油酸季戊四醇酯 | 25151-96-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 油酸季戊四醇酯
• 中文别名: 季戊四醇二油酸酯；二油酸季戊四醇酯；二油酸季戊四酯
• 英文名称: 2,2-bis(hydroxymethyl)propane-1,3-diyl dioleate
• 英文别名: pentaerythritol dioleate；Pentol；[2,2-bis(hydroxymethyl)-3-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
• CAS: 25151-96-6
• 化学式: C₄₁H₇₆O₆
• 分子量: 665.051
• InChiKey: BJXXCOMGRRCAGN-CLFAGFIQSA-N

物化性质

• 沸点：
  688.2±55.0 °C(Predicted)
• 密度：
  0.957±0.06 g/cm3(Predicted)
• LogP：
  14.622 (est)
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  13.7
• 重原子数：
  47
• 可旋转键数：
  38
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2916190090

反应信息

• 作为反应物：
  描述：

  油酸季戊四醇酯 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 2,2-bis(((3-((4-(dimethylamino)butyl)amino)propanoyl)oxy)methyl)propane-1,3-diyl dioleate
  参考文献：
  名称：

  [EN] POLYAMINE-MEDIATED TRANSFECTION
  [FR] TRANSFECTION A MEDIATION PAR POLYAMINE

  摘要：

  公开号：

  WO2003101952A3
• 作为产物：
  描述：

  2,2-dimethyl-5,5-bis(hydroxymethyl)-1,3-dioxane 在 盐酸 、 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 28.0h， 生成 油酸季戊四醇酯
  参考文献：
  名称：

  pH-responsive chitosan nanoparticles from a novel twin-chain anionic amphiphile for controlled and targeted delivery of vancomycin

  摘要：

  The design and synthesis of novel pH-responsive nanoantibiotics is an emerging research area to address the antibiotic resistance crisis. The purpose of this study was therefore to synthesize a new anionic gemini surfactant (AGS) that could result in the formulation of pH-responsive chitosan nanoparticles (CSNPs) to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. The coupling of oleic acid with 2,2-dimethy1-5,5-bis(hydroxymethyl)-1,3-dioxane and subsequent deprotection followed by a reaction with succinic anhydride and sodium bicarbonate yielded AGS. Critical micelle concentration (CMC) was determined using conductometry and in vitro cytotoxicity was performed using a MTT assay. Vancomycin loaded CSNPs containing AGS (DL(-)CSSNPs) were prepared by ionotropic gelation of chitosan with pentasodium tripolyphosphate. CSNPs were characterized for size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency, surface morphology, in vitro drug release and in vitro antibacterial activity (at pH 6.5 and 7.4). Results from-the in vitro antibacterial activity were further supported by an in vivo study using a mice skin infection model. The CMC of AGS was found to be 1.3 mM/L and it was non-toxic. The DLISSNPs were spherical with size, PDI and ZP of 220.57 +/- 5.9 nm, 0.299 +/- 0.004 and 21.9 +/- 0.9 mV respectively. An increase in the vancomycin release from the DL(-)CSSNPs was observed at pH 6.5 compared to pH 7.4. The minimum inhibitory concentration values at pH 6.5 and 7.4 against MRSA were 7.81 and 62.5 mu g/ml respectively. In vivo antibacterial activity showed that the MRSA burden in mice treated with DL(-)CSSNPs was reduced by almost 8-fold compared to those treated with pure vancomycin. (C) 2017 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.colsurfb.2017.07.049

文献信息

• ESTERS FROM SOLID POLYOLS AND UNSATURATED CARBOXYLIC ACIDS
  申请人：Daute Peter

  公开号：US20130035271A1

  公开（公告）日：2013-02-07

  The present invention relates to a process for the preparation of an ester from a polyol which is solid at 25° C. and a carboxylic acid component which contains at least 50 wt. % of at least one mono- or polyunsaturated aliphatic carboxylic acid, based on the total weight of the carboxylic acid component, in a reactor under reduced pressure. The invention also provides a device, a process for the preparation of a thermoplastic composition comprising the ester prepared according to the invention, a process for the production of a shaped article comprising the ester according to the invention or the thermoplastic composition according to the invention, a process for the production of a packed product, a process for the production of an at least partly coated object, and uses of the esters according to the invention as an additive in various compositions.

  本发明涉及一种在减压条件下，从在25℃下为固体的多元醇和至少含有50重量％的至少一种单元或多元不饱和脂肪族羧酸的羧酸组分中制备酯的方法。本发明还提供了一种装置、根据本发明制备的酯组成的热塑性组合物的制备方法、根据本发明制备的酯或热塑性组合物的成型制品的生产方法、包装产品的生产方法、至少部分涂覆物体的生产方法，以及将本发明的酯用作各种组合物中的添加剂的用途。
• ESTER PREPARATION WITH AFTER-TREATMENT
  申请人：Daute Peter

  公开号：US20130039872A1

  公开（公告）日：2013-02-14

  The present invention relates to a process for the preparation of an ester in a reactor, a device, a process for the preparation of a thermoplastic composition comprising the ester prepared according to the invention, a process for the production of a shaped article comprising the ester according to the invention or the thermoplastic composition according to the invention, a process for the production of a packed product, a process for the production of an at least partly coated object, and uses of the esters according to the invention as an additive in various compositions.

  本发明涉及一种在反应器中制备酯的过程、一种装置、一种制备包括根据本发明制备的酯的热塑性组合物的过程、一种制备包括根据本发明制备的酯或热塑性组合物的成型物的过程、一种制备包装产品的过程、一种制备至少部分涂覆的物体的过程，以及将本发明的酯用作各种组合物的添加剂的用途。
• Combinations of sunscreen agents with UV-A and UV-B filtering properties
  申请人：3V SIGMA S.p.A

  公开号：EP1027883A2

  公开（公告）日：2000-08-16

  Combinations of sunscreens comprising at least one specific anti UV-B filter with triazinoaniline structure and at least one specific anti UV-A filter selected from filters with benzoxazol substituted triazinoaniline structure and a long chain alkyl ester of a benzoxazolyl-aminophenyl-cyanoacrylic acid. Cosmetic and dermatological compositions containing them, optionally in combination with vitamins and/or other anti UV-A and anti UV-B filters.

  由至少一种特定的三嗪苯胺结构抗紫外线-B 过滤器和至少一种特定的抗紫外线-A 过滤器组成的组合防晒剂，后者选自苯并恶唑取代的三嗪苯胺结构过滤器和苯并恶唑-氨基苯基-氰基丙烯酸的长链烷基酯。含有这些成分的化妆品和皮肤科组合物，可选择与维生素和/或其他抗紫外线-A 和抗紫外线-B 过滤器结合使用。
• Combinations of sunscreens
  申请人：3V SIGMA S.p.A

  公开号：EP1300137A2

  公开（公告）日：2003-04-09

  Combinations of sunscreens comprising one or more anti UV-B filters and one or more anti UV-A filters and compositions containing them.

  由一种或多种抗 UV-B 紫外线过滤剂和一种或多种抗 UV-A 紫外线过滤剂组成的防晒剂组合，以及含有这些防晒剂的混合物。
• Method for obtaining O/W cosmetic emulsions with high water resistance
  申请人：3V SIGMA S.p.A

  公开号：EP1977789A1

  公开（公告）日：2008-10-08

  This invention relates to a method for obtaining cationic O/W emulsions designed for skin care, which present high water resistance associated with excellent "skin feeling" characteristics, consisting of incorporating a polymer obtainable by homopolymerisation of a monomer A or B or copolymerisation of A and B, wherein A and B are dialkylaminoalkyl acrylate or dialkylaminoalkyl methacrylate or their quaternary ammonium salts. The invention also concerns the compositions obtainable by the method.

  本发明涉及一种获得护肤用阳离子水包油型乳液的方法，该乳液具有高耐水性和优异的 "肤感 "特性，包括加入一种聚合物，该聚合物可通过单体 A 或 B 的均聚合或 A 和 B 的共聚合获得，其中 A 和 B 为丙烯酸二烷基氨基烷基酯或甲基丙烯酸二烷基氨基烷基酯或它们的季铵盐。本发明还涉及可通过该方法获得的组合物。