溴乙酰基肉碱 | 10034-25-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 溴乙酰基肉碱
• 英文名称: Carnitine bromoacetate
• 英文别名: 3-(2-bromoacetyl)oxy-4-(trimethylazaniumyl)butanoate
• CAS: 10034-25-0
• 化学式: C9H16BrNO4
• 分子量: 282.13
• InChiKey: XSPKQMNUNNSJIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Beta-Hydroxy-Gamma-Aminophosphonates and Methods for the Preparation and Use Thereof
  申请人：De La Cruz Cordero Ricardo Abraham

  公开号：US20100087400A1

  公开（公告）日：2010-04-08

  The present invention provides β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treatment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.

  本发明提供了抑制肉碱酰转移酶的β-羟基-γ-氨基膦酸酯、β-氨基-γ-氨基膦酸酯及其类似物。本发明还提供包含这些β-羟基-γ-氨基膦酸酯、β-氨基-γ-氨基膦酸酯及其类似物的组合物，以及使用这些化合物和组合物在治疗、缓解或预防与脂肪酸代谢有关的病理条件、疾病或障碍，如非胰岛素依赖型糖尿病或肥胖症的方法。本发明还提供制备这些化合物和组合物的方法。
• AMINOCARNITINES
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP0177574A1

  公开（公告）日：1986-04-16
• EP0177574A4
  申请人：——

  公开号：EP0177574A4

  公开（公告）日：1987-08-03
• METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP1212056B1

  公开（公告）日：2005-12-07
• BETA-HYDROXY-GAMMA-AMINOPHOSPHONATES AND METHODS FOR THE PREPARATION AND USE THEREOF
  申请人：Nucitec S.A. de C.V.

  公开号：EP2348865B1

  公开（公告）日：2015-07-15