2-(1-甲基-2-氧代环戊基)乙酸乙酯 | 58928-64-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-(1-甲基-2-氧代环戊基)乙酸乙酯
• 英文名称: 1-Methyl-2-oxocyclopentaneacetic acid ethyl ester
• 英文别名: 2-Methyl-2-(carbethoxymethyl)cyclopentanone；ethyl 2-(1-methyl-2-oxocyclopentyl)acetate；(1-methyl-2-oxo-cyclopentyl)-acetic acid ethyl ester；(1-Methyl-2-oxo-cyclopentyl)-essigsaeure-aethylester
• CAS: 58928-64-6
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.235
• InChiKey: QQGRKXOXTHCAOY-UHFFFAOYSA-N

物化性质

• 沸点：
  130-133 °C(Press: 14 Torr)
• 密度：
  1.036±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1-甲基-2-氧代环戊基)乙酸乙酯 以5%的产率得到
  参考文献：
  名称：

  ASSELIN A. A.; HUMBER L. G.; DOBSON T. A.; KOMLOSSY J.; MARTEL R. R., J. MED. CHEM. , 1976, 19, NO 6, 787-792

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基环戊酮 在 甲基锂 、 三乙胺 作用下， 反应 21.0h， 生成 2-(1-甲基-2-氧代环戊基)乙酸乙酯
  参考文献：
  名称：

  General method of synthesis of cyclopentanoid terpenic acids. Stereocontrolled total syntheses of (.+-.)-isocomenic acid and (.+-.)-epiisocomenic acid

  摘要：

  DOI：

  10.1021/jo00172a003

文献信息

• Cyclopentanoindoles, compositions containing such compounds and methods of treatment
  申请人：Merck Frosst Canada & Co.

  公开号：US06410583B1

  公开（公告）日：2002-06-25

  Substituted cyclopentanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.

  替代环戊基吲哚衍生物是前列腺素拮抗剂，因此对于治疗前列腺素介导的疾病非常有用。
• Carbazole acetic acid derivatives
  申请人：American Home Products Corporation

  公开号：US04057559A1

  公开（公告）日：1977-11-08

  Tetrahydrocyclopent[b]indole-3-acetic acid, tetrahydrocarbazole-1-acetic acid and hexahydrocyclohept[b]-indole-6-acetic acid derivatives in which the carbon bearing alkyl, lower alkenyl or lower cycloalkyl are disclosed. The compounds are useful antiinflammatory agents and methods for their preparation and use are described.

  四氢环戊[b]吲哚-3-乙酸、四氢咔唑-1-乙酸和六氢环庚[b]-吲哚-6-乙酸衍生物中披露了碳上带有烷基、低烯基或低环烷基。这些化合物是有用的抗炎药物，描述了它们的制备和使用方法。
• Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles
  作者：Andre A. Asselin、Leslie G. Humber、Thomas A. Dobson、Jacqueline Komlossy、Rene R. Martel

  DOI：10.1021/jm00228a010

  日期：1976.6

  A novel series of acidic cycloalkanoindoles comprising tetrahydrocarbazole-, cyclopentindole-, and cycloheptindole-1-acetic acids has been synthesized via the Fischer indolization between a phenylhydrazine and a 1-alkyl-2-oxocycloalkaneacetic acid ester. These compounds were evaluated, orally, for their capacities to decrease estabished adjuvant arthritis in rats. The most active compound of the series was 1-ethyl-8-n-propyl-1,2,3,4-tetrahydrocarbazole-1-acetic acid (AY-24 873),which had an ED50 of 1.1 +/- 0.2 mg/kg. AY-24 873 was also studied orally in rats for its effect on the acute inflammatory response in the carrageenin paw edema test. It was found that AY-24 873 was about ten times more active against the chromic than against the acute models of inflammation used.
• Chakravarty; Banerjee, Journal of the Indian Chemical Society, 1946, vol. 23, p. 377
  作者：Chakravarty、Banerjee

  DOI：——

  日期：——
• 79. Experiments on the synthesis of substances related to the sterols. Part XXXV. Furfurylideneacetone as a reagent for the extension of ring systems
  作者：L. E. King、Robert Robinson

  DOI：10.1039/jr9410000465

  日期：——