2-[1-(2,6-Diphenoxypyrimidin-4-yl)-2,5-dimethylindol-3-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[1-(2,6-Diphenoxypyrimidin-4-yl)-2,5-dimethylindol-3-yl]acetic acid
• 化学式: C₂₈H₂₃N₃O₄
• 分子量: 465.5
• InChiKey: NSPGRIQEDQCXKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Use of indole-3-acetic acids in the treatment of asthma, copd and other diseases
  申请人：Baxter Andrew

  公开号：US20050101612A1

  公开（公告）日：2005-05-12

  The invention relates to N-substituted indole-3-acetic acid derivatives of the general formula in which R 1 is optionally substituted benzothiazolyl, pyrimidin-4-yl, imidazol-2-yl, oxazol-2-yl or thiazol-2-yl, R 2 is hydrogen, halogen, C 1-6 alkyl or C 1-6 alkoxy and R 3 is hydrogen or C 1-6 alkyl (see further details in the description), and their use in the treatment of respiratory diseases such as asthma, rhinitis and chronic obstructive pulmanory disease (COPD), and other diseases mediated by prostaglandin D2(PGD2).

  本发明涉及一般式N-取代吲哚-3-乙酸衍生物，其中R1是可选取代的苯并噻唑基、嘧啶-4-基、咪唑-2-基、噁唑-2-基或噻唑-2-基，R2是氢、卤素、C1-6烷基或C1-6烷氧基，R3是氢或C1-6烷基（在说明书中进一步细节见），以及它们在治疗呼吸道疾病如哮喘、鼻炎和慢性阻塞性肺疾病（COPD）以及其他由前列腺素D2（PGD2）介导的疾病中的应用。
• METHODS AND COMPOSITIONS FOR INHIBITING OR REDUCING HAIR LOSS
  申请人：The Trustees of the University of Pennsylvania

  公开号：EP3175856A1

  公开（公告）日：2017-06-07

  A non-therapeutic method of treating baldness in the scalp of a subject, the method comprising administering a prostaglandin D2 receptor (DP receptor) antagonist to the subject. The antagonist may be a prostaglandin D2 receptor 2 (DP2 receptor) antagonist.

  一种治疗受试者头皮秃发的非治疗方法，该方法包括向受试者施用前列腺素 D2 受体（DP 受体）拮抗剂。拮抗剂可以是前列腺素D2受体2（DP2受体）拮抗剂。
• Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10849841B2

  公开（公告）日：2020-12-01

  This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

  本发明提供了治疗雄激素性脱发(AGA)、痤疮、酒渣鼻、前列腺癌和良性前列腺肥大(BPH)的方法，包括使受试者与能降低前列腺素D2(PGD2)水平或活性、其下游信号传导或受体通路或前列腺素D2合成酶水平或活性的化合物或组合物接触的步骤；刺激毛发生长的方法，包括使受试者接触能提高或降低本发明靶基因活性或水平的化合物或组合物，或接触靶基因的蛋白产物或其类似物或模拟物；以及检测 AGA 和评估其治疗方法的方法，包括测量 PGD2 水平。
• USE OF INDOLE-3-ACETIC ACIDS IN THE TREATMENT OF ASTHMA, COPD AND OTHER DISEASES
  申请人：AstraZeneca AB

  公开号：EP1474137A1

  公开（公告）日：2004-11-10
• METHOD OF TREATING NEUROPATHIC PAIN USING A CRTH2 RECEPTOR ANTAGONIST
  申请人：Pfizer Limited

  公开号：EP1740179A1

  公开（公告）日：2007-01-10