2-((4-硝基苯基)氨基)-2-苯基乙腈 | 88485-87-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-((4-硝基苯基)氨基)-2-苯基乙腈
• 英文名称: 2-((4-nitrophenyl)amino)-2-phenylacetonitrile
• 英文别名: α-Cyanobenzyl-p-nitroanilin；(4-nitro-anilino)-phenyl-acetonitrile；α-(4-Nitro-anilino)-phenylessigsaeure-nitril；N-(α-Cyan-benzyl)-4-nitro-anilin；2-(4-Nitroanilino)-2-phenylacetonitrile；2-(4-nitroanilino)-2-phenylacetonitrile
• CAS: 88485-87-4
• 化学式: C₁₄H₁₁N₃O₂
• 分子量: 253.26
• InChiKey: YVMMSGCGZILUIA-UHFFFAOYSA-N

物化性质

• 熔点：
  128-129 °C
• 沸点：
  452.4±40.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  81.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  扁桃腈 、 4-硝基苯胺 在 丙酮 作用下， 生成 2-((4-硝基苯基)氨基)-2-苯基乙腈
  参考文献：
  名称：

  LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE

  摘要：

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.

  DOI：

  10.1016/s0022-5347(05)67701-4

文献信息

• Efficient Three-Component Strecker Reaction of Acetals and Aromatic Amines Catalysed by Hafnium Tetrachloride at Room Temperature
  作者：Xue-Lin Zhang、Qin-Pei Wu、Qing-Shan Zhang

  DOI：10.3184/174751913x13814077309487

  日期：2013.11

  A straightforward, mild, efficient, one-pot method has been found for the synthesis of α-aminonitriles via three-component Strecker reaction using acetals or cyclic acetals, curious aromatic amines and trimethylsilyl cyanide (TMSCN) catalysed by hafnium tetrachloride at room temperature. It is with good to excellent yields under mild conditions. This developed approach has been successfully applied

  已经找到了一种简单、温和、高效的一锅法，通过三组分 Strecker 反应，使用缩醛或环状缩醛、奇怪的芳香胺和三甲基氰化硅烷 (TMSCN) 在室温下由四氯化铪催化合成 α-氨基腈。它在温和的条件下具有良好的收率。这种开发的方法已成功应用于合成具有多种官能团的各种α-氨基腈。
• Synthesis and characterization of an acidic nanostructure based on magnetic polyvinyl alcohol as an efficient heterogeneous nanocatalyst for the synthesis of α-aminonitriles
  作者：Ali Maleki、Jamal Rahimi、Zoleikha Hajizadeh、Maryam Niksefat

  DOI：10.1016/j.jorganchem.2018.12.002

  日期：2019.2

  the morphological, chemical and physical properties of the prepared nanocatalyst. All these results confirmed the successful synthesis of Fe3O4@PVA-SO3H. This heterogeneous nanocatalyst was then successfully used for the synthesis of α-aminonitrile derivatives by starting from an aldehyde, an aniline and trimethylsilyl cyanide (TMSCN). High efficiency, green chemistry properties, simple and easy separation

  本研究描述了一种基于聚乙烯醇（PVA）的新型磁性纳米复合材料的设计，制备和表征，该复合材料是无毒，水溶性，高机械稳定性和低成本的聚合物。傅里叶变换红外（FT-IR）光谱，场发射扫描电子显微镜（FE-SEM）图像，透射电子显微镜（TEM）图像，X射线衍射（XRD）模式，能量色散X射线（EDX）分析用热重（TG）分析法描述了所制备纳米催化剂的形貌，化学和物理性质。所有这些结果证实了Fe 3 O 4 @ PVA-SO 3的成功合成。H.这种多相纳米催化剂随后通过从醛，苯胺和三甲基甲硅烷基氰化物（TMSCN）开始成功地用于合成α-氨基腈衍生物。高效，绿色化学性质，简单容易的分离是这种纳米复合材料的特殊性质。Fe 3 O 4 @ PVA-SO 3 H可以通过外部磁体产生，可以重复使用十次，而不会改变其结构。
• Copper-vitamin B₆ coated on maghemite nanoparticles: A new convenient dual catalysis system to synthesize α-aminonitriles from benzyl alcohols
  作者：Naghmeh Esfandiary、Athar Nakisa、Iman Radfar、Kobra Azizi、Jamshid Azarnia Mehraban、Akbar Heydari

  DOI：10.1002/aoc.4589

  日期：2018.12

  A novel and effective dual catalysis system, copper combined with pyridoxal phosphate, which is anchored in maghemite nanoparticles were designed and applied to synthesize α‐aminonitriles from benzyl alcohols. This catalytic system has the potential ability to perform oxidation reactions and subsequently synthesize alpha‐amino nitrile in a reaction environment. Thus, the purpose of this paper is introducing

  设计了一种新颖有效的双催化体系，将铜与吡pyr醛磷酸盐结合并固定在磁赤铁矿纳米粒子中，并将其应用于由苄醇合成α-氨基腈。该催化系统具有执行氧化反应并随后在反应环境中合成α-氨基腈的潜在能力。因此，本文的目的是引入一种多相，可持续和可循环利用的催化体系，以进行需要连续过渡金属催化剂和有机催化剂才能实现目标分子的反应。
• Expeditious and efficient synthesis of Strecker’s α-aminonitriles catalyzed by sulfated polyborate
  作者：Krishna S. Indalkar、Chetan K. Khatri、Ganesh U. Chaturbhuj

  DOI：10.1016/j.tetlet.2017.04.058

  日期：2017.5

  A straightforward, mild, efficient, and environmentally benign protocol for a three-component Strecker reaction of aldehydes or ketones, amines, and trimethylsilyl cyanide catalyzed by sulfated polyborate has been described to afford α-aminonitriles under solvent-free reaction conditions. The major advantages of the present method are excellent yields, shorter reaction time, simple experimental procedure

  已经描述了一种简单，温和，有效和对环境有益的方案，用于在无溶剂反应条件下，由硫酸化多硼酸酯催化的醛或酮，胺和三甲基甲硅烷基氰化物的三组分Strecker反应。本方法的主要优点是优异的收率，较短的反应时间，简单的实验步骤，容易的后处理步骤，催化剂的可回收性，无溶剂的反应条件以及耐受各种官能团的能力，这带来了经济上和生态上的回报。 。
• Barnikow; Hagen; Hagen, Pharmazie, 1983, vol. 38, # 7, p. 449 - 452
  作者：Barnikow、Hagen、Hagen、Goeres、Richter、Fichtner

  DOI：——

  日期：——