2,6-二甲基哌啶 | 504-03-0

• 物质功能分类: 原料药 - 循环系统用药 - 抗高血压病药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2,6-二甲基哌啶
• 中文别名: 二甲哌啶
• 英文名称: 2.6-dimethylpiperidine
• 英文别名: 2,6-Dimethylpiperidin；2,6-Dimethylpiperidine
• CAS: 504-03-0
• 化学式: C₇H₁₅N
• mdl: MFCD00005986
• 分子量: 113.203
• InChiKey: SDGKUVSVPIIUCF-UHFFFAOYSA-N

物化性质

• 沸点：
  127-128 °C768 mm Hg(lit.)
• 密度：
  0.84 g/mL at 25 °C(lit.)
• 闪点：
  53 °F
• 溶解度：
  溶于二甲基亚砜
• 保留指数：
  834;873;833
• 稳定性/保质期：
  按规格使用和贮存，不会发生分解，并应避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• TSCA：
  Yes
• 危险等级：
  3
• 危险品标志：
  F,Xi,C
• 安全说明：
  S16,S26,S36/37/39
• 危险类别码：
  R34,R36/37/38,R11
• WGK Germany：
  3
• 海关编码：
  2933399090
• 危险品运输编号：
  UN 1993 3/PG 2
• RTECS号：
  OK5775000
• 包装等级：
  II
• 危险类别：
  3
• 危险性防范说明：
  P242,P264,P271,P280,P301+P330+P331,P304+P340,P305+P351+P338,P310,P363,P370+P378,P403+P233,P501
• 危险性描述：
  H225,H314
• 储存条件：
  密封保存，并置于通风、干燥的环境中。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2,6-Dimethylpiperidine
Synonyms: 2,6-Lupetidine

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2,6-Dimethylpiperidine
CAS number: 504-03-0

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H15N
Molecular weight: 113.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生物活性方面，Nanofin (2,6-二甲基奎宁) 是一种神经性阻断药物，具有显著的降压作用，适用于研究轻中度高血压。

反应信息

• 作为反应物：
  描述：

  2,6-二甲基哌啶 在 盐酸 作用下， 以 1,4-二氧六环 、 正戊烷 为溶剂， 以98%的产率得到cis-2,6-dimethyl-piperidine; hydrochloride
  参考文献：
  名称：

  Metal-Free Hydrogenation of N-Based Heterocycles

  摘要：

  Metal-free hydrogenation of substituted pyridines, quinolines, and several other N-heterocycles is achieved upon treatment of the nitrogen-based Lewis base with an equivalent of the Lewis acid B(C6F5)(3) and H-2 (4 atm) at 115 degrees C, to afford the ammonium-[HB(C6F5)(3)] salts of the reduced N-heterocycles.

  DOI：

  10.1021/om4000727
• 作为产物：
  描述：

  1-甲基己-5-烯基胺 在 (CH2)2[N(2,6-diethylphenyl)]2 yttrium(III)N(trimethylsilyl)2 作用下， 生成 2,6-二甲基哌啶
  参考文献：
  名称：

  在钇和钕酰胺基络合物催化的分子内烯烃加氢胺化反应中，通过螯合二酰胺配位，可异常提高速率并改善非对映选择性。

  摘要：

  DOI：

  10.1002/1521-3773(20021004)41:19<3645::aid-anie3645>3.0.co;2-f
• 作为试剂：
  描述：

  聚合甲醛 、 磷酰基乙酸三乙酯 在 2,6-二甲基哌啶 作用下， 生成 ethyl 2-diethoxyphosphinoylacrylate
  参考文献：
  名称：

  Levy, Jeffrey N.; Mckenna, Charles E., Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 85, # 1-4, p. 1 - 8

  摘要：

  DOI：

文献信息

• [EN] GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE<br/>[FR] PHOSPHORAMIDITES GALNAC, LEURS CONJUGUÉS D'ACIDES NUCLÉIQUES ET LEUR UTILISATION
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016055601A1

  公开（公告）日：2016-04-14

  This invention generally relates to the field of phosphoramidite derivatives. In particular, the invention relates to N-Acetylgalactosamine phosphoramidite molecules and to conjugates of nucleic acid molecules with N-Acetylgalactosamine containing molecules. Also provided are methods for preparation of these molecules and possible uses thereof, in particular in medicine.

  这项发明通常涉及磷酰胺酰胺衍生物领域。具体而言，该发明涉及N-乙酰半乳糖磷酰胺分子以及含有N-乙酰半乳糖胺的核酸分子的共轭物。还提供了制备这些分子以及可能用途的方法，特别是在医学领域。
• [EN] SULFONYLATED TETRAHYDROAZOLOPYRAZINES AND THEIR USE AS MEDICINAL PRODUCTS<br/>[FR] TÉTRAHYDROAZOLOPYRAZINES SULFONYLÉES ET LEUR UTILISATION EN TANT QUE PRODUITS MÉDICAMENTEUX
  申请人：GRUENENTHAL GMBH

  公开号：WO2010099938A1

  公开（公告）日：2010-09-10

  The present invention relates to sulfonylated tetrahydroazolopyrazines, methods for the preparation thereof, medicinal products containing these compounds and the use of substituted indole compounds for the preparation of medicinal products (Formula I).

  本发明涉及磺酰化四氢咯啉吡嗪，其制备方法，含有这些化合物的药物产品以及用于制备药物产品的取代吲哚化合物的使用（式I）。
• [EN] UREA DERIVATIVES OF AMPHOTERICIN B DERIVED FROM SECONDARY AMINES<br/>[FR] DÉRIVÉS D'URÉE DE L'AMPHOTÉRICINE B DÉRIVÉE D'AMINES SECONDAIRES
  申请人：UNIV ILLINOIS

  公开号：WO2016112243A1

  公开（公告）日：2016-07-14

  Provided are certain urea derivatives of amphotericin B (AmB) having improved therapeutic index compared to AmB. The compounds of the invention are less toxic than AmB and are useful to treat fungal infections. In certain embodiments the urea derivative of AmB is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: R represents methyl, ethyl, propyl, or isopropyl; R' represents methyl, ethyl, propyl, or isopropyl; or R and R', taken together with the nitrogen atom to which they are attached, represent a radical of a cyclic secondary amine. Also provided are methods for making the urea derivatives of AmB.

  提供了与两性霉素B（AmB）相比具有改善的治疗指数的某些尿素衍生物。本发明的化合物比AmB毒性更小，并且可用于治疗真菌感染。在某些实施例中，AmB的尿素衍生物是由以下式（I）表示的化合物或其药用可接受的盐：其中，对于每次出现独立地：R代表甲基、乙基、丙基或异丙基；R'代表甲基、乙基、丙基或异丙基；或R和R'与它们连接的氮原子一起表示环状二级胺的基团。还提供了制备AmB的尿素衍生物的方法。
• A Manganese Pre-Catalyst: Mild Reduction of Amides, Ketones, Aldehydes, and Esters
  作者：Colin M. Kelly、Robert McDonald、Orson L. Sydora、Mark Stradiotto、Laura Turculet

  DOI：10.1002/anie.201709441

  日期：2017.12.11

  Hey Man(ganese): A newly prepared (N-phosphinoamidinate)manganese pre-catalyst (see Scheme) has been shown to be effective for the hydrosilative reduction of a diverse scope of carbonyl compounds, and in most cases can be used at room temperature. The reaction proceeds under reaction conditions which are competitive with the most effective transition-metal catalysts known for such transformations,

  Hey Man（ganese）：新制备的N-膦酰胺基锰预催化剂（参见方案）可有效地对各种范围的羰基化合物进行氢化硅烷化还原，在大多数情况下可在室温下使用。该反应在与已知用于这种转化的最有效的过渡金属催化剂竞争的反应条件下进行，从而建立了一类新的合成上有用的Mn催化的转化。
• [EN] INHIBITOR OF INDOLEAMINE-2,3-DIOXYGENASE (IDO)<br/>[FR] INHIBITEUR DE L'INDOLÉAMINE-2,3-DIOXYGÉNASE (IDO)
  申请人：INVENTISBIO INC

  公开号：WO2017139414A1

  公开（公告）日：2017-08-17

  The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

  本公开提供了式（I）的化合物。本文描述的化合物可能在治疗与IDO相关的疾病方面有用，例如癌症或传染病（例如病毒或细菌感染性疾病）。本公开还提供了包括或使用本文描述的化合物的药物组合物、试剂盒、方法和用途。

表征谱图