Latifolindiacetat | 18525-17-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Latifolindiacetat
• 英文别名: R-2',5-O-Diacetyl-latifolin；latifolin diacetate；[2-[(1R)-1-(5-acetyloxy-2,4-dimethoxyphenyl)prop-2-enyl]phenyl] acetate
• CAS: 18525-17-2
• 化学式: C₂₁H₂₂O₆
• 分子量: 370.402
• InChiKey: JOGYACZATMMYNJ-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  阔叶黄檀酚 、 乙酸酐 在 吡啶 作用下， 生成 Latifolindiacetat
  参考文献：
  名称：

  宪法Ø二甲基latifolin

  摘要：

  Dalbergia latifolia心材的轻质石油提取物，生成无色结晶固体latifolin，它是具有类似于dalbergin的C 15骨架的二羟基二甲基化合物。二甲醚的组成显示为γ，γ-（2,2'，4,5-四甲氧基）-二苯基丙烯（II）。

  DOI：

  10.1016/s0040-4020(01)99307-x

文献信息

• Constitution of o-dimethyl latifolin
  作者：S. Balakrishna、M.M. Rao、T.R. Seshadri

  DOI：10.1016/s0040-4020(01)99307-x

  日期：1962.1

  Dalbergia latifolia, yields a colourless crystalline solid, latifolin, which is a dihydroxy, dimethyl compound having a C15 skeleton similar to dalbergin. The constitution of the dimethyl ether is shown to be γ,γ-(2,2′,4,5-tetramethoxy)-diphenyl propene (II).

  Dalbergia latifolia心材的轻质石油提取物，生成无色结晶固体latifolin，它是具有类似于dalbergin的C 15骨架的二羟基二甲基化合物。二甲醚的组成显示为γ，γ-（2,2'，4,5-四甲氧基）-二苯基丙烯（II）。
• Bioactivity of Latifolin and Its Derivatives against Termites and Fungi
  作者：Nobuhiro Sekine、Tatsuya Ashitani、Tetsuya Murayama、Sakae Shibutani、Satoshi Hattori、Koetsu Takahashi

  DOI：10.1021/jf900719p

  日期：2009.7.8

  Latifolin (1) and its derivatives were investigated with the aim of confirming the correlation between bioactivity (antitermite and antifungal activity) and chemical structure. Termite mortality in response to the derivatives 2'-O-methyllatifolin (2), latifolin dimethyl ether (4), and latifolin diacetate (5) increased 2-fold compared to compound 1. The mortality rate from 5-O-methyllatifolin (3) was not different from 1. The mass loss (feed consumption by termite) in response to compounds 3-5 was 3 times greater than compound 1, and the mass loss from compound 2 was twice as great as compound 1. The mortality rate from compounds 4 and 5 increased sharply 7 days after initial exposure. In assessing the antifungal activity of these compounds, it was found that the inhibition rates of white- and brown-rot fungi in response to all derivatives were less than that for compound 1. Our findings indicate that the phenolic hydroxyl group at C-5 of the A ring provides antitermite activities (mortality and mass loss). In addition, both C-5 and C-2' phenolic hydroxyl groups in the A and B rings have antifungal activity against white- and brown-rot fungi. In conclusion, the bioactivity of compound 1 depends upon the position of phenolic hydroxyl groups,