阔叶黄檀酚 | 10154-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 阔叶黄檀酚
• 英文名称: latifolin
• 英文别名: R(-)-latifolin；5-[(1R)-1-(2-hydroxyphenyl)prop-2-enyl]-2,4-dimethoxyphenol
• CAS: 10154-42-4
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.328
• InChiKey: OJVQOGDGFIJYPN-LLVKDONJSA-N

物化性质

• 熔点：
  122-123 °C
• 沸点：
  485.8±45.0 °C(Predicted)
• 密度：
  1.232 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  阔叶黄檀酚 在 Lindlar's catalyst 氢气 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 (+/-)-1-<2-Methoxy-phenyl>-1-<2,4,5-trimethoxy-phenyl>-propan
  参考文献：
  名称：

  宪法Ø二甲基latifolin

  摘要：

  Dalbergia latifolia心材的轻质石油提取物，生成无色结晶固体latifolin，它是具有类似于dalbergin的C 15骨架的二羟基二甲基化合物。二甲醚的组成显示为γ，γ-（2,2'，4,5-四甲氧基）-二苯基丙烯（II）。

  DOI：

  10.1016/s0040-4020(01)99307-x

文献信息

• Bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders
  申请人：Maurya Rakesh

  公开号：US10292994B2

  公开（公告）日：2019-05-21

  The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, from Dalbergia sissoo plant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

  本发明涉及用于预防或治疗骨健康相关疾病的 Dalbergia sissoo 的生物活性馏分和化合物。本发明涉及药物组合物领域，提供了新的植物提取物、其馏分和从天然来源分离的纯化合物，这些提取物、馏分和纯化合物可用于预防和/或治疗与雌激素依赖性或独立疾病或综合症或紊乱有关的各种医学指征，优选用于预防或治疗人类和动物引起的雌激素依赖性或独立疾病或综合症或紊乱，以及在人类和动物骨骼生长和健康过程中达到峰值骨量。特别是本发明进一步涉及从豆科植物Dalbergia sissoo中制备生物活性提取物、馏分和分离纯化合物的工艺，它们是本发明主要方面的药学上可接受的盐和组合物。
• Bioactivity of Latifolin and Its Derivatives against Termites and Fungi
  作者：Nobuhiro Sekine、Tatsuya Ashitani、Tetsuya Murayama、Sakae Shibutani、Satoshi Hattori、Koetsu Takahashi

  DOI：10.1021/jf900719p

  日期：2009.7.8

  Latifolin (1) and its derivatives were investigated with the aim of confirming the correlation between bioactivity (antitermite and antifungal activity) and chemical structure. Termite mortality in response to the derivatives 2'-O-methyllatifolin (2), latifolin dimethyl ether (4), and latifolin diacetate (5) increased 2-fold compared to compound 1. The mortality rate from 5-O-methyllatifolin (3) was not different from 1. The mass loss (feed consumption by termite) in response to compounds 3-5 was 3 times greater than compound 1, and the mass loss from compound 2 was twice as great as compound 1. The mortality rate from compounds 4 and 5 increased sharply 7 days after initial exposure. In assessing the antifungal activity of these compounds, it was found that the inhibition rates of white- and brown-rot fungi in response to all derivatives were less than that for compound 1. Our findings indicate that the phenolic hydroxyl group at C-5 of the A ring provides antitermite activities (mortality and mass loss). In addition, both C-5 and C-2' phenolic hydroxyl groups in the A and B rings have antifungal activity against white- and brown-rot fungi. In conclusion, the bioactivity of compound 1 depends upon the position of phenolic hydroxyl groups,
• Constitution of latifolin
  作者：Darshan Kumari、S.K. Mukerjee、T.R. Seshadri

  DOI：10.1016/s0040-4020(01)98312-7

  日期：1965.1
• BIOACTIVE FRACTIONS AND COMPOUNDS FROM DALBERGIA SISSOO FOR THE PREVENTION OR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS
  申请人：Council of Scientific and Industrial Research

  公开号：EP2705047A1

  公开（公告）日：2014-03-12
• JPH06321798A
  申请人：——

  公开号：JPH06321798A

  公开（公告）日：1994-11-22