N-dimethylamino-carbonyl-N-methyl-carbamic acid chloride | 33345-40-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-dimethylamino-carbonyl-N-methyl-carbamic acid chloride
• 英文别名: 2,4,4-trimethylallophanoyl chloride；(chloroformyl)trimethylurea；trimethylallophanoyl chloride；Trimethylallophansaeurechlorid；2,4,4-Trimethylallophanyl chloride；N-(dimethylcarbamoyl)-N-methylcarbamoyl chloride
• CAS: 33345-40-3
• 化学式: C₅H₉ClN₂O₂
• 分子量: 164.592
• InChiKey: KARPAXFMDRDIJO-UHFFFAOYSA-N

物化性质

• 沸点：
  99.5-100 °C(Press: 1 Torr)
• 密度：
  1.254±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-dimethylamino-carbonyl-N-methyl-carbamic acid chloride 在 吡啶 、 4-二甲氨基吡啶 、 N-溴代丁二酰亚胺(NBS) 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 43.0h， 生成 N-(dimethylcarbamoyl)-N,N',N'-trimethylazodicarboxamide
  参考文献：
  名称：

  Photolysis of dimethylcarbamoyl azide in the presence of a cyclic aminimide

  摘要：

  DOI：

  10.1021/jo00370a020
• 作为产物：
  描述：

  trimethyl(trimethylsilyl)urea 以78%的产率得到
  参考文献：
  名称：

  MIRONOV, V. F.;KOZYUKOV, V. P.;ORLOV, G. I., ZH. OBSHCH. XIMII, 1982, 52, N 9, 2102-2106

  摘要：

  DOI：

文献信息

• Allophanoylpiperazine compound and analgesic composition containing same
  申请人：Taiho Pharmaceutical Company Limited

  公开号：US04666911A1

  公开（公告）日：1987-05-19

  An analgesic compositon containing as active ingredient an allophanoylpiperazine compound represented by the general formula ##STR1## wherein R.sup.1 represents a lower alkyl group or phenyl group; R.sup.2 and R.sup.3 each represents a hydrogen atom or a lower alkyl group; and R.sup.4 represents a phenyl group or a substituted phenyl group having as substituent a halogen atom or methyl, trifluoromethyl, hydroxyl, methoxy, methylenedioxy, nitro, or carboxyl group; pyridyl group, pyrimidyl group, thiazolyl group, benzyl group, cinnamyl group, cyclohexyl group, a lower alkyl group, a substituted lower alkyl group having chlorine atom or hydroxyl group as substituent; or a lower alkenyl group.

  一种镇痛组合物，其活性成分为由通式##STR1##所表示的异脲酰哌嗪化合物，其中R.sup.1代表较低的烷基或苯基；R.sup.2和R.sup.3各自代表氢原子或较低的烷基；R.sup.4代表苯基或取代苯基，其取代基为卤原子或甲基、三氟甲基、羟基、甲氧基、亚甲二氧基、硝基或羧基；吡啶基、嘧啶基、噻唑基、苄基、肉桂基、环己基、较低的烷基、取代的较低的烷基，其取代基为氯原子或羟基；或较低的烯基。
• DIDEPSIPEPTIDE-BASED ENDOPARASITICIDES, NEW DIDEPSIPEPTIDES AND PROCESS FOR PREPARING THE SAME
  申请人：——

  公开号：US20020142969A1

  公开（公告）日：2002-10-03

  The present invention relates to the use of didepsipepides of the general formula (I) and their salts 1 in which the radicals have the meaning given in the description, and to new didepsidpeptides and processes for their preparation.

  本发明涉及使用一般式(I)的二脱氨肽和其盐，其中基团的含义如描述所示，并涉及新的二脱氨肽和其制备方法。
• Novel 1,1,3,5-substituted biuret compound and a pharmaceutical
  申请人：Taiho Pharmaceutical Company Limited

  公开号：US04293713A1

  公开（公告）日：1981-10-06

  A novel 1,1,3,5-substituted biuret compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are respectively the same or different, and each are alkyl groups having 1 to 4 carbon atoms; R.sup.3 is a cyclohexyl group or a phenyl group which may be unsubstituted or may have at least one substituent selected from the group consisting of chlorine, bromine, fluorine, methyl, trifluoromethyl, dimethylamino, methoxy, methylthio, nitro and acetyl. The novel 1,1,3,5-substituted biuret compounds are useful as an analgesic, anti-inflammatory and/or anti-pyretic agent.

  一种新型的1,1,3,5-取代的双脲化合物，其化学式为：##STR1## 其中，R1和R2分别相同或不同，且均为1至4个碳原子的烷基基团；R3为环己基基团或苯基基团，可以未取代或取代至少一种来自氯、溴、氟、甲基、三氟甲基、二甲氨基、甲氧基、甲硫基、硝基和乙酰基的取代基。该新型的1,1,3,5-取代的双脲化合物可用作镇痛剂、抗炎剂和/或退热剂。
• Pharmaceutical composition and methods of use containing
  申请人：Taiho Pharmaceutical Company, Limited

  公开号：US04278672A1

  公开（公告）日：1981-07-14

  An analgesic, anti-inflammatory or anti-pyretic composition containing 1,1,3,5-substituted biuret compound of the formula, ##STR1## wherein R.sup.1 is a lower alkyl group or a phenyl group; R.sup.2 is a lower alkyl group, a phenyl group or a substituted phenyl group having chlorine atom(s), methyl group(s) or methoxy group(s) as the substituent(s), further R.sup.1 and R.sup.2 may form a single ring containing one or two hetero atoms including the adjacent nitrogen atom; R.sup.3 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.4 is a phenyl group, a substituted phenyl group having halogen atom(s), trifluoromethyl group(s), methyl group(s), methoxy group(s), dimethylamino group(s), nitro group(s), hydroxyl group(s), acetyl group(s) or methylthio group(s) as the substituent(s), a benzyl group, a cyclohexyl group or a lower alkyl group, as the active ingredient.

  一种止痛、抗炎或退热组合物，包含式为##STR1##的1,1,3,5-取代双脲化合物，其中R.sup.1是较低的烷基或苯基；R.sup.2是较低的烷基、苯基或取代苯基，其取代基包括氯原子、甲基基团或甲氧基团，此外R.sup.1和R.sup.2可以形成一个单环，其中包含一个或两个杂原子，包括相邻的氮原子；R.sup.3是氢原子、较低的烷基或苯基；R.sup.4是苯基、取代苯基，其取代基包括卤原子、三氟甲基基团、甲基基团、甲氧基团、二甲基氨基团、硝基团、羟基团、乙酰基团或甲硫基团，苄基、环己基或较低的烷基，作为活性成分。
• Didepsipeptide-based endoparasiticides, new didepsipeptides and process for preparing the same
  申请人：——

  公开号：US20040034048A1

  公开（公告）日：2004-02-19

  The present invention relates to the use of didepsipeptides of the general formula (I) and their salts 1 in which the radicals have the meaning given in the description, and to new didepsidpeptides and processes for their preparation.

  本发明涉及使用通式（I）的二肽酯及其盐，其中基团的含义如描述中所述，以及新的二肽酯和其制备方法。