2-(2,4-二甲氧基苯甲酰基)苯甲酸 | 61959-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2,4-二甲氧基苯甲酰基)苯甲酸
• 英文名称: 2-[(2,4-dimethoxy)benzoyl]benzoic acid
• 英文别名: 2-(2,4-Dimethoxybenzoyl)-benzoesaeure；2-(2,4-dimethoxybenzoyl)benzoic acid；2-(2,4-dimethoxy-benzoyl)-benzoic acid；2-(2,4-Dimethoxy-benzoyl)-benzoesaeure；2'.4'-Dimethoxy-benzophenon-carbonsaeure-(2)；2-<2,4-Dimethoxy-benzoyl>-benzoesaeure
• CAS: 61959-31-7
• 化学式: C₁₆H₁₄O₅
• 分子量: 286.284
• InChiKey: DQVULWCHEVXNPM-UHFFFAOYSA-N

物化性质

• 熔点：
  164-165 °C
• 沸点：
  523.5±50.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2,4-二甲氧基苯甲酰基)苯甲酸 在 氢碘酸 作用下， 生成 2-(2-羟基-4-甲氧基苯甲酰基)苯甲酸
  参考文献：
  名称：

  Perkin; Robinson, Journal of the Chemical Society, 1908, vol. 93, p. 513

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Chlormethyl-2',4'-dimethoxy-benzophenon 在 氧气 、 sodium methylate 作用下， 以 二甲基亚砜 为溶剂， 生成 2-(2,4-二甲氧基苯甲酰基)苯甲酸
  参考文献：
  名称：

  苯酚的生物合成。第XX部分。通过邻取代二苯甲酮的碳负离子合成蒽醌

  摘要：

  在二甲亚砜中用甲醇钠处理2-氰基甲基-2'，4'-二甲氧基二苯甲酮，得到9-氰基-2-甲氧基蒽-10-醇，收率为95％。在温和的条件下，将其几乎定量地氧化为2-甲氧基蒽醌。蒽醌的这种合成与可能的生物合成途径的相关性已被讨论。2-氰基甲基-2'，4'-二甲氧基二苯甲酮与甲醇钠在甲醇中的相互作用得到3-甲氧基-1-（2,4-二甲氧基苯基）异喹啉。

  DOI：

  10.1039/j39690001873

文献信息

• Intrinsically thermochromic fluorans
  作者：Farid Azizian、Amanda J. Field、B. Mark Heron、Colin Kilner

  DOI：10.1039/c1cc15854f

  日期：——

  A Suzuki coupling strategy has been employed to access a series of novel fluorans substituted with a phenolic moiety. These fluorans display good thermochromism in methyl stearate and obviate the need for traditional complex formulations containing acidic colour developers.

  Suzuki偶联策略已用于获得一系列被酚部分取代的新型荧烷。这些荧烷在硬脂酸甲酯中显示出良好的热致变色性，从而消除了对含有酸性显色剂的传统复杂配方的需求。
• Lund, Journal of the Chemical Society, 1928, p. 1574
  作者：Lund

  DOI：——

  日期：——
• Synthesis and Structure−Activity Relationships of Sweet 2-Benzoylbenzoic Acid Derivatives
  作者：Anna Arnoldi、Angela Bassoli、Gigliola Borgonovo、Lucio Merlini、Gabriella Morini

  DOI：10.1021/jf960755i

  日期：1997.6.1

  Twenty-four analogues of the sweet compound 2-(4-methoxybenzoyl)benzoic acid 1 were synthesized and tasted. The structure-sweet taste relationships were studied by means of principal component analysis and by comparison with the existing sweet receptor models. Three possible glucophores were identified, which could correspond to the sites B, E1, and E2 of the Tinti-Nofre model. Some similarities between this class of compounds and isovanillic sweeteners were found.
• Unusual clinical manifestation of pheochromocytoma in a MEN2A patient
  作者：M. Guerrieri、S. Filipponi、G. Arnaldi、M. Giovagnetti、E. Lezoche、F. Mantero、A. Taccaliti

  DOI：10.1007/bf03343961

  日期：2002.1

  A case of unusual clinical manifestation of pheochromocytoma in a type 2A multiple endocrine neoplasia (MEN2A) patient is presented. A 27-year-old man affected by MEN2A syndrome; complaining of anxiety and depression, was admitted in our Division. Past medical history included a total thyroidectomy for medullary carcinoma in 1985, and left adrenalectomy for pheochromocytoma in 1994. Blood pressure was 130/85 mmHg without orthostatic hypotension and pulse rate was 72 beats/min. Laboratory data revealed thyroid hormones and carcinoembryonic antigen (CEA) in the normal range and high basal serum calcitonin levels (158 pg/ml). Plasma catecholamines and vanillymandelic acid resulted in normal levels but epinephrine/norepinephrine ratio was elevated (0.65). The glucagon stimulation test showed positive clinical and biochemical response. Magnetic resonance imaging (MRI) and meta-iodobenzylguanidine (MIBG) scintiscan confirmed the presence of bilateral adrenal masses. Bilateral adrenalectomy by laparoscopic anterior approach was performed. Histology was consistent with adrenal pheochromocytomas. After surgical approach, psychiatric findings disappeared and did not recur at follow-up in spite of no medication for two years. In conclusion, bilateral pheochromocytoma is more frequent in MEN2A syndrome and probably understimated if the follow-up is not prolonged. In these cases clinical features are often aspecific and basal hormonal data may be normal in a great number of patients. Therefore long-term observation is justified in these patients. Pheochromocytoma was described as the "great mimic" for the numerous subjective manifestations. Differential diagnosis among typical features of neuropsychiatric disorders and pheochromocytoma must be considered. (C) 2002, Editrice Kurtis.
• Jones; Perkin; Robinson, Journal of the Chemical Society, 1912, vol. 101, p. 260
  作者：Jones、Perkin、Robinson

  DOI：——

  日期：——