2-(3-吲哚基)乙基肼 | 21216-31-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-(3-吲哚基)乙基肼
• 中文别名: [2-(1H-吲哚-3-基)-乙基]-肼
• 英文名称: 3-(2-Hydrazinylethyl)-1H-indole
• 英文别名: 2-(1H-indol-3-yl)ethylhydrazine
• CAS: 21216-31-9
• 化学式: C₁₀H₁₃N₃
• mdl: MFCD07786368
• 分子量: 175.23
• InChiKey: IDDSMAGHZDFZBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  53.8
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

文献信息

• [EN] APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS<br/>[FR] INHIBITEURS DE KINASE 1 DE RÉGULATION DE SIGNAL D'APOPTOSE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009123986A1

  公开（公告）日：2009-10-08

  The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  本发明涉及具有以下结构的凋亡信号调节激酶1（"ASK1"）抑制化合物（I）；其中变量如本文所定义。该发明还涉及包含这些化合物的药物组合物、试剂盒和制造品；用于制备这些化合物的有用中间体和方法；以及使用这些化合物的方法。
• GLI1 INHIBITORS AND USES THEREOF
  申请人：Leadiant Biosciences SA

  公开号：EP3388419A1

  公开（公告）日：2018-10-17

  The present invention relates to compounds able to inhibit the protein Gli1 having the formula wherein the meanings of the substituents are indicated in the description, for use in the treatment of diseases related to Gli-1. The present invention also relates to compounds of formula (IIa) and (IIb) and to their use as medicaments, in particular for the treatment of diseases related to Gli1, more in particular for the treatment of tumors. Pharmaceutical compositions comprising said compounds of formula (IIa) or (IIb) are also within the scope of the present invention.

  本发明涉及一种能够抑制蛋白质Gli1的化合物，其具有下述式子，其中取代基的含义在说明中指明，用于治疗与Gli-1相关的疾病。本发明还涉及具有式子(IIa)和(IIb)的化合物及其作为药物的用途，特别用于治疗与Gli1相关的疾病，更具体地用于肿瘤的治疗。包含上述式子(IIa)或(IIb)的药物组合物也属于本发明的范围内。
• [EN] SHIKIMATE ANALOGUES AND METHODS OF USE<br/>[FR] ANALOGUES DE SHIKIMATE ET MÉTHODES D'UTILISATION
  申请人：UNIV OKLAHOMA

  公开号：WO2017142866A1

  公开（公告）日：2017-08-24

  The present disclosure, in at least certain embodiments, is directed to shikimate (shikimic acid) analogues and compositions thereof, kits which contain the shikimate analogues or compositions thereof, and methods of use of the compounds and compositions for treating epithelial surfaces before or following exposure to irritants, allergens, and toxic agents (for example, urushiol).

  本公开至少在某些实施例中涉及植酸（香草酸）类似物及其组成物，包含植酸类似物或其组成物的工具包，以及用于处理上皮表面在暴露于刺激物、过敏原和毒性剂（例如漆油）之前或之后的化合物和组成物的使用方法。
• [EN] POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS<br/>[FR] COMPOSÉS D'INDOLINE ET D'INDOLÉNINE POLYCYCLIQUES
  申请人：UNIV COLORADO REGENTS

  公开号：WO2016176634A1

  公开（公告）日：2016-11-03

  The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are capable of re-sensitizing the susceptibility of methicillin-resistant S. aureus to a β-lactam antibiotic. The present invention also relates to a method for producing and using the same.

  本发明涉及吲哚啉和吲哚啉生物碱化合物。具体来说，本发明的吲哚啉和吲哚啉生物碱化合物具有抗菌活性和/或能够使耐甲氧西林金黄色葡萄球菌重新对β-内酰胺类抗生素产生敏感性。本发明还涉及一种生产和使用该化合物的方法。
• Polycyclic indoline and indolenine compounds
  申请人：The Regents of the University of Colorado, a body corporate

  公开号：US10253024B2

  公开（公告）日：2019-04-09

  The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are capable of re-sensitizing the susceptibility of methicillin-resistant S. aureus to a β-lactam antibiotic. The present invention also relates to a method for producing and using the same.

  本发明涉及吲哚啉和吲哚烯生物碱化合物。特别是，本发明的吲哚啉和吲哚烯生物碱化合物具有抗菌活性和/或能够使耐甲氧西林金黄色葡萄球菌对β-内酰胺类抗生素的敏感性重新敏感。本发明还涉及生产和使用本发明的方法。