2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-6-醇 | 23778-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-6-醇
• 中文别名: 乙酸,2-(4-乙酰基-2-甲基苯氧基)-,甲基酯
• 英文名称: 6-Hydroxytetrahydronorharmane
• 英文别名: 1,2,3,4-tetrahydro-6-hydroxy-β-carboline；6-hydroxy-1,2,3,4-tetrahydro-β-carboline；2,3,4,9-tetrahydro-1H-β-carbolin-6-ol；6-hydroxy-2,3,4,9-tetrahydro-1H-β-carboline；6-hydroxy-THBC；5-Hydroxytryptoline；2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-6-ol
• CAS: 23778-34-9
• 化学式: C₁₁H₁₂N₂O
• mdl: MFCD01690291
• 分子量: 188.229
• InChiKey: HASNCBJLQYTILW-UHFFFAOYSA-N

物化性质

• 熔点：
  294°C

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  48
• 氢给体数：
  3
• 氢受体数：
  2

ADMET

代谢

1H,2H,3H,4H,9H-吡啶[3,4]吲哚-6-醇是松脂酚的一个已知人体代谢物。

1H,2H,3H,4H,9H-pyrido[3,4]indol-6-ol is a known human metabolite of pinoline.

来源:NORMAN Suspect List Exchange

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  1-Carboxy-6-hydroxy-1,2,3,4-tetrahydro-2-carbolin 生成 2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-6-醇
  参考文献：
  名称：

  YAMANO, TOSHIO;MIURA, RETSU;KANASHIRO, MASARKU;UEMURA, TOMIHIKO, BIOORG. CHEM., 16,(1988) N 2, 189-205

  摘要：

  DOI：

文献信息

• The Chemistry of Indoles. CVII. A Novel Synthesis of 3,4,5,6-Tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indoles and a New Finding on Pictet-Spengler Reaction.
  作者：Masanori SOMEI、Sakiko TERANISHI、Koji YAMADA、Fumio YAMADA

  DOI：10.1248/cpb.49.1159

  日期：——

  4,5,6-tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indoles by simple heating with amines under an oxygen atmosphere. Serotonins also reacted with various aldehydes to provide 3,4,5,6-tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indoles rather than beta-carbolines under basic conditions. In these novel reactions, the presence of the 5-hydroxy group on the indole nucleus was suggested to be essential. Possible

  发现5-羟色胺通过在氧气气氛下简单地与胺加热而产生3,4,5,6-四氢-7-羟基-1H-氮杂环庚烷[5,4,3-cd]吲哚。在碱性条件下，5-羟色胺还与各种醛反应生成3,4,5,6-四氢-7-羟基-1H-氮杂环庚烷[5,4,3-cd]吲哚而不是β-咔啉。在这些新颖的反应中，吲哚核上5-羟基的存在被认为是必不可少的。讨论了可能的机制。
• 2-(aminomethyl) arylamide analgesics
  申请人：PHARMACOPEIA, INC

  公开号：US20040167119A1

  公开（公告）日：2004-08-26

  A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the formula I: 1 A representative example is: 2

  本发明揭示了一种2-(氨甲基)芳基酰胺的化学类，其作为镇痛剂具有用途。该类别由公式I表示：1。代表性的例子为：2。
• Indazole compound and pharmaceutical use thereof
  申请人：Takemiya Akihiro

  公开号：US20070173537A1

  公开（公告）日：2007-07-26

  The present invention can provide a cancer treatment drug containing, as an active ingredient, a substance selected from the group consisting of an indazole compound of the following formula (I), a pharmaceutically acceptable salt, a hydrate, a water adduct and a solvate:

  本发明可以提供一种癌症治疗药物，其包含以下公式（I）中的吲唑化合物、药用可接受盐、水合物、水加合物和溶剂化物等物质中所选的一种作为活性成分：
• Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
  申请人：ALZA CORPORATION

  公开号：EP0331391A1

  公开（公告）日：1989-09-06

  A method and means for reducing sensitization or irritation caused by transdermally delivered drugs, wherein one or more metabolic modulators is coadministered with a sensitizing or irritating drug.

  一种减少透皮给药引起的致敏或刺激的方法和手段，其中一种或多种代谢调节剂与致敏或刺激药物同时给药。
• Methods for preventing pressure-induced apoptotic neural-cell death
  申请人：Coroneo Theodore Minas

  公开号：US20060013814A1

  公开（公告）日：2006-01-19

  Compositions and methods for protecting neuronal cells from pressure-induced apoptotic cell death which comprises administering to a subject in need of such treatment at least one compound which directly or indirectly inhibits the activity of an ion channel on neuronal cells and thereby inhibits the effect of pressure on the cells.

  保护神经细胞免受压力诱导的细胞凋亡的组合物和方法，其中包括向需要此类治疗的受试者施用至少一种化合物，该化合物可直接或间接抑制神经细胞上离子通道的活性，从而抑制压力对细胞的影响。