2,3,4,6-四乙基-1,4-吡嗪 | 38325-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2,3,4,6-四乙基-1,4-吡嗪
• 英文名称: 2,3,5,6-tetraethylpyrazine
• 英文别名: Tetraethylpyrazin；2,3,5,6-Tetraaaethylpyrazin；tetraethyl-pyrazine；Tetraethylpyrazine
• CAS: 38325-19-8
• 化学式: C₁₂H₂₀N₂
• mdl: MFCD03265294
• 分子量: 192.304
• InChiKey: OEDVLMOQTFMJCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  丙腈 在 四氯化钛 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 144.0h， 以63%的产率得到2,3,4,6-四乙基-1,4-吡嗪
  参考文献：
  名称：

  Low-Valent Titanium Induced Reductive Cyclization of Nitriles to Symmetrically Substituted Tetraalkylpyrazines

  摘要：

  四氯化钛/锌诱导的氰基1的还原环化作用，为对称取代的四烷基吡嗪2提供了一种高效通用的合成方法。

  DOI：

  10.1055/s-1990-26987

文献信息

• A polyheterocyclic compound, its preparation and a smoking composition in which it is used
  申请人：PHILIP MORRIS INCORPORATED

  公开号：EP0021663A1

  公开（公告）日：1981-01-07

  he invention provides a smoking composition containing a flavourant additive comprising a polyheterocyclic compound corresponding to the formula: wherein R is hydrogen or an alkyl group X is a pyrazyl or alkyl-substituted pyrazyl ring containing a total of 4 to 16 carbon atoms, X' is a pyrazyl, alkyl-substituted pyrazyl, pyridyl or alkyl-substituted pyridyl ring containing a total of 4 to 22 carbon atoms; each alkyl group or substituent having 1 to 10 carbon atoms, and any adjacent R and X or any adjacent R and X1when taken together with connecting elements form an alicyclic structure. The preferred flavourants are novel compounds having the formula wherein R'and R2 are hydrogen or methyl orethyl groups and Y is a pyrazine or pyridine radical corresDondina to the structures: and any adjacent R1 and R2when taken together with connecting elements form an alicyclic structure. Under smoking conditions such polyheterocyclic compounds flavour mainstream and sidestream smoke. Additionally such compounds will flavour foodstuffs when incorporated therein orwhen the foodstuff, for example meat, is contacted with gases produced by combustion of a material containing the compounds. The polyheterocyclic compounds will also enhance the aroma of burning combustible articles such as candles or solid fuel.

  本发明提供了一种含香料添加剂的烟用组合物，该香料添加剂由与式相应的多杂环化合物组成： 其中 R 是氢或烷基 X 是吡嗪基或烷基取代的吡嗪基环，共含有 4 至 16 个碳原子，X'是吡嗪基、烷基取代的吡嗪基、吡啶基或烷基取代的吡啶基环，共含有 4 至 22 个碳原子；每个烷基或取代基具有 1 至 10 个碳原子，任何相邻的 R 和 X 或任何相邻的 R 和 X1 与连接元素一起形成脂环结构。首选的调味剂是具有以下式子的新型化合物 其中，R'和 R2 是氢或甲基奥氏基，Y 是吡嗪或吡啶基，与上述结构相关： 任何相邻的 R1 和 R2 与连接元素一起形成脂环结构。在吸烟条件下，此类多杂环化合物可为主流和侧流烟雾增添风味。此外，当食品中含有此类化合物时，或当食品（如肉类）与含有此类化合物的材料燃烧产生的气体接触时，此类化合物也会为食品增添风味。多环化合物还能增强蜡烛或固体燃料等可燃物品燃烧时的香味。
• Flavorant-release additives and compositions containing them
  申请人：Philip Morris Products Inc.

  公开号：EP0309203A2

  公开（公告）日：1989-03-29

  This invention provides smoking compositions which contain a novel heteroaromatic flavorant-release additive as illustrated by the following structure: where R is hydrogen or a C₁-C₄ alkyl group; R¹ is hydrogen or a C₁-C₈ alkyl group; and R² is a C₃-C₁₂ aromatic substituent; with the proviso that at least two R¹ groups are C₁-C₈ alkyl radicals. Under typical cigarette smoking conditions, 2-isopropylpyrazine and acetophenone are released as pyrolysis products, and enhance the flavor and aroma of the mainstream and sidestream smoke.

  本发明提供了含有新型杂芳香族香料释放添加剂的烟用组合物，其结构如下： 其中 R 是氢或 C₁-C₄ 烷基；R¹ 是氢或 C₁-C₈ 烷基；R² 是 C₃-C₁₂ 芳族取代基；但至少有两个 R¹ 基团是 C₁-C₈ 烷基。 在典型的香烟吸食条件下，2-异丙基吡嗪和苯乙酮会作为热分解产物释放出来，并增强主流烟和副流烟的味道和香气。
• Ethylation of Pyrazines Using Alkylmetals, Such as Triethylaluminum, Diethylzinc, and Triethylborane
  作者：Akihiro Ohta、Masakatsu Ohta、Yohsiaki Igarashi、Kaemi Saeki、Kayo Yuasa、Tomoko Mori

  DOI：10.3987/r-1987-09-2449

  日期：——
• CHEN, WEI-XING;ZHANG, JUN-HU;HU, MING-YANG;WANG, XIAO-CHUN, SYNTHESIS,(1990) N, C. 701-702
  作者：CHEN, WEI-XING、ZHANG, JUN-HU、HU, MING-YANG、WANG, XIAO-CHUN

  DOI：——

  日期：——
• Cp2TiCl2-catalyzed synthesis of tetraalkyl-substituted pyrazines by the reaction of nitriles with EtAlCl2 and Mg
  作者：Mariya G. Shaibakova、Nikita A. Rikhter、Leisan K. Dil'mukhametova、Ilfir R. Ramazanov

  DOI：10.1016/j.mencom.2023.02.031

  日期：2023.3