(N-(3-methylbut-2-enyl)-N-tosylamino) acetaldehyde | 1062368-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (N-(3-methylbut-2-enyl)-N-tosylamino) acetaldehyde
• 英文别名: 4-methyl-N-(3-methylbut-2-enyl)-N-(1-oxobutan-2-yl)benzenesulfonamide
• CAS: 1062368-83-5
• 化学式: C₁₆H₂₃NO₃S
• 分子量: 309.43
• InChiKey: AMFJTHGADGQFTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (N-(3-methylbut-2-enyl)-N-tosylamino) acetaldehyde 、 对氯苯胺 在 indium(III) chloride 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以94%的产率得到7-chloro-5,5-dimethyl-2-ethyl-3-tosylpyrrolo[3,4-b]quinoline
  参考文献：
  名称：

  Synthesis and antibacterial property of pyrrolopyrano quinolinones and pyrroloquinolines

  摘要：

  Synthesis of a series of novel pyrroloquinolinone and pyrroloquinoline derivatives has been accomplished by intramolecular domino Knoevenagel hetero Diels-Alder reaction and intramolecular imino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity against bacterial pathogens using disc diffusion and broth dilution methods. The efficacy of binding of these compounds to gyrase, an enzyme known to play a key role in bacterial replication is examined by studying its supercoiling and relaxation and also its gene expression using PCR method. The results indicated that most of the synthesised compounds exhibited good antibacterial activity against the microorganisms with MIC values of 5 mM and could inhibit gyrase effectively leading to cell death. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.02.060
• 作为产物：
  描述：

  对甲苯磺酰氯 在 四丁基溴化铵 、 potassium carbonate 、 sodium hydroxide 作用下， 以 二甲基亚砜 、 丙酮 、 苯 为溶剂， 反应 22.0h， 生成 (N-(3-methylbut-2-enyl)-N-tosylamino) acetaldehyde
  参考文献：
  名称：

  通过分子内亚氨基Diels-Alder反应的新型杂环三环组装：吡咯并[3,4- b ]喹啉的合成

  摘要：

  通过在短时间内以InCl 3为催化剂，衍生自芳族胺和N-异戊烯化脂肪醛的乙二胺在乙腈中以优异的产率合成了一系列六氢吡咯并[3,4- b ]喹啉。

  DOI：

  10.1016/j.tetlet.2008.11.092

文献信息

• An efficient synthesis of pyrano [4,5-c] pyrrole derivatives through microwave—accelerated intramolecular Knoevenagal hetero Diels–Alder reaction
  作者：Mathesan Jayagobi、Raghavachary Raghunathan

  DOI：10.1016/j.tetlet.2009.09.136

  日期：2009.12

  Synthesis of novel pyranopyrrole derivatives has been achieved by a one-pot IMHDA reaction of N-substituted aldehydes with various diones in the presence of ethylene diaminediacetate (EDDA) in excellent yields under mild conditions. (C) 2009 Elsevier Ltd. All rights reserved.