2,6-二氯-N-乙基-4-嘧啶胺 | 70958-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2,6-二氯-N-乙基-4-嘧啶胺
• 中文别名: 2,6-二氯-N-乙基嘧啶-4-胺
• 英文名称: 2,6-dichloro-4-ethylaminopyrimidine
• 英文别名: (2,6-dichloro-pyrimidin-4-yl)-ethyl-amine；2,6-Dichloro-N-ethylpyrimidin-4-amine
• CAS: 70958-39-3
• 化学式: C₆H₇Cl₂N₃
• 分子量: 192.048
• InChiKey: KUCGOWHTYNSROR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  2,6-二氯-N-乙基-4-嘧啶胺 在 盐酸 、 甲醇 、 镍 、 sodium hydride 作用下， 以 水 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 23.0h， 生成 6--4(3H)-pyrimidinone
  参考文献：
  名称：

  Simplified Analogues of Acyclonucleosides. Synthesis of 6-[N-Alkyl-N-(4-hydroxybutyl)amino]pyrimidine Derivatives

  摘要：

  The synthesis of some 6-alkylaminopyrimidine derivatives bearing a 4-hydroxybutyl chain as sugar mimic is described. These new compounds can be regarded as simplified, ring-opened analogues of purine acyclonucleosides.

  DOI：

  10.1080/15257779408009479
• 作为产物：
  描述：

  4-氨基-2,6-二氯嘧啶 、 碘乙烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以26%的产率得到2,6-二氯-N-乙基-4-嘧啶胺
  参考文献：
  名称：

  Simplified Analogues of Acyclonucleosides. Synthesis of 6-[N-Alkyl-N-(4-hydroxybutyl)amino]pyrimidine Derivatives

  摘要：

  The synthesis of some 6-alkylaminopyrimidine derivatives bearing a 4-hydroxybutyl chain as sugar mimic is described. These new compounds can be regarded as simplified, ring-opened analogues of purine acyclonucleosides.

  DOI：

  10.1080/15257779408009479

文献信息

• SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS
  申请人：Arasappan Ashok

  公开号：US20110318305A1

  公开（公告）日：2011-12-29

  The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
• ETHYNYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS
  申请人：Kwong Cecil D.

  公开号：US20120107271A1

  公开（公告）日：2012-05-03

  The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
• US8541434B2
  申请人：——

  公开号：US8541434B2

  公开（公告）日：2013-09-24
• US9433621B2
  申请人：——

  公开号：US9433621B2

  公开（公告）日：2016-09-06
• Simplified Analogues of Acyclonucleosides. Synthesis of 6-[N-Alkyl-N-(4-hydroxybutyl)amino]pyrimidine Derivatives
  作者：M. Botta、R. Saladino、M. Anzini、F. Corelli

  DOI：10.1080/15257779408009479

  日期：1994.9

  The synthesis of some 6-alkylaminopyrimidine derivatives bearing a 4-hydroxybutyl chain as sugar mimic is described. These new compounds can be regarded as simplified, ring-opened analogues of purine acyclonucleosides.