2,6-二氯苯乙基溴 | 40173-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二氯苯乙基溴
• 英文名称: 2,6-dichlorophenethyl bromide
• 英文别名: 2-(2,6-Dichlorophenyl)ethyl bromide；2-(2-Bromoethyl)-1,3-dichlorobenzene
• CAS: 40173-94-2
• 化学式: C₈H₇BrCl₂
• 分子量: 253.954
• InChiKey: ZWMPYIRPUBVKPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,6-二氯苯乙基溴 在 sodium sulfite 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以89.8%的产率得到sodium 2,6-dichloro-b-phenethylsulfonate
  参考文献：
  名称：

  Solution and flash vacuum pyrolysis of some 2,6-disubstituted .beta.-phenethylsulfonyl azides and of .beta.-styrenesulfonyl azide

  摘要：

  DOI：

  10.1021/jo00212a013

文献信息

• Pyridine derivatives and insecticide and miticide comprising said
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US05262420A1

  公开（公告）日：1993-11-16

  A pyridine compound of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms or a haloalkoxyl group having 1 to 4 carbon atoms, n is 1 to 5, and when n is 2 or more, Xs may be identical to or different from each other, A is an alkyl residue or alkene residue in which a portion connecting the aryl group with the 4-position of the pyridyl group has 3 to 8 carbon atoms, or an alkapolyene residue in which said portion has 4 to 8 carbon atoms and 2 to 4 double bonds; the alkyl residue, alkene residue, and alkapolyene residue may have an alkyl side chain having 1 to 4 carbon atoms, an alkylidene side chain having 1 to 4 carbon atoms or 1 to 16 halogen atoms, and when there are 2 or more side chains, the side chains may be identical to or different from each other, and R.sup.1 and R.sup.2 are each a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or salts thereof. The pyridine compounds and salts thereof exhibit a strong insecticidal and miticidal activity and are low in residuality and accumulativity and are thus useful as insecticides and miticides for the control of pests in agriculture and horticulture.

  一种杂环化合物，其分子式为##STR1##，其中X为氢原子、卤素原子、1至4个碳原子的烷基、1至4个碳原子的烷氧基、1至4个碳原子的卤代烷基或1至4个碳原子的卤代烷氧基；n为1至5，当n为2个或更多时，X可以相同也可以不同；A为连接芳基和吡啶基4位的部分含有3至8个碳原子的烷基残基或烯基残基，或含有4至8个碳原子和2至4个双键的烯丙基残基；烷基残基、烯基残基和烯丙基残基可以含有1至4个碳原子的烷基侧链、1至4个碳原子或1至16个卤素原子的亚烷基侧链，当存在2个或更多侧链时，侧链可以相同也可以不同；R1和R2各自为氢原子或含有1至6个碳原子的烷基，或其盐。这些杂环化合物及其盐类具有强烈的杀虫和杀螨活性，且残留性和积累性低，因此作为杀虫剂和杀螨剂用于农业和园艺中控制害虫非常有用。
• Novel 4-phenylpiperidines for the treatment of pruritic dermatoses
  申请人：——

  公开号：US20030078282A1

  公开（公告）日：2003-04-24

  Novel compounds having general formula (I), and pharmaceutically and veterinarily acceptable salts thereof wherein R 1, R 2, R 3, W, Y 1, Y 2, X, n and y are as defined above and processes for their preparation and intermediate compounds prepared therein. The novel compounds are useful for having utility in the treatment. of pruritic dermatoses including allergic dermatitis and atopy in animals and humans

  具有通用公式(I)的新化合物，以及药物和兽药可接受的盐，其中R 1、R 2、R 3、W、Y 1、Y 2、X、n和y如上所述定义，以及它们的制备过程和其中制备的中间化合物。这些新化合物在治疗包括动物和人类的瘙痒性皮肤病，包括过敏性皮炎和异位症方面具有用途。
• The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments
  作者：Meining Wang、Thomas C. Irvin、Christine A. Herdman、Ramsey D. Hanna、Sergio A. Hassan、Yong-Sok Lee、Sophia Kaska、Rachel Saylor Crowley、Thomas E. Prisinzano、Sarah L. Withey、Carol A. Paronis、Jack Bergman、Saadet Inan、Ellen B. Geller、Martin W. Adler、Theresa A. Kopajtic、Jonathan L. Katz、Aaron M. Chadderdon、John R. Traynor、Arthur E. Jacobson、Kenner C. Rice

  DOI：10.3390/molecules25112640

  日期：——

  the aromatic ring of the N-phenethyl moiety. One compound, N-p-chloro-phenethynorhydromorphone ((7aR,12bS)-3-(4-chlorophenethyl)-9-hydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one, 2i), was found to have nanomolar binding affinity at MOR and DOR. It was a potent partial agonist at MOR and a full potent agonist at DOR with a δ/μ potency ratio of 1.2 in the ([35S]GTPγS)

  (−)-N-苯乙基类似物的光学纯 N-去甲氢吗啡酮被合成并在几个体外试验中进行药理学评估（阿片受体结合、[35S]GTPγS 结合的刺激、毛喉素诱导的 cAMP 积累试验和 MOR 介导的 β-抑制素募集测定）。“体”和“尾”与阿片受体的相互作用（Portoghese 信息地址理论的一个子集）被用于分子建模和模拟，其中“地址”可以被认为是氢吗啡酮分子的“主体”和“信息”由 N-苯乙基部分芳环上的取代基（尾）传递。一种化合物，Np-chloro-phenethynorhydromorphone ((7aR,12bS)-3-(4-chlorophenethyl)-9-hydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3 ,2-e]isoquinolin-7(7aH)-one, 2i), 发现在 MOR 和 DOR 处具有纳摩尔结合亲和力。它是
• Pharmaceutical compositions and methods of treating hypertension
  申请人：John Wyeth & Brother Limited

  公开号：US04029801A1

  公开（公告）日：1977-06-14

  Pharmaceutical compositions containing a group of heterocyclic compounds and their use in treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds used in the composition and/or methods are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted cycloalkyl, aryl or heterocyclic radical through the intermediary of a group selected from a lower-alkylene radical, a monoketo lower-alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula --NH.CO.(CH.sub.2).sub.n -- where n is 1, 2 or 3, ##STR1## or --0-(lower-alkylene)--. The piperidine ring is further substituted by an acylamino residue.

  本发明描述了含有杂环化合物组的药物组合物及其在治疗心血管系统疾病和/或治疗浅表和深层过敏现象中的应用。这些组合物和/或方法中使用的化合物是哌啶化合物，通过氮原子与取代或未取代的环烷基、芳基或杂环基团相连，中间通过一个选自低级烷叉基、单酮低级烷叉基或羟基低级烷叉基的基团，或一个二价基团，其公式为--NH.CO.(CH.sub.2).sub.n --，其中n为1、2或3，##STR1##或--O-(低级烷叉基)--。哌啶环进一步被酰胺基残基取代。
• [EN] SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS<br/>[FR] DÉRIVÉS D'AMINES SPIRO-CYCLIQUES EN TANT QUE MODULATEURS DE S1P
  申请人：ABBOTT HEALTHCARE PRODUCTS BV

  公开号：WO2012004378A1

  公开（公告）日：2012-01-12

  The present invention relates spiro- cyclic amine derivatives of the formula (I) wherein R1; R2; R3; Q; -W-T-; R5; Z; and A have the definitions provided in the claims; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more N-oxides thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of diseases and conditions in which (a) S1P receptor (s) is (are) involved.

  本发明涉及式(I)的螺环胺衍生物，其中R1; R2; R3; Q; -W-T-; R5; Z; 和A具有索赔中提供的定义；或者其药学上可接受的盐、溶剂合物或水合物，或一个或多个N-氧化物。本发明的化合物具有对S1P受体的亲和力，并可用于治疗、缓解或预防涉及S1P受体的疾病和症状。