2,4-二溴-6-苯基苯酚 | 55815-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二溴-6-苯基苯酚
• 英文名称: 3,5-dibromo-2-hydroxybiphenyl
• 英文别名: 4,6-dibromo-2-phenylphenol；3,5-dibromobiphenyl-2-ol；3,5-dibromo-biphenyl-2-ol；3.5-Dibrom-2-hydroxy-biphenyl；4.6-Dibrom-2-phenyl-phenol；3,5-Dibrom-biphenyl-2-ol；2,4-Dibromo-6-phenylphenol
• CAS: 55815-20-8
• 化学式: C₁₂H₈Br₂O
• 分子量: 328.003
• InChiKey: FLAJYIKIPQZYAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为反应物：
  描述：

  2,4-二溴-6-苯基苯酚 在 硝酸 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 以470 mg的产率得到2,4-二硝基-6-苯基苯酚
  参考文献：
  名称：

  Hartshorn, Michael P.; Robinson, Ward T.; Vaughan, John, Australian Journal of Chemistry, 1985, vol. 38, # 4, p. 575 - 585

  摘要：

  DOI：
• 作为产物：
  描述：

  邻苯基苯酚 在 溴 、 溶剂黄146 作用下， 反应 2.0h， 生成 2,4-二溴-6-苯基苯酚
  参考文献：
  名称：

  Nitro-Substituted Hoveyda−Grubbs Ruthenium Carbenes:  Enhancement of Catalyst Activity through Electronic Activation

  摘要：

  The design, synthesis, stability, and catalytic activity of nitro-substituted Hoveyda-Grubbs metathesis catalysts are described. The highly active and stable meta- and para-substituted complexes are attractive from a practical point of view. These catalysts operate in very mild conditions and can be successfully applied in various types of metathesis [ring-closing metathesis, cross-metathesis (CM), and enyne metathesis]. Although the presence of a NO2 group leads to catalysts that are dramatically more active than both the second-generation Grubbs's catalyst and the phosphine-free Hoveyda's carbene, enhancement of reactivity is somewhat lower than that observed for a sterically activated Hoveyda-Grubbs catalyst. Attempts to combine two modes of activation, steric and electronic, result in severely decreasing a catalyst's stability. The present findings illustrate that different Ru catalysts turned out to be optimal for different applications. Whereas phosphine-free carbenes are catalysts of choice for CM of various electron-deficient substrates, they exhibit lower reactivity in the formation of tetrasubstituted double bonds. This demonstrates that no single catalyst outperforms all others in all possible applications.

  DOI：

  10.1021/ja048794v

文献信息

• Regioselective Aromatic Perfluoro-<i>tert</i>-butylation Using Perfluoro-<i>tert</i>-butyl Phenyl Sulfone and Arynes
  作者：Zhiqiang Wei、Lixian Wen、Kaidi Zhu、Qian Wang、Yanchuan Zhao、Jinbo Hu

  DOI：10.1021/jacs.2c10479

  日期：2022.12.7

  synthetic protocol to realize aromatic perfluoro-tert-butylation. The key to the success is the identification of PFtB phenyl sulfone as a new source of PFtB anion, which reacts with arynes in a highly regioselective manner to afford perfluoro-tert-butylated arenes in high yields. The application of the method is demonstrated by the preparation of sensitive 19F-labeled NMR probes with an extraordinary resolving

  长期以来，人们一直在寻求将全氟叔丁基（PFtB，CF 3基团的较大类似物）选择性引入芳烃中，但仍然是一项艰巨的任务。我们在此报告了第一个实现芳香族全氟叔丁基化的通用合成方案。成功的关键是将 PFtB 苯基砜鉴定为 PFtB 阴离子的新来源，它以高度区域选择性的方式与芳烃反应，以高产率提供全氟叔丁基芳烃。该方法的应用通过制备具有非凡分辨能力的灵敏的19 F-标记的NMR探针来证明。
• v. Auwers; Wittig, Journal fur praktische Chemie (Leipzig 1954), 1924, vol. <2> 108, p. 103
  作者：v. Auwers、Wittig

  DOI：——

  日期：——
• Halogenated hydroxydiphenyl
  申请人：SQUIBB &

  公开号：US01989081A1

  公开（公告）日：1935-01-29
• The Bromination of 2-Phenylphenyl Acetate
  作者：Stewart E. Hazlet、Harry A. Kornberg

  DOI：10.1021/ja01852a025

  日期：1941.7
• HARTSHORN, M. P.;ROBINSON, W. T.;VAUGHAN, J.;WHITE, J. M., AUSTRAL. J. CHEM., 1985, 38, N 4, 575-585
  作者：HARTSHORN, M. P.、ROBINSON, W. T.、VAUGHAN, J.、WHITE, J. M.

  DOI：——

  日期：——

表征谱图