2,4,5,6,7-五甲基-1H-苯并咪唑 | 69700-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 2,4,5,6,7-五甲基-1H-苯并咪唑
• 英文名称: 2,4,5,6,7-pentamethyl-1H-benzimidazole
• 英文别名: 2,4,5,6,7-Pentamethyl-1H-benzimidazol；2,4,5,6,7-pentamethyl-1H-benzimidazole
• CAS: 69700-34-1
• 化学式: C₁₂H₁₆N₂
• mdl: MFCD00119565
• 分子量: 188.272
• InChiKey: IISNIICZFRRUGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4,5,6,7-五甲基-1H-苯并咪唑 在 苯甲醛 作用下， 生成 4,5,6,7-tetramethyl-2-trans-styryl-1H-benzimidazole
  参考文献：
  名称：

  Studies on the Polymethylbenzenes. XI. The Nitration of Pentamethylbenzene and of Hexamethyl- and Hexaethylbenzene^1,2

  摘要：

  DOI：

  10.1021/ja01310a035
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 tin 作用下， 生成 2,4,5,6,7-五甲基-1H-苯并咪唑
  参考文献：
  名称：

  Toehl, Chemische Berichte, 1888, vol. 21, p. 906

  摘要：

  DOI：

文献信息

• Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
  申请人：Anikin Alexey Vyacheslavovich

  公开号：US20080207635A1

  公开（公告）日：2008-08-28

  The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.

  本发明提供了能够调节酪氨酸激酶的化合物，包括这些化合物的组合物和使用它们的方法。
• Benzimidazole derivatives and their use as kdr kinase protein inhibitors
  申请人：Babin Didier

  公开号：US20080125418A1

  公开（公告）日：2008-05-29

  The invention discloses and claims benzimidazole compounds of formula (I): wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl or a saturated 5- or 6-membered monocyclic heterocyclic radical or a bicyclic heterocyclic radical; and A5 is H or alkyl; or a stereoisomer, a racemate, an enantiomer or a diastereoisomer of said compound of formula (I) or a pharmaceutically acceptable salt thereof; the use of compounds of formula (I) for the treatment of a disorder of proliferation of blood vessels, uncontrolled angiogenesis, a fibrotic disorder, a disorder of proliferation of mesangial cells, a metabolic disorder, allergy, asthma, thrombosis, a disease of the nervous system, retinopathy, psoriasis, rheumatoid arthritis, diabetes, muscle degeneration, solid tumors and cancers, pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents and pharmaceutical compositions comprising a compound of formula (I) and one or more. antimitotic agents.

  本发明揭示和声明了式（I）的苯并咪唑化合物：其中X是C-R2; Y是C-R2或C-R3; W和Z均为C-R3; R1是可选择取代的芳基，杂芳基或饱和的5-或6-成员单环杂环基或双环杂环基; A5是H或烷基; 或者是式（I）的立体异构体，外消旋体，对映异构体或二对映异构体或其药学上可接受的盐; 本发明还涉及使用式（I）的化合物治疗血管增殖障碍，无控制的血管生成，纤维化障碍，系膜细胞增殖障碍，代谢障碍，过敏，哮喘，血栓形成，神经系统疾病，视网膜病变，牛皮癣，类风湿性关节炎，糖尿病，肌肉退化，实体瘤和癌症的药物组合物，包括式（I）的化合物和一个或多个药学上可接受的辅料或稀释剂以及包括式（I）的化合物和一个或多个抗有丝分裂剂的药物组合物。
• Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
  作者：Katarzyna Kopańska (née Zastąpiło)、Andżelika Najda、Justyna Żebrowska、Lidia Chomicz、Janusz Piekarczyk、Przemysław Myjak、Maria Bretner

  DOI：10.1016/j.bmc.2004.03.022

  日期：2004.5

  Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine. (C) 2004 Elsevier Ltd. All rights reserved.
• ELECTRODE COVERING MATERIAL, ELECTRODE STRUCTURE AND SEMICONDUCTOR DEVICE
  申请人：Murata Masaki

  公开号：US20100314611A1

  公开（公告）日：2010-12-16

  A semiconductor device is provided and includes a field effect transistor having a gate electrode, a gate insulating layer, a channel forming region composed of an organic semiconductor material layer and a source/drain electrode made of a metal. A portion of the source/drain electrode in contact with the organic semiconductor material layer comprising the channel forming region is covered with an electrode coating material. Because the electrode coating material is composed of organic molecules having a functional group which can be bound to a metal ion and a functional group that binds to the source/drain electrode composed of the metal, low contact resistance and high mobility can be achieved.
• POLYMERIC CONJUGATES OF AROMATIC AMINE CONTAINING COMPOUNDS INCLUDING RELEASABLE UREA LINKER
  申请人：Zhao Hong

  公开号：US20120289571A1

  公开（公告）日：2012-11-15

  The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.