沙克列汀相关杂质 | 361441-98-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 沙克列汀相关杂质
• 英文名称: 3-Deoxy Saxagliptin
• 英文别名: (1S,3S,5S)-2-[(2S)-2-(1-adamantyl)-2-aminoacetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• CAS: 361441-98-7
• 化学式: C₁₈H₂₅N₃O
• 分子量: 299.4
• InChiKey: CNEBXOWFQASQAR-FTDXYOEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
  申请人：Bernardelli Patrick

  公开号：US20090281084A1

  公开（公告）日：2009-11-12

  The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. What are described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

  本发明涉及具有苯基的苯基-1,2,4-噁二唑酮衍生物及其生理上可接受的盐和生理上功能衍生物，显示PPARδ激动剂活性。所描述的是式I的化合物，其中基团如定义所述，以及它们的生理上可接受的盐和它们的制备方法。这些化合物适用于治疗和/或预防脂肪酸代谢障碍和葡萄糖利用障碍以及胰岛素抵抗涉及的障碍以及中枢和外周神经系统的脱髓鞘和其他神经退行性疾病。
• Protected amino hydroxy adamantane carboxylic acid and process for its preparation
  申请人：AstraZeneca AB

  公开号：EP2272825B1

  公开（公告）日：2015-11-04
• EP2995615A1
  申请人：——

  公开号：EP2995615A1

  公开（公告）日：2016-03-16
• US7851493B2
  申请人：——

  公开号：US7851493B2

  公开（公告）日：2010-12-14