2,4-二氯-6-(4-甲基哌嗪-1-基)嘧啶 | 1080622-72-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2,4-二氯-6-(4-甲基哌嗪-1-基)嘧啶
• 英文名称: 2, 4-dichloro-6-(4-methylpiperazin-1-yl)pyrimidine
• 英文别名: 2,4-Dichloro-6-(4-methyl-piperazin-1-yl)-pyrimidine；2,4-dichloro-6-(4-methylpiperazin-1-yl)pyrimidine
• CAS: 1080622-72-5
• 化学式: C₉H₁₂Cl₂N₄
• 分子量: 247.127
• InChiKey: WMLOWDFRQIVNAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-二氯-6-(4-甲基哌嗪-1-基)嘧啶 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium phosphate 、 palladium diacetate 、 铁粉 、 氯化铵 、 caesium carbonate 、 三乙胺 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 N-[4-[(E)-2-(4-[[5-(methoxymethyl)-1-(oxan-2-yl)pyrazol-3-yl]amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)ethenyl]phenyl]prop-2-enamide
  参考文献：
  名称：

  Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3

  摘要：

  DOI：

  10.1021/acsmedchemlett.0c00517
• 作为产物：
  描述：

  N-甲基哌嗪 、 2,4,6-三氯嘧啶 以 乙醇 为溶剂， 生成 2,4-二氯-6-(4-甲基哌嗪-1-基)嘧啶
  参考文献：
  名称：

  Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors

  摘要：

  Thiazol-2-yl amine was identified as an isosteric replacement for pyrazol-3-yl amine during our efforts to identify potent and selective JAK2 inhibitors. The rationale, synthesis and biological evaluation of several analogs is reported, along with the in vivo evaluation of the lead compounds. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.091

文献信息

• Novel pyrimidine derivatives
  申请人：Chemilia AB

  公开号：EP2502924A1

  公开（公告）日：2012-09-26

  The invention provides novel pyrimidine derivatives of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such compounds in treatment of diseases including cancer; wherein R1-R11, Z, and Y are as defined in the specification.

  该发明提供了式I的新型嘧啶衍生物，以及制备此类化合物的方法，含有这类化合物的药物组合物，以及利用这类化合物治疗包括癌症在内的疾病的方法；其中R1-R11，Z和Y如规范中所定义。
• [EN] NOVEL PYRIMIDINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIMIDINE
  申请人：CHEMILIA AB

  公开号：WO2012127032A1

  公开（公告）日：2012-09-27

  The invention provides novel pyrimidine derivatives of formula (I), methods of preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer; wherein R1-R11, Z, and Y are as defined in the specification.

  该发明提供了式（I）的新型嘧啶衍生物，以及制备这种化合物的方法、含有这种化合物的药物组合物，以及在治疗包括癌症在内的疾病中使用这种化合物的方法；其中R1-R11、Z和Y如规范中定义。
• Biaryl piperazinyl-pyridine analogues
  申请人：Bakthavatchalam Rajagopal

  公开号：US20070027155A1

  公开（公告）日：2007-02-01

  Biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式为：其中变量如此处所述的Biaryl piperazinyl-pyridine类似物。这些化合物是配体，可用于调节体内或体外特定受体活性，并且在治疗与人类、家养伴侣动物和家畜动物的病理性受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的这些配体的方法。
• AMINO-THIAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
  申请人：Almeida Lynsie

  公开号：US20100204231A1

  公开（公告）日：2010-08-12

  The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.

  本发明涉及式(I)的化合物及其制药组合物和使用方法。这些化合物提供了治疗骨髓增生性疾病和癌症的治疗方法。
• SUBSTITUTED BIARYL PIPERAZINYL-PYRIDINE ANALOGUES
  申请人：Blum Charles A.

  公开号：US20110003813A1

  公开（公告）日：2011-01-06

  Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了替代的联苯基哌嗪基吡啶类似物，其化学式为：其中变量如本文所述。此类化合物是配体，可用于体内或体外调节特定受体活性，并且在治疗与人类、驯养的伴侣动物和家畜动物的病理性受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的配体使用方法。