2,3-二羟基丙基水杨酸酯 | 6170-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3-二羟基丙基水杨酸酯
• 中文别名: 2-羟基苯甲酸2,3-二羟基丙酯；2,3-二羟基丙基2-羟基苯甲酸酯；2-羟基苯甲酸甘油基酯
• 英文名称: 2-Hydroxy-benzoesaeure-<2,3-dihydroxy-propylester>
• 英文别名: 2-hydroxy-benzoic acid 2,3-dihydroxy-propyl ester；salicylic acid-(2,3-dihydroxy-propyl ester)；Salicylsaeure-(2,3-dihydroxy-propylester)；(+/-)-1-Salicyloyloxy-propandiol-(2.3)；glycerin-salicylic acid；Glycerinmonosalicylat；Monosalicylin；2,3-Dihydroxypropyl salicylate；2,3-dihydroxypropyl 2-hydroxybenzoate
• CAS: 6170-45-2
• 化学式: C₁₀H₁₂O₅
• 分子量: 212.202
• InChiKey: OGFSIPREEZAEMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2918230000

反应信息

• 作为反应物：
  描述：

  2,3-二羟基丙基水杨酸酯 、 苯硼酸 生成 2-hydroxy-benzoic acid 2-phenyl-[1,3,2]dioxaborolan-4-ylmethyl ester
  参考文献：
  名称：

  Serafinowa,B.; Milkowska,G., Roczniki Chemii, 1964, vol. 38, p. 897 - 898

  摘要：

  DOI：
• 作为产物：
  描述：

  甘油 、 水杨酸甲酯 在 氢氧化钾 作用下， 以62%的产率得到2,3-二羟基丙基水杨酸酯
  参考文献：
  名称：

  Synthesis of α-monoglycerides of aromatic acids

  摘要：

  The synthesis of alpha-monoglycerides of aromatic acids has been performed by the transesterification of the methyl esters of the corresponding acids with glycerol. The structures of the compounds obtained have been confirmed by their IR, UV, and H-1 and C-13 NMR spectra.

  DOI：

  10.1007/bf02282504

文献信息

• Allantoin-containing preparations for administration as gels and aerosols
  申请人：Alwyn Company, Inc.

  公开号：US20030147968A1

  公开（公告）日：2003-08-07

  Allantoin-containing preparations are prepared in a form suitable for administration as gels and aerosols. In one embodiment of the aerosol formulation, an allantoin-containing composition comprises: (1) water; (2) allantoin in a therapeutically effective quantity; (3) an anionic ethoxylated surfactant; (4) lanolin oil; and (5) cod liver oil. The composition has a viscosity and surface tension in a range that allows the composition to be administered to the skin of a user as an aerosol by a mechanical spray pump. In another aspect of this invention, the allantoin-containing preparations are prepared in a form suitable for administration as gels. The compositions can be substantially anhydrous or can contain water. In one embodiment of the gel formation, an allantoin-containing composition comprises: (1) allantoin in a therapeutically effective quantity; (2) a complex comprising mineral oil and at least one hydrogenated alkylene copolymer; (3) lanolin oil; and (4) cod liver oil. The compositions can comprise other ingredients. Compositions according to the present invention are suitable for the treatment of a number of skin conditions or diseases characterized by ulceration, inflammation, or blistering of the skin, such as epidermolysis bullosa.

  含有尿囊素的制剂以适合作为凝胶和气雾剂的形式制备。在气雾剂配方的一个实施例中，含有尿囊素的组合物包括：（1）水；（2）疗效有效量的尿囊素；（3）阴离子乙氧基化表面活性剂；（4）羊毛脂油；和（5）鱼肝油。该组合物具有粘度和表面张力范围，使得通过机械喷雾泵将组合物作为气雾施用到用户皮肤上。在这项发明的另一个方面，含有尿囊素的制剂以适合作为凝胶的形式制备。这些组合物可以是几乎无水的，也可以含水。在凝胶形成的一个实施例中，含有尿囊素的组合物包括：（1）疗效有效量的尿囊素；（2）包括矿物油和至少一种氢化烷烯共聚物的复合物；（3）羊毛脂油；和（4）鱼肝油。这些组合物可以包含其他成分。根据本发明的组合物适用于治疗一系列皮肤状况或疾病，其特征是皮肤溃疡、炎症或水疱，如表皮溶解性水疱症。
• Dual-cure cement
  申请人：Imperial Chemical Industries Plc

  公开号：US04886843A1

  公开（公告）日：1989-12-12

  The compositions of this invention posses both calcium hydroxide cement characteristics and light cure characteristics and hence strong bonds are likely to form with both the tooth and conventional filling materials. There is less likelihood that a filling may fall out of a cavity. The present invention provides a two component composition which comprises a first component comprising an ethylenically polymerizable compound which contains both a salicylate group and at least one acrylate, alkacrylate, acrylamide or alkacrylamide group and second component comprising calcium hydroxide or a suitable precursor to calcium hydroxide.

  本发明的组合物具有钙氢氧化物水泥特性和光固化特性，因此可能与牙齿和传统填充材料形成牢固的粘结。填充物脱落的可能性较小。本发明提供了一种双组分组合物，包括第一组分，其中包含既含有水杨酸盐基团又含有至少一个丙烯酸酯、烷基丙烯酸酯、丙烯酰胺或烷基丙烯酰胺基团的乙烯基可聚合化合物，以及第二组分，包括氢氧化钙或适合制备氢氧化钙的前体。
• ZINC OXIDE COMPLEXES
  申请人：Swanzy James

  公开号：US20120130091A1

  公开（公告）日：2012-05-24

  Disclosed are compounds comprising a zinc oxide molecule chemically bound to one or more molecules having an acidic hydrogen, such as an organic acid. The invention also provides compositions comprising such compounds and methods of preparing such compounds. The compounds of the invention may be provided in, for example, topical skin formulations, pharmaceutical compositions, or delivery systems for active ingredients.

  本发明揭示了一种化学上与一个或多个具有酸性氢原子的分子（例如有机酸）结合的氧化锌分子的化合物。本发明还提供了包含这种化合物的组合物以及制备这种化合物的方法。本发明的化合物可以用于例如局部皮肤制剂、药物组合物或活性成分的输送系统中。
• SOLUBILIZING AGENT AND EXTERNAL PREPARATION CONTAINING THE SAME
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0698393A1

  公开（公告）日：1996-02-28

  A solubilizing agent for an active ingredient which comprises 3-l-menthoxypropane-1,2-diol and an external preparation containing said solubilizing agent and an active ingredient.

  一种由 3-l-menthoxypropane-1,2-diol 组成的活性成分增溶剂，以及一种含有上述增溶剂和活性成分的外用制剂。
• REFRIGERANT COMPOSITIONS, REFRIGERANT AUXILIARY COMPOSITIONS AND USES THEREOF
  申请人：Takasago International Corporation

  公开号：EP1496095A1

  公开（公告）日：2005-01-12

  The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-1-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N,2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

  本发明的清凉感组合物通过将含有至少一种选自 1-薄荷醇、异薄荷醇、3-(1-薄荷氧基)丙烷-1,2-二醇、2-(1-薄荷氧基)乙烷-1-醇、3-(1-薄荷氧基)丙烷-1-醇、2-甲基-3-(1-薄荷氧基)丙烷-1,2-二醇、N-乙基-1-薄荷甲酰胺、对薄荷-3,8-二醇、1-薄荷乳酸酯和 2-异丙基-N,2,3-三甲基丁酰胺的化合物的清凉感物质与下述通式(I)代表的水杨酸酯（如水杨酸 2-羟乙基酯）结合而获得，可改善清凉感、和 2-异丙基-N,2,3-三甲基丁酰胺与以下通式（I）代表的水杨酸酯（如水杨酸 2-羟乙基酯）混合，可提高清凉感的强度和持久性，特别是含有 1-薄荷醇作为清凉感物质的清凉感组合物，可减轻 1-薄荷醇产生的刺激性香味。将清凉感组合物或含有清凉感组合物的香料组合物与食品和饮料、化妆品、盥洗用品、沐浴剂和药品等产品混合，可以得到有效发挥本发明清凉感组合物上述特点的产品。 其中 R 代表具有 1 至 18 个碳原子的烃基，该烃基可能具有取代基。