2,6-二甲基苯磺酰胺 | 24010-56-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二甲基苯磺酰胺
• 英文名称: 2,6-dimethylbenzenesulfonamide
• 英文别名: 2,6-Dimethylbenzolsulfonamid；2,6-dimethyl-benzenesulfonic acid amide；2,6-Dimethyl-benzolsulfonsaeure-amid
• CAS: 24010-56-8
• 化学式: C₈H₁₁NO₂S
• 分子量: 185.247
• InChiKey: ZEBMBNNVUIWRIC-UHFFFAOYSA-N

物化性质

• 熔点：
  112-113 °C
• 沸点：
  344.3±52.0 °C(Predicted)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  2,6-二甲基苯磺酰胺 在 氯化亚砜 作用下， 以 乙醇 为溶剂， 生成 2,2’-二硫双(3-甲基苯甲酸)
  参考文献：
  名称：

  Herbicidal compounds, their production and use

  摘要：

  一种通式为##STR1##的化合物，其中R.sub.1是苯基，可以被取代，R.sub.2和R.sub.3分别是较低的烷基或较低的烷氧基，Z是CH或N，n为0或1，或其盐，可用作除草剂。

  公开号：

  US04897105A1
• 作为产物：
  描述：

  2,6-二甲基苯-1-磺酰氯 在 ammonium hydroxide 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 2,6-二甲基苯磺酰胺
  参考文献：
  名称：

  Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

  摘要：

  Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.054

文献信息

• UREA DERIVATIVE AND ADHESIVE-MOLECULE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1323709A1

  公开（公告）日：2003-07-02

  Disclosed are novel urea derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The urea derivative according to the present invention has the chemical structure, for example, represented by the following Formula (35):

  揭示了新颖的尿素衍生物及其医药用途，特别是作为粘附分子抑制剂，用于治疗炎症性疾病。根据本发明的尿素衍生物具有化学结构，例如，由以下化学式（35）表示：
• [EN] SUBSTITUTED SULFONAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS DE SULFONAMIDE SUBSTITUÉS
  申请人：GRUENENTHAL GMBH

  公开号：WO2009109364A1

  公开（公告）日：2009-09-11

  The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.

  这项发明涉及替代磺胺基衍生物，其制备方法，含有这些化合物的药物以及利用替代磺胺基衍生物制备药物。
• Piperidine derivatives useful as modulators of chemokine receptor activity
  申请人：——

  公开号：US20040235894A1

  公开（公告）日：2004-11-25

  The invention provides a compound of formula (I), wherein: T is C(O) or S(O) 2 ; W is C(O) or S(O) 2 ; X is CH 2 , O or NH; Y is CR 5 or N; R 1 is optionally substituted aryl or optionally substituted heterocyclyl; R 2 is hydrogen or C 1-6 alkyl; R 3 is hydrogen or optionally substituted C 1-6 alkyl; and R 4 is alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis. 1

  该发明提供了一个化合物的公式（I），其中：T为C（O）或S（O）2；W为C（O）或S（O）2；X为CH2，O或NH；Y为CR5或N；R1为可选择替代芳基或可选择替代杂环基；R2为氢或C1-6烷基；R3为氢或可选择替代C1-6烷基；R4为烷基，可选择替代芳基，可选择替代芳基烷基或可选择替代杂环基；这些化合物是趋化因子（尤其是CCR3）活性的调节剂，特别适用于治疗哮喘和/或鼻炎。
• Urea derivative and adhesive-molecule inhibitor containing the same as active ingredient
  申请人：——

  公开号：US20040039040A1

  公开（公告）日：2004-02-26

  Disclosed are novel urea derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The urea derivative according to the present invention has the chemical structure, for example, represented by the following Formula (35): 1

  本发明涉及新型尿素衍生物及其医药用途，特别是作为粘附分子抑制剂，用于治疗炎症性疾病。根据本发明，所述尿素衍生物具有化学结构，例如由以下式（35）表示：1。
• Polymer modified adducts of epoxy resins and active hydrogen containing compounds containing mesogenic moieties
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0469492A2

  公开（公告）日：1992-02-05

  Polymer modified adducts are prepared by (A) reacting (1) an epoxy resin having an average of more than one vicinal epoxide group with (2) a compound containing an average of two or more hydrogen atoms reactive with an epoxide group; and (B) partially vinylizing reacting the product from step (A); and (C) polymerizing the partially vinylized product from step (B) with (3) a polymerizable ethylenically unsaturated monomer; with the proviso that at least one of the components (1), (2) or (3) contain one or more mesogenic or rodlike moieties. These adducts are useful as epoxy resin curing agents.

  聚合物改性加合物的制备方法是：(A)将(1)具有平均一个以上副环氧基团的环氧树脂与(2)含有平均两个或两个以上与环氧基团反应的氢原子的化合物反应；以及(B)将步骤(A)的产物部分乙烯基化；(C) 将步骤(B)的部分乙烯基化产物与(3)可聚合的乙烯基不饱和单体聚合；但条件是组分(1)、(2)或(3)中至少有一种含有一个或多个介原或棒状分子。这些加合物可用作环氧树脂固化剂。