2,6-双[(5-氯-2-羟基苯基)甲基]-4-甲基苯酚 | 100267-42-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 中文名称: 2,6-双[(5-氯-2-羟基苯基)甲基]-4-甲基苯酚
• 英文名称: 2,6-bis(5-chloro-2-hydroxybenzyl)-4-methylphenol
• 英文别名: Phenol, 2,6-bis[(5-chloro-2-hydroxyphenyl)methyl]-4-methyl-；2,6-bis[(5-chloro-2-hydroxyphenyl)methyl]-4-methylphenol
• CAS: 100267-42-3
• 化学式: C₂₁H₁₈Cl₂O₃
• 分子量: 389.278
• InChiKey: HAWFXQMHXZGTAU-UHFFFAOYSA-N

物化性质

• 熔点：
  233-235 °C
• 沸点：
  559.5±45.0 °C(Predicted)
• 密度：
  1.372±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-双[(5-氯-2-羟基苯基)甲基]-4-甲基苯酚 、 乙酸酐 在 sodium acetate 作用下， 生成 2-acetoxy-1,3-bis-(2-acetoxy-5-chloro-benzyl)-5-methyl-benzene
  参考文献：
  名称：

  The effects of grades on course enjoyment: Did you get the grade you wanted?

  摘要：

  Background. Students tend to rate university courses more positively if they do well. Greenwald and Gillmore (1997a) suggested that it is not students’ absolute grades that are important but rather how these grades compare to their expectations. However, this hypothesis is difficult to evaluate because few studies have measured grade expectations at the beginning of courses. Aim. By measuring students’ grade expectations and enjoyment at several stages during a course, we hoped to evaluate the extent to which expectations modulate the impact of grades on course enjoyment. Sample. Participants were 242 students in a university course in psychology. Method. Students were asked what grades they expected, and how much they were enjoying the course, at four stages. The effect of grades and grade expectations on enjoyment were analysed using restricted maximum likelihood (REML) and regression analyses. Results. The best predictor of course enjoyment varied somewhat at different stages, but in general it was the extent to which students’ grades surpassed their expectations. Students’ expectations at the beginning of the course proved particularly influential. Conclusions. Grade expectations do influence how students react to course grades, but the prominent role of pre‐course expectations suggests that it may be important to distinguish between grade aspirations and grade expectations. It appears to be students’ aspirations ‐ the grades they hope to achieve ‐ that most strongly shape their emotional reactions, rather than the more realistic expectations they may form later in a course.

  DOI：

  10.1348/000709900158173
• 作为产物：
  描述：

  2-羟基-5-甲基间苯二甲醇 在 盐酸 、 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate 、 zinc(II) oxide 作用下， 以 水 为溶剂， 反应 0.02h， 生成 2,6-双[(5-氯-2-羟基苯基)甲基]-4-甲基苯酚
  参考文献：
  名称：

  Bargebid, Rahele; Khabnadideh, Soghra, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2020, vol. 59, # 12, p. 1893 - 1902

  摘要：

  DOI：

文献信息

• An Efficient Synthetic Approach to Substituted Trisphenols (Phloroglucide Analogues) Using Tungstosilicic Acid in Water
  作者：Reza Fareghi-Alamdari、Ali Khalafi-Nezhad、Negar Zekri

  DOI：10.1055/s-0033-1340681

  日期：——

  Abstract Tungstosilicic acid was found to be an efficient catalyst for the synthesis of trisphenols using the reaction of 2,6-bis(hydroxymethyl)phenols with phenols in an aqueous medium. The catalytic reactivity of tungstosilicic acid in boiling water was examined with a series of substrates, demonstrating that this catalyst is reactive in the presence of a variety of functionalities. Tungstosilicic acid

  摘要 发现钨硅酸是在水介质中使用2，6-双（羟甲基）苯酚与苯酚的反应合成三苯酚的有效催化剂。用一系列的底物检查了钨硅酸在沸水中的催化反应活性，表明该催化剂在多种官能团存在下具有反应性。 发现钨硅酸是在水介质中使用2，6-双（羟甲基）苯酚与苯酚的反应合成三苯酚的有效催化剂。用一系列的底物检查了钨硅酸在沸水中的催化反应活性，表明该催化剂在多种官能团存在下具有反应性。
• Solvent-free synthesis of trisphenols as starting precursors for the synthesis of calix[4]arenes using sulfonated multi-walled carbon nanotubes
  作者：Reza Fareghi-Alamdari、Mohsen Golestanzadeh、Negar Zekri

  DOI：10.1039/c5nj03136b

  日期：——

  enols (BMP) (6 examples) is reported using sulfonated multi-walled carbon nanotubes (SO3H@MWCNTs) under solvent-free conditions as starting precursors for the synthesis of macrocyclic molecules of calix[4]arenes. The new protocol provides a series of trisphenol derivatives (21 examples) in high yields (up to 94%) and relatively short reaction times (15–120 min). Also, direct synthesis of calix[4]arenes

  据报道，在无溶剂条件下使用磺化多壁碳纳米管（SO 3 H @ MWCNTs）作为苯酚衍生物（12种底物）与2,6-双（羟甲基）苯酚（BMP）的缩合（6个实例）用于合成杯[4]芳烃的大环分子。该新方案以高收率（高达94％）和相对较短的反应时间（15-120分钟）提供了一系列三酚衍生物（21个实例）。另外，已有报道通过使用催化剂由不同的三酚直接合成杯[4]芳烃（5个实例）。此外，合成的杯[4]芳烃是通过一锅法从简单易得的原料（如p）获得的。-甲酚合成5,11,17,23-四甲基杯[4]芳烃-25,26,27,28-四醇。同样，在此过程中，SO 3 H @ MWCNTs可以以几乎一致的效率重复使用七次，并且可以通过简单的过滤回收。
• Preparation and Bacteriostatic Properties of Substituted Trisphenols
  作者：David J. Beaver、Roland S. Shumard、Paul J. Stoffel

  DOI：10.1021/ja01118a030

  日期：1953.11
• Finn; Lewis, Journal of the Society of Chemical Industry, 1950, vol. 69, p. 132
  作者：Finn、Lewis

  DOI：——

  日期：——