2,2-硫双(5-氨基苯磺酸) | 118-86-5

• 物质功能分类: 化学试剂 - 有机试剂
• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2,2-硫双(5-氨基苯磺酸)
• 中文别名: 2,2'-硫双(5-氨基苯磺酸)
• 英文名称: 5,5'-diamino-2,2'-sulfanediyl-bis-benzenesulfonic acid
• 英文别名: 5,5'-Diamino-2,2'-sulfandiyl-bis-benzolsulfonsaeure；4.4'-Diamino-diphenylsulfid-disulfonsaeure-(2.2')；2,2'-thiobis(5-aminobenzenesulfonic) acid；4,4'-diaminodiphenyl sulphide-2,2'-disulphonic acid；Benzenesulfonic acid, 2,2'-thiobis[5-amino-；5-amino-2-(4-amino-2-sulfophenyl)sulfanylbenzenesulfonic acid
• CAS: 118-86-5
• 化学式: C₁₂H₁₂N₂O₆S₃
• 分子量: 376.435
• InChiKey: CHBFUBKXMBQCKO-UHFFFAOYSA-N

物化性质

• 密度：
  1.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  203
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2,2-硫双(5-氨基苯磺酸) 生成 4-(4-diazonio-2-sulfophenyl)sulfanyl-3-sulfobenzenediazonium;dichloride
  参考文献：
  名称：

  KOZLOVA, T. E.;SUVEREVA, V. K.;MURZINA, L. V.;XVOROSTOVA, YU. T., PERM. GOS. PED. IN-T, PERM,(1988) 9 S., IL., ONIITEHXIM G. CHERKASSY, 68+

  摘要：

  DOI：
• 作为产物：
  描述：

  4,4-二氨基二苯硫醚 在 硫酸 作用下， 生成 2,2-硫双(5-氨基苯磺酸)
  参考文献：
  名称：

  Schmidt, Chemische Berichte, 1906, vol. 39, p. 615

  摘要：

  DOI：

文献信息

• [EN] ARYL SULFONIC ACIDS AND DERIVATIVES AS FSH ANTAGONISTS<br/>[FR] ACIDES SULFONIQUES ARYLES ET DERIVES TELS QUE LES ANTAGONISTES FSH
  申请人：AMERICAN HOME PROD

  公开号：WO2000058277A1

  公开（公告）日：2000-10-05

  This invention provides compounds of formula (I) having the structure wherein Q is hydrogen or -SO2R1; X is a bond, O, S(O)¿n?, -CH=CH-, -CH2CH2-, -C C-, or -CH2S(O)nCH2-; R?1¿ is OH, NH¿2?, C1 to C6 alkoxy, C1 to C3 perfluoroalkoxy; Ar is (a) or (b); Ar' is (c) or (d); R?2 and R4¿ are each, independently, hydrogen, OR6, -S(O)¿m?R?6, -NHR6, -N(R6)¿2, or -CH2SO2CH3; R?3 and R5¿ are each, independently, hydrogen, -NO¿2?, -NH2, -SO2R?9¿, or -CH¿2R?9; R6 is hydrogen, C¿1? to C6 alkyl, C3 to C6 alkenyl, -CH2CH2Z, -CH2COR?7, -CH¿2CH=CHCOR7, (e), (f) or (g); Y¿1? and Y?3¿ are each, independently, N, or CH; Y?2 and Y4¿ are each independently, O, S, or NR?13; R7 is -OR8, -NHR8, -N(R8)¿2, or -NHCH2CH2OR8; Z is -OR¿8?, -OCH2CH2OR?8, -N(R8)¿2, or (h); R8 is hydrogen or C1 to C3 alkyl; R9 is C1 to C6 alkyl, C3 to C6 alkenyl, OH, NHR?10, N(R10)¿2, CH2COR11, -CH2CH=CHCOR11, or (i); R10 is C1 to C3 alkyl, C3 to C4 alkenyl, phenyl, -CH2CH2OCH3, or -(j); R?11 is -OR12, -NHR12, -N(R12)¿2, or -NHCH2CH2OR12; R12 is hydrogen, or C¿1? to C3 alkyl; R?13¿ is hydrogen, or C¿1? to C3 alkyl; W is a bond, CH2, CH2CH2, O, S(O)q, NCHO, NCOCH3, or NR?12¿; m is 0 - 2; n is 0 - 2; q is 0 - 2, with the proviso that R?2 and R3¿ are not both hydrogen; or pharmaceutically acceptable salt thereof, which are useful as contraceptive agents.

  本发明提供了具有结构式(I)的化合物，其中Q为氢或-SO2R1; X为键，O，S(O)n，-CH=CH-，-CH2CH2-，-CC-或-CH2S(O)nCH2-; R1为OH，NH2，C1到C6烷氧基，C1到C3全氟烷氧基; Ar为(a)或(b); Ar'为(c)或(d); R2和R4分别独立地为氢，OR6，-S(O)mR6，-NHR6，-N(R6)2或-CH2SO2CH3; R3和R5独立地为氢，-NO2，-NH2，-SO2R9或-CH2R9; R6为氢，C1到C6烷基，C3到C6烯基，-CH2CH2Z，-CH2COR7，-CH2CH=CHCOR7，(e)，(f)或(g); Y1和Y3独立地为N或CH; Y2和Y4独立地为O，S或NR13; R7为-OR8，-NHR8，-N(R8)2或-NHCH2CH2OR8; Z为-OR8，-OCH2CH2OR8，-N(R8)2或(h); R8为氢或C1到C3烷基; R9为C1到C6烷基，C3到C6烯基，OH，NHR10，N(R10)2，CH2COR11，-CH2CH=CHCOR11或(i); R10为C1到C3烷基，C3到C4烯基，苯基，-CH2CH2OCH3或-(j); R11为-OR12，-NHR12，-N(R12)2或-NHCH2CH2OR12; R12为氢或C1到C3烷基; R13为氢或C1到C3烷基; W为键，CH2，CH2CH2，O，S(O)q，NCHO，NCOCH3或NR12; m为0-2; n为0-2; q为0-2，但R2和R3不能同时为氢; 或其药学上可接受的盐，其作为避孕剂有用。
• Aryl sulfonic acids and derivatives as FSH antagonists
  申请人：American Home Products Corporation

  公开号：US20020111369A1

  公开（公告）日：2002-08-15

  This invention provides compounds of formula I having the structure 1 wherein Q is hydrogen or —SO 2 R 1 ; X is a bond, O, S(O) n , —CH═CH—, —CH 2 CH 2 —, —C≡C—, or —CH 2 S(O) n CH 2 —; R 1 is OH, NH 2 , C 1 to C 6 alkoxy, C 1 to C 3 perfluoroalkoxy; 2 R 2 and R 4 are each, independently, hydrogen, OR 6 , —S(O) m R 6 , —NHR 6 , —N(R 6 ) 2 , or —CH 2 SO 2 CH 3 ; R 3 and R 5 are each, independently, hydrogen, —NO 2 , —NH 2 , —SO 2 R 9 , or —CH 2 R 9 ; R 6 is hydrogen, C 1 to C 6 alkyl, C 3 to C 6 alkenyl, —CH 2 CH 2 Z, —CH 2 COR 7 , —CH 2 CH═CHCOR 7 3 Y 1 and Y 3 are each, independently, N, or CH; Y 2 and Y 4 are each independently, O, S, or NR 13 ; R 7 is —OR 8 , —NHR 8 , —N(R 8 ) 2 , or —NHCH 2 CH 2 OR 8 ; Z is —OR 8 , —OCH 2 CH 2 OR 8 , —N(R 8 ) 2 , or 4 R 8 is hydrogen, or C 1 to C 3 alkyl; R 9 is C 1 to C 6 alkyl, C 3 to C 6 alkenyl, OH, NHR 10 , N(R 10 ) 2 , CH 2 COR 11 , —CH 2 CH═CHCOR 11 , or 5 R 10 is C 1 to C 3 alkyl, C 3 to C 4 alkenyl, phenyl, —CH 2 CH 2 OCH 3 , or 6 R 11 is —OR 12 , NHR 12 , —N(R 12 ) 2 , or —NHCH 2 CH 2 OR 12 ; R 12 is hydrogen, or C 1 to C 3 alkyl; R 13 is hydrogen, or C 1 to C 3 alkyl; W is a bond, CH 2 , CH 2 CH 2 , O, S(O) q , NCHO, NCOCH 3 , or NR 12 ; m is 0-2; n is 0-2; q is 0-2, with the proviso that R 2 and R 3 are not both hydrogen; or pharmaceutically acceptable salt thereof, which are useful as contraceptive agents.

  本发明提供了式I的化合物，其具有结构1， 其中， Q为氢或—SO2R1； X为键合，O，S(O)n，—CH═CH—，—CH2CH2—，—C≡C—或—CH2S(O)nCH2—； R1为OH，NH2，C1到C6烷氧基，C1到C3全氟烷氧基； R2和R4各自独立地为氢，OR6，—S(O)mR6，—NHR6，—N(R6)2或—CH2SO2CH3； R3和R5各自独立地为氢，—NO2，—NH2，—SO2R9或—CH2R9； R6为氢，C1到C6烷基，C3到C6烯基，—CH2CH2Z，—CH2COR7，—CH2CH═CHCOR73； Y1和Y3各自独立地为N或CH； Y2和Y4各自独立地为O，S或NR13； R7为—OR8，—NHR8，—N(R8)2或—NHCH2CH2OR8； Z为—OR8，—OCH2CH2OR8，—N(R8)2或 4 R8为氢或C1到C3烷基； R9为C1到C6烷基，C3到C6烯基，OH，NHR10，N(R10)2，CH2COR11，—CH2CH═CHCOR11或 5 R10为C1到C3烷基，C3到C4烯基，苯基，—CH2CH2OCH3或 6 R11为—OR12，NHR12，—N(R12)2或—NHCH2CH2OR12； R12为氢或C1到C3烷基； R13为氢或C1到C3烷基； W为键合，CH2，CH2CH2，O，S(O)q，NCHO，NCOCH3或NR12； m为0-2； n为0-2； q为0-2； 但R2和R3不能同时为氢； 或其药学上可接受的盐，其作为避孕剂具有用途。
• PHOTOCROSSLINKABLE MATERIALS
  申请人：BACHELS Thomas

  公开号：US20120076952A1

  公开（公告）日：2012-03-29

  A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.

  提议一种化学式为（I）的二胺化合物，以及基于该化合物的聚合物、共聚物、聚酰胺酸、聚酰胺酸酯或聚酰亚胺。
• Photocrosslinkable materials
  申请人：Rolic AG

  公开号：EP2305631A1

  公开（公告）日：2011-04-06

  A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.

  提出了一种式 (I) 的二胺化合物，以及以这种化合物为基础的聚合物、共聚物、聚氨基 酸、聚氨基甲酸酯或聚酰亚胺。
• Photoalignment composition
  申请人：ROLIC AG

  公开号：US10558089B2

  公开（公告）日：2020-02-11

  The present invention relates to a photoalignment composition comprising a) 0.001 to 20%, by weight; preferably, 1 to 10% by weight, more preferably 1 to 9% by weight of at least one photoreactive compound (I) that comprises a photoalignment group and b) 80 to 99.999% by weight, preferably, 90 to 99% by weight, more preferably 91 to 99% by weight of at least one compound (II) that does not comprise a photoalignment group, and c) optionally at least one reactive or non reactive additives, and d) optionally at least one solvent. Further, the present invention relates to the use of this photoalignment composition for the alignment of liquid crystals or liquid crystal polymers, in electro-optical and optical elements, systems and devices.

  本发明涉及一种光配位组合物，该组合物包含 a) 至少一种包含光配位基团的光活性化合物(I)，其重量百分比为 0.001 至 20%；优选为 1 至 10%，更优选为 1 至 9%；以及 b) 至少一种不包含光配位基团的化合物(II)，其重量百分比为 80 至 99.999%(重量)，更优选90至99%(重量)，更优选91至99%(重量)的至少一种不包含光配位基团的化合物(II)，以及c)可选的至少一种活性或非活性添加剂，以及d)可选的至少一种溶剂。此外，本发明还涉及在电子光学和光学元件、系统和设备中将这种光配位组合物用于液晶或液晶聚合物的配位。