2,6-二甲基-3,5-二溴吡啶 | 3430-34-0

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二甲基-3,5-二溴吡啶
• 英文名称: 2,6-dimethyl-3,5-dibromopyridine
• 英文别名: 3,5-dibromo-2,6-dimethylpyridine；3,5-dibromo-2,6-dimethyl-pyridine；3,5-Dibrom-2,6-dimethyl-pyridin；3.5-Dibrom-lutidin-(2.6)
• CAS: 3430-34-0
• 化学式: C₇H₇Br₂N
• 分子量: 264.947
• InChiKey: CTOFYKSVKNMNGB-UHFFFAOYSA-N

物化性质

• 熔点：
  46-57 °C
• 沸点：
  240.2±35.0 °C(Predicted)
• 密度：
  1.795±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3,5-Dibromo-2,6-dimethylpyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3,5-Dibromo-2,6-dimethylpyridine
CAS number: 3430-34-0

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H7Br2N
Molecular weight: 264.9

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,6-二甲基-3,5-二溴吡啶 在 正丁基锂 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium carbonate 、 三氟乙酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 2.42h， 生成 4-(5-fluoro-2,6-dimethylpyridin-3-yl)-2-hydroxycyclohepta-2,4,6-trien-1-one
  参考文献：
  名称：

  [EN] TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS
  [FR] DÉRIVÉS DE TROPOLONE ET LEURS TAUTOMÈRES POUR LA RÉGULATION DU FER CHEZ LES ANIMAUX

  摘要：

  本文披露了一系列化合物或其互变异构体，其具有由化学式Ia或Ib表示的一般结构以及其药学上可接受的盐。还披露了包括所述化合物或互变异构体或其药学上可接受的盐的药物组合物。进一步的披露涉及一种治疗与铁调节失调或铁稳态功能异常相关的疾病或症状的方法，包括向需要的受试者施用化学式Ia或Ib化合物或互变异构体或其药学上可接受的盐的治疗有效量。

  公开号：

  WO2021076945A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溴 作用下， 生成 2,6-二甲基-3,5-二溴吡啶
  参考文献：
  名称：

  Pfeiffer, Chemische Berichte, 1887, vol. 20, p. 1351

  摘要：

  DOI：

文献信息

• [EN] 5, 7-DIHYDRO- 6H-PYRIMIDO [ 5, 4-D] [ 1 ] BENZAZEPIN-6-THIONES AS PLK INHIBITORS<br/>[FR] 5, 7-DIHYDRO- 6H-PYRIMIDO [ 5, 4-D] [ 1 ] BENZAZÉPIN-6-THIONES UTILISÉES EN TANT QU'INHIBITEURS DE PLK
  申请人：MILLENNIUM PHARM INC

  公开号：WO2010065134A1

  公开（公告）日：2010-06-10

  This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

  本发明提供了公式I的化合物：其中R1、R2、R3、R4、R5和R6如说明书所述。这些化合物是PLK的抑制剂，因此可用于治疗增殖性、炎症性或心血管疾病。
• PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
  申请人：Navitor Pharmaceuticals, Inc.

  公开号：US20180127370A1

  公开（公告）日：2018-05-10

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用它们的方法。
• [EN] PHENYL mTORC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE MTORC PHÉNYLE ET LEURS UTILISATIONS
  申请人：NAVITOR PHARM INC

  公开号：WO2018089433A1

  公开（公告）日：2018-05-17

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用相同的方法。
• A Suzuki-Miyaura Approach to a Series of Forensically Relevant Pyridines
  作者：Zbigniew Czarnocki、Dariusz Błachut、Krystyna Wojtasiewicz

  DOI：10.1055/s-2006-942535

  日期：2006.9

  A convenient and general method for the preparation of sixteen 3,5-diarylsubstituted 2,4- and 2,6-dimethylpyridines of high forensic importance is described. The Suzuki cross-coupling reaction between a range of ring-substituted phenylboronic acids and 3,5-dibromo-2,4-dimethylpyridine and 3,5-dibromo-2,6-dimethylpyridine was used as a key step.

  本文介绍了制备十六种具有重要法医意义的 3,5 二取代 2,4- 和 2,6 二甲基吡啶的简便通用方法。一系列环取代的苯硼酸与 3,5-二溴-2,4-二甲基吡啶和 3,5-二溴-2,6-二甲基吡啶之间的铃木交叉偶联反应被用作关键步骤。
• Three isoreticular ssa-type MOFs derived from bent diisophthalate ligands: exploring the substituent effect on structural stabilities and selective C₂H₂/CH₄ and CO₂/CH₄ adsorption properties
  作者：Yao Wang、Minghui He、Xiaoxia Gao、Piao Long、Yingying Zhang、Haoyan Zhong、Xia Wang、Yabing He

  DOI：10.1039/c8dt02686f

  日期：——

  the effect of the substituents on structural stabilities and gas adsorption properties of MOFs is fundamentally important for rational design and synthesis of new MOFs with better performance. For this purpose, three isoreticular copper-based MOFs (ZJNU-87, ZJNU-88 and ZJNU-89) with ssa-type topology were successfully constructed from bent diisophthalate ligands bearing different substituents. Permanent

  评估取代基对MOF的结构稳定性和气体吸附性能的影响，对于合理设计和合成性能更好的新型MOF至关重要。为此，成功地从带有不同取代基的二间苯二酚弯曲配体上构建了三个具有ssa型拓扑结构的等网状铜基MOF（ZJNU -87，ZJNU-88和ZJNU-89）。永久孔隙率研究表明，取代基对骨架抗去溶剂化的稳定性有重大影响。利用非极性Ñ己烷作为激活溶剂可提供更多的优化的永久多孔性非极性或较小极性取代基改性的浙江师范大学-88和浙江师范大学-89。此外，系统地研究了它们对C 2 H 2，CO 2和CH 4的气体吸附性能，揭示了它们有选择性分离C 2 H 2 / CH 4和CO 2 / CH 4的潜力。特别地，就吸收容量和吸附选择性而言，甲氧基改性的ZJNU-89的性能优于甲基改性的ZJNU-88，这可能归因于ZJNU-89的更合适的孔空间。