Hospital Anxiety and Depression Scale, HAD scale) and 2 and 12 months after diagnosis including the HAD scale, the Impact of Event Scale and the EORTC QLQ-C30. A disease-specific questionnaire was included 12 months after diagnosis. Between-group differences were analysed by chi-square, Student's t-test and ANOVA. Results A majority of the patients reported reduced ‘Quality of Life’ (72–85%), ‘Emotional functioning’ (60–74%) and ‘Cognitive functioning’ (51–61%). ‘Fatigue’ was the most frequently reported symptom (61–72%) followed by ‘Insomnia’ (43–58%). Anxiety and depressive symptoms were relatively frequent up to 1 year after treatment, but the levels of anxiety decreased during the first year after treatment. Disease and treatment-related problems were reported in both treatment groups 1 year after diagnosis. Enucleated patients had more problems with appearance and judging distances, whereas those treated with radiotherapy reported vision impairment to a higher extent. Conclusion Enucleated patients reported high levels of emotional distress, problems with appearance and judging distances during the first year after treatment. Patients treated with radiotherapy reported similar levels of quality of life and emotional problems, but more problems with visual impairment. These differences in impact on disease-related functioning should be taken into account when treatment options are discussed.

  目的：调查后葡萄膜黑色素瘤患者的心理反应和生活质量。方法：本研究纳入了1995年至1996年间转诊至St Erik's眼科医院的连续患者（99/106），患有恶性葡萄膜黑色素瘤，接受了铑 Plaque放射治疗（n = 50）或眼球摘除术（n = 49），为一项非随机前瞻性比较研究。患者在治疗前（医院焦虑与抑郁量表HAD）以及确诊后2个月和12个月完成问卷，包括HAD量表、创伤后应激影响量表（Impact of Event Scale）和EORTC QLQ-C30。在确诊后12个月还包括了一份疾病特定问卷。通过卡方检验、斯图dent的t检验和方差分析（ANOVA）分析组间差异。结果：大多数患者报告感到生活质量下降（72%–85%）、情感功能下降（60%–74%）和认知功能下降（51%–61%）。疲劳是最常报告的症状（61%–72%），其次是失眠（43%–58%）。焦虑和抑郁症状在治疗后的一年内相对频繁，但焦虑水平在治疗后的第一年内有所降低。确诊后一年，两个治疗组均报告了与疾病和治疗相关的问题。眼球摘除的患者在外貌和判断距离方面问题较多，而接受放疗的患者则在视力障碍方面报告得更为严重。结论：眼球摘除的患者在治疗后的第一年内报告了较高的情感痛苦、外貌和判断距离的问题。接受放疗的患者报告了类似的生活质量和情感问题，但在视力障碍方面问题更多。讨论治疗选项时，应考虑到这些对疾病相关功能的影响差异。
• High Performance of Si–O–Ti Bonds for Anchoring Sensitizing Dyes on TiO₂Electrodes in Dye-sensitized Solar Cells Evidenced by Using Alkoxysilylazobenzenes
  作者：Kenji Kakiage、Masaki Yamamura、Emi Fujimura、Toru Kyomen、Masafumi Unno、Minoru Hanaya

  DOI：10.1246/cl.2010.260

  日期：2010.3.5

  Applicability of alkoxysilyl group was examined for the first time as the anchor moiety of sensitizing dyes for dye-sensitized solar cells by using alkoxysilylazobenzenes. Alkoxysilylazobenzenes adsorbed efficiently onto TiO2 electrodes by the formation of Si–O–Ti bonds, and the electrodes exhibited much higher durability to water and better photovoltaic performance than in the case of a conventional carboxy dye.

  通过使用烷氧基硅基偶氮苯，首次研究了烷氧基硅基作为染料敏化太阳能电池敏化染料的锚基的适用性。与传统的羧基染料相比，烷氧基硅基偶氮苯通过形成 Si-O-Ti 键有效地吸附在二氧化钛电极上，电极对水的耐久性更高，光电性能更好。
• Molchanov, B. V.; Ryzhova, O. G.; Chernyshev, E. A., Journal of general chemistry of the USSR, 1985, vol. 55, # 9, p. 1850 - 1852
  作者：Molchanov, B. V.、Ryzhova, O. G.、Chernyshev, E. A.、Ivanov, V. I.、Kovalenko, V. I.

  DOI：——

  日期：——
• Chernyshev, E. A.; Komalenkova, N. G.; Tagachenkov, A. A., Russian Journal of General Chemistry, 1995, vol. 65, # 2.2, p. 241 - 243
  作者：Chernyshev, E. A.、Komalenkova, N. G.、Tagachenkov, A. A.、Bykovchenko, V. G.

  DOI：——

  日期：——
• Synthesis of Bis(diethoxymethylsilyl) Derivatives of 4,4'-Dibromobiphenyl, 4-Bromophenyl Ether, α,p-Dibromotoluene, and 1,6-Dibromohexane¹
  作者：L. W. BREED

  DOI：10.1021/jo01077a032

  日期：1960.7