2-(2,6-二氟苯基)-1H-苯并咪唑-5-羧酸 | 333750-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-(2,6-二氟苯基)-1H-苯并咪唑-5-羧酸
• 中文别名: 2-(3-甲酰基-吲哚-1-基)-n-(四氢-呋喃-2-甲基)-乙酰胺
• 英文名称: 2-(3-formyl-indol-1-yl)-N-(tetrahydro-furan-2-ylmethyl)-acetamide
• 英文别名: 2-(3-formylindol-1-yl)-N-(oxolan-2-ylmethyl)acetamide
• CAS: 333750-65-5
• 化学式: C₁₆H₁₈N₂O₃
• mdl: MFCD02578945
• 分子量: 286.331
• InChiKey: MENDVZRTWVWJCK-UHFFFAOYSA-N

物化性质

• 沸点：
  567.8±30.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  60.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-吲哚酮 、 2-(2,6-二氟苯基)-1H-苯并咪唑-5-羧酸 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 2-[3-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-indol-1-yl]-N-(tetrahydro-furan-2-ylmethyl)-acetamide
  参考文献：
  名称：

  WO2006/105796

  摘要：

  公开号：

文献信息

• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• [EN] NOVEL INDOLINONE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'INDOLINONE
  申请人：LEO PHARMA AS

  公开号：WO2006105796A1

  公开（公告）日：2006-10-12

  [EN] The invention relates to novel indolinone derivatives of formula (I), wherein X, R1, R2, R3, R4, R5, Re, Ri', Ri , FV/ R4'/ FV and R6' are as shown herein, as well as their use in the treatment of inflammatory autoimmune diseases, in particular by administration via the oral route.
  [FR] La présente invention concerne de nouveaux dérivés d'indolinone de formule (I) où X, R1, R2, R3, R4, R5, Re, Ri', Ri, FV/ R4'/ FV et R6' sont tels que présentés dans la présente invention, ainsi que leur application au traitement de maladies inflammatoires auto-immunes, en particulier par administration par voie orale.
• [EN] BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES<br/>[FR] COMPLEXES BIFONCTIONNELS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE TELS COMPLEXES
  申请人：NUEVOLUTION AS

  公开号：WO2011127933A1

  公开（公告）日：2011-10-20

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.