2,2-二乙基环丙烷羧酸 | 108420-15-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,2-二乙基环丙烷羧酸
• 英文名称: 2,2-diethyl-cyclopropanecarboxylic acid
• 英文别名: 2,2-Diaethyl-cyclopropancarbonsaeure；1,1-diethylcarboxy cyclopropane；2,2-Diethylcyclopropanecarboxylic acid；2,2-diethylcyclopropane-1-carboxylic acid
• CAS: 108420-15-1
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: VVIHKNHVJCKLQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  220.5±8.0 °C(Predicted)
• 密度：
  1.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2916209090

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 2,2-二乙基环丙烷-1-甲酰胺 、 2,2-二乙基环丙烷羧酸
  参考文献：
  名称：

  Synthesis of 2,2-Dialkylcyclopropane Nitriles¹

  摘要：

  DOI：

  10.1021/ja01570a041

文献信息

• Process for the production of substituted cyclopropane derivatives
  申请人：——

  公开号：US04154952A1

  公开（公告）日：1979-05-15

  Substituted cyclopropane derivatives are prepared in one step by interreacting an aldehyde, an active methylene compound, a sulfoxonium or sulfonium bromide or iodide, and a strong base in a reaction-inert organic solvent.

  通过在反应惰性有机溶剂中使醛、活性甲基化合物、亚砜或磺酸盐溴化物或碘化物以及强碱相互作用，可以一步制备取代环丙烷衍生物。
• [EN] SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DES VIRUS ÉBOLA ET DE LA FIÈVRE DE LASSA, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HARVARD COLLEGE

  公开号：WO2019051396A1

  公开（公告）日：2019-03-14

  Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: formula (I), wherein A is N or CR8; Z is formula (II); E is selected from optionally substituted alkyl, cycloalkyl, arylalkyl, cycloalkylalkyl, amino, alkoxy, cycloalkyloxy, and cycloalkylamino; R1 is selected from optionally substituted aryl and heteroaryl, R2 and R3 are independently selected from H, deutero, optionally substituted alkyl, haloalkyl, or R2 and R3, together with the carbon to which they are bound, combine to form a carbonyl; and R8 is selected from H, deutero, halo, hydroxyl, cyano, amino, alkyl, alkoxy, carboxy, alkoxycarbonyl, and aminocarbonyl, provided that E is not formula (III).

  本文揭示了具有以下结构的化合物，以及用于治疗疾病或感染（如病毒感染（例如埃博拉）、癌症和肥胖）的组合物和方法：式（I），其中A为N或CR8；Z为式（II）；E选自可选择取代的烷基、环烷基、芳基烷基、环烷基烷基、氨基、烷氧基、环烷氧基和环烷基氨基；R1选自可选择取代的芳基和杂环芳基，R2和R3分别选自H、氘、可选择取代的烷基、卤代烷基，或R2和R3与其结合的碳共同形成羰基；R8选自H、氘、卤、羟基、氰基、氨基、烷基、烷氧基、羧基、烷氧羰基和氨基羰基，但E不是式（III）。
• SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE
  申请人：President and Fellows of Harvard College

  公开号：US20210163454A1

  公开（公告）日：2021-06-03

  Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: wherein A is N or CR 8 ; Z is E is selected from optionally substituted alkyl, cycloalkyl, arylalkyl, cycloalkylalkyl, amino, alkoxy, cycloalkyloxy, and cycloalkylamino; R 1 is selected from optionally substituted aryl and heteroaryl, R 2 and R 3 are independently selected from H, deutero, optionally substituted alkyl, haloalkyl, or R 2 and R 3 , together with the carbon to which they are bound, combine to form a carbonyl; and R 8 is selected from H, deutero, halo, hydroxyl, cyano, amino, alkyl, alkoxy, carboxy, alkoxycarbonyl, and aminocarbonyl, provided that E is not
• US4154952A
  申请人：——

  公开号：US4154952A

  公开（公告）日：1979-05-15
• Synthesis of 2,2-Dialkylcyclopropane Nitriles¹
  作者：Edward R. Nelson、M. Maienthal、L. A. Lane、A. A. Benderly

  DOI：10.1021/ja01570a041

  日期：1957.7