2-(3,5-二氯苯基)-2-丙胺 | 129960-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3,5-二氯苯基)-2-丙胺
• 英文名称: N-[1-methyl-1-(3,5-dichlorophenyl)ethyl]amine
• 英文别名: 1-(3,5-Dichlorophenyl)-1-methylethylamine；1-methyl-1-(3,5-dichlorophenyl)ethylamine；3,5-dichloro-α,α-dimethylbenzylamine；2-(3,5-dichlorophenyl)propan-2-amine
• CAS: 129960-45-8
• 化学式: C₉H₁₁Cl₂N
• 分子量: 204.099
• InChiKey: AZEJGVWRTXUSHS-UHFFFAOYSA-N

物化性质

• 沸点：
  249.7±25.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2-(3,5-二氯苯基)-2-丙胺 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Synthesis of N-Substituted -Alkoxy-3-aryl-4-methyl-2,5-dihydro-2-pyrrolones

  摘要：

  DOI：

  10.1023/b:cohc.0000037310.26204.24
• 作为产物：
  描述：

  1,3-dichloro-5-isopropylbenzene 在 氨 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、1.33 kPa 条件下， 以80%的产率得到2-(3,5-二氯苯基)-2-丙胺
  参考文献：
  名称：

  3,5-二氯-α，α-二甲基苄胺合成工艺

  摘要：

  本发明属药物化学领域，涉及3,5‑二氯‑α，α‑二甲基苄胺合成工艺，具体步骤为：(1)以3,5‑二氯异丙基苯在光照的条件下卤代，生成3,5‑二氯‑α‑卤代异丙基苯；(2)3,5‑二氯‑α‑卤代异丙基苯在反应溶剂中与氨气反应生成3,5‑二氯‑α，α‑二甲基苄胺。本发明通过3,5‑二氯异丙基苯，在光照下溴化，然后再醇中胺解，即可得到3,5‑二氯‑α，α‑二甲基苄胺。其原料成本低，易操作，便于工业化生产。

  公开号：

  CN104529789B

文献信息

• SUBSTITUTED BIPIPERIDINYL DERIVATIVES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20160318866A1

  公开（公告）日：2016-11-03

  The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

  该发明涉及新型取代的双哌啶衍生物，涉及它们的制备方法，涉及它们用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防糖尿病微血管病变、四肢糖尿病溃疡，特别是促进糖尿病足溃疡愈合、糖尿病心力衰竭、糖尿病冠状微血管心脏疾病、外周和心脏血管疾病、血栓栓塞疾病和缺血、外周循环障碍、雷诺现象、CREST综合征、微循环障碍、间歇性跛行以及外周和自主神经病变的治疗和/或预防。
• NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20160221948A1

  公开（公告）日：2016-08-04

  The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R 1 represents optionally substituted C 1-4 alkyl, n shows integer of 1 to 4, R 2 represents optionally substituted C 1-4 alkyl or hydrogen atom, R 3 represents optionally substituted C 1-4 alkyl, R 4a , R 4b , R 4c , and R 4d , similarly or differently, represent optionally substituted C 6-14 aryl, optionally substituted C 1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C 6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

  本发明提供了一种由下式(I)表示的化合物或其药用可接受的盐： [其中，R1表示可选地取代的C1-4烷基，n表示1到4的整数，R2表示可选地取代的C1-4烷基或氢原子，R3表示可选地取代的C1-4烷基，R4a、R4b、R4c和R4d，相同或不同，表示可选地取代的C6-14芳基，可选地取代的C1-4烷基，或氢原子等，A表示可选地取代的C6-14芳基或可选地取代的5至11成员的杂芳基]。
• Substituted Arylimidazolone and Triazolone as Inhibitors of Vasopressin Receptors
  申请人：Meier Heinrich

  公开号：US20090312381A1

  公开（公告）日：2009-12-17

  The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

  本申请涉及新颖的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑酮，其生产方法，单独或组合使用以治疗和/或预防疾病，以及用于生产治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• N-substituted-aminomethyl cyclopropyl ketone derivatives or salts thereof and production process therefor
  申请人：——

  公开号：US20020156323A1

  公开（公告）日：2002-10-24

  Novel N-substituted-aminomethyl cyclopropyl ketone derivatives are represented by following Formula (1): 1 wherein R 1 , R 2 and R 3 are each a hydrogen atom or an aliphatic hydrocarbon group; and R 4 and R 5 are each a hydrogen atom or an arylmethyl group which may have a substituent, where at least one hydrogen atom or aryl group as a substituent is combined with a carbon atom in the methyl moiety of the arylmethyl group, and at least one of R 4 and R 5 is an arylmethyl group which may have a substituent. These compounds are useful for the preparation of aminomethyl cyclopropyl ketone derivatives and 2-amino-1-cyclopropylethanol derivatives or salts thereof.

  新型N-取代氨甲基环丙基酮衍生物由以下式（1）表示：其中R1、R2和R3分别是氢原子或脂肪烃基；R4和R5分别是氢原子或苄基基团，可能具有取代基，其中至少有一个氢原子或苄基作为取代基与苄基基团的甲基部分中的碳原子结合，且R4和R5中至少一个是可能具有取代基的苄基基团。这些化合物适用于制备氨甲基环丙基酮衍生物和2-氨基-1-环丙基乙醇衍生物或其盐。
• Pyrrolin-2-one compounds which are useful as herbicides
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：US05006157A1

  公开（公告）日：1991-04-09

  A cyclic amide compound of the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom, a lower alkyl group, a haloalkyl group, a lower alkoxy group, a haloalkoxy group, a lower alkylthio group or a nitro group; Y is a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, a phenyl group, an alkoxy group, a cycloalkoxy group, a cycloalkylalkoxy group, an alkenyloxy group, an alkynyloxy group, a benzyloxy group, a phenoxy group, a haloalkoxy group, a lower alkoxy-lower alkoxy group, a cyanoalkoxy group, an alkylthio group, an alkenylthio group, an alkynylthio group, a benzylthio group, a phenylthio group, ##STR2## (wherein W is an oxygen atom or a sulfur atom, R.sup.3 is a hydrogen atom or an alkyl group and R.sup.4 is an alkyl group), ##STR3## (wherein each of R.sup.5 and R.sup.6 is a hydrogen atom or a lower alkyl group, an alkylsulfonyl group, ##STR4## (wherein R.sup.5 and R.sup.6 are as defined above), an alkylcarbonyl group, an alkoxy carbonyl group, a hydroxy carbonyl group, a nitro group, a cyano group or a hydroxyl group; R is a hydrogen same or different is an alkyl group, or R.sup.1 and R.sup.2 together with the adjacent carbon atom form a ring; m is 0 or 1; n is an integer of from 1 to 5; and k is an integer of 1 or 2.

  该公式表示的环酰胺化合物：其中X是氢原子、卤原子、低碳基团、卤代碳基团、低碳氧基团、卤代氧基团、低碳硫基团或硝基基团；Y是氢原子、卤原子、烷基团、环烷基团、烯基团、炔基团、卤代烷基团、苯基、烷氧基、环烷氧基、环烷基氧基、烯氧基、炔氧基、苄氧基、苯氧基、卤代氧基、低碳氧基-低碳氧基、氰基氧基、烷硫基团、烯硫基团、炔硫基团、苄硫基团、苯硫基团；（其中W是氧原子或硫原子，R.sup.3是氢原子或烷基团，R.sup.4是烷基团），（其中R.sup.5和R.sup.6中的每一个是氢原子或低碳基团、烷基磺酰基、（其中R.sup.5和R.sup.6如上所定义），烷基羰基、烷氧羰基、羟基羰基、硝基、氰基或羟基；R是氢原子或烷基团，或R.sup.1和R.sup.2与相邻碳原子形成环；m为0或1；n为1至5的整数；k为1或2。