2,3,4,5-四甲基吡啶 | 18441-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,3,4,5-四甲基吡啶
• 英文名称: 2,3,4,5-tetramethyl pyridine
• 英文别名: 2,3,4,5-tetramethylpyridine；2,3,4,5-trimethylpyridine；tetramethylpyridine；2,3,4,5-tetramethyl-pyridine；2,3,4,5-Tetramethyl-pyridin；2,3,4,5-Tetramethylpyridin
• CAS: 18441-60-6
• 化学式: C₉H₁₃N
• 分子量: 135.209
• InChiKey: BKCIQPUIDHPJSI-UHFFFAOYSA-N

物化性质

• 保留指数：
  1220

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2,3,4,5-四甲基吡啶 在 potassium permanganate 作用下， 生成 pyridine-2,3,4,5-tetracarboxylic acid
  参考文献：
  名称：

  Ahrens, Chemische Berichte, 1895, vol. 28, p. 798

  摘要：

  DOI：
• 作为产物：
  描述：

  1-benzyl-3,4,5,6-tetramethyl-2-(trimethylsilyl)-1,2-dihydropyridine 在 palladium on activated charcoal air 、 氢气 作用下， 以 2,2,2-三氟乙醇 、 甲苯 为溶剂， 反应 28.0h， 以59 mg的产率得到2,3,4,5-四甲基吡啶
  参考文献：
  名称：

  Synthesis of Dihydropyridines and Pyridines from Imines and Alkynes via C−H Activation

  摘要：

  A convenient one-pot C-H alkenylation/electrocyclization/aromatization sequence has been developed for the synthesis of highly substituted pyridine derivatives from alkynes and alpha,beta-unsaturated N-benzyl aldimines and ketimines that proceeds through dihydropyridine intermediates. A new class of ligands for C-H activation was developed, providing broader scope for the alkenylation step than could be achieved with previously reported ligands. Substantial information was obtained about the mechanism of the reaction. This included the isolation of a C-H activated complex and its structure determination by X-ray analysis; in addition, kinetic simulations using the Copasi software were employed to determine rate constants for this transformation, implicating facile C-H oxidative addition and slow reductive elimination steps.

  DOI：

  10.1021/ja7104784

文献信息

• A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: a one-step synthesis of the monoterpene natural product, (−)-actinidine
  作者：Dilipkumar Uredi、Damoder Reddy Motati、E. Blake Watkins

  DOI：10.1039/c9cc01097a

  日期：——

  followed by concomitant cyclization through an allenyl intermediate to afford pyridines in excellent yields, with water as the sole by-product. This mild strategy is also suitable for functionalization of natural products or other advanced intermediates having α,β-unsaturated carbonyl functionality. The utility of the present protocol was showcased with the synthesis of the monoterpene alkaloid, (−)-actinidine

  已经开发了一种简单的模块化单步合成法，可从容易获得的α，β-不饱和羰基化合物和炔丙基胺合成各种取代的吡啶。本方案具有广泛的底物范围，并允许在温和且无金属的条件下通过选择性控制取代模式来接近多取代的吡啶。该反应涉及亚胺的形成，随后伴随通过烯基中间体的环化，以优异的收率得到吡啶，其中水是唯一的副产物。这种温和的策略也适用于天然产物或其他具有α，β-不饱和羰基官能团的高级中间体的官能化。本协议的效用通过单蚁生物碱（-）-in啶，一种与蚂蚁相关的虹彩样生物的合成得以展示。
• NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS
  申请人：Watkins Edmond Blake

  公开号：US20200095245A1

  公开（公告）日：2020-03-26

  The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

  本发明涉及取代吡啶的新的制备方法及其由此产生的化合物。特别是，本发明提供了一种高效的方法，用于构建不同取代的吡啶，具有不同的取代模式，在简单和无金属条件下具有高原子经济和锅经济以及优良的功能团耐受性，并且适用于天然产物的合成。
• Single component cationic palladium proinitiators for the latent polymerization of cycloolefins
  申请人：Bell Andrew

  公开号：US20050187398A1

  公开（公告）日：2005-08-25

  Palladium compound compositions are provided in accordance with Formulae [((R) 3 E) a Pd(Q)(LB) b ] p [WCA] r , where ((R) 3 E) is a Group 15 electron donor ligand, Q is an anionic ligand, LB is a Lewis base, WCA is a weakly coordinating anion, a is 1, 2 or 3, b is 0, 1 or 2, the sum of a and b is 1, 2 or 3 and each of p and r is an integer such that the molecular charge is zero, or [(E(R) 3 )(E(R) 2 R*)Pd(LB)] p [WCA] r where E(R) 2 R* represents a Group 15 neutral electron donor ligand and where R* is an anionic hydrocarbyl containing moiety, bonded to the Pd and having a β hydrogen with respect to the Pd center. Such compound composition exhibits latent polymerization activity in the presence of polycyclic olefins.

  钯化合物组成按照以下公式提供：[((R)3E)aPd(Q)(LB)b]p[WCA]r，其中((R)3E)是第15族电子供体配体，Q是阴离子配体，LB是路易斯碱，WCA是弱配位阴离子，a为1、2或3，b为0、1或2，a和b的总和为1、2或3，p和r各自为整数，使得分子电荷为零，或[(E(R)3)(E(R)2R*)Pd(LB)]p[WCA]r，其中E(R)2R*代表第15族中性电子供体配体，R*是与Pd键合的含有阴离子烃基的部分，并且相对于Pd中心具有β氢。这种化合物组成在多环烯烃存在时表现出潜在的聚合活性。
• [EN] ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND RADIATION<br/>[FR] CO-ADMINISTRATION D'UN INHIBITEUR D'ENZYME ACTIVANT L'UBIQUITINE ET DE RAYONS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2016069393A1

  公开（公告）日：2016-05-06

  Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient an ubiquitin-activating enzyme (UAE) inhibitor such as ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(3-(trifluoromethylthio) phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (Compound 1) or a pharmaceutically acceptable salt in combination with radiation. Also disclosed are medicaments for use in the treatment of cancer.

  揭示了治疗癌症的方法，适用于需要此类治疗的患者。这些方法包括向这样的患者施用泛素激活酶（UAE）抑制剂，如((1R,2R,3S,4R)-2,3-二羟基-4-(2-(3-(三氟甲基硫基)苯基)吡唑并[1,5-a]嘧啶-7-基氨基)环戊基)甲基磺酸酯（化合物1）或药学上可接受的盐与放射线结合使用。还披露了用于癌症治疗的药物。
• POLYMERIZATION INITIATOR, MODIFIED-CONJUGATED DIENE POLYMER AND TIRE PRODUCED THEREFROM
  申请人：LG CHEM, LTD.

  公开号：US20140163163A1

  公开（公告）日：2014-06-12

  The present disclosure relates to a polymerization initiator and a modified conjugated diene polymer prepared using the same, and more particularly to a polymerization initiator which is a compound represented by the following formula 1, and a modified conjugated diene polymer prepared using the same: wherein R 1 to R 5 are each independently hydrogen or a C 1-10 alkylgroup or its carbanion; n− represents the number of negative charges of the carbanion and is 1− to 5−; M is a metal; and n is equal to the number of carbanions in R 1 to R 5 .

  本公开涉及一种聚合引发剂以及使用该聚合引发剂制备的改性共轭二烯聚合物，更具体地说，是一种由以下公式1所示的化合物组成的聚合引发剂，以及使用其制备的改性共轭二烯聚合物： 其中R1至R5各自独立地为氢或C1-10烷基或其碳负离子；n-代表碳负离子的负电荷数，为1-至5-；M是一种金属；n等于R1至R5中碳负离子的数量。